In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242011000600008 |
Resumo: | Squamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 µg/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata. |
id |
SBPQO-1_82414b2cc3068a4bfe26a38e7ff904b7 |
---|---|
oai_identifier_str |
oai:scielo:S1806-83242011000600008 |
network_acronym_str |
SBPQO-1 |
network_name_str |
Brazilian Oral Research |
repository_id_str |
|
spelling |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavityMouth NeoplasmCarcinoma, Squamous CellPlant ExtractsSquamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 µg/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242011000600008Brazilian Oral Research v.25 n.6 2011reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/S1806-83242011000600008info:eu-repo/semantics/openAccessOzi,Joana MattosSuffredini,Ivana BarbosaPaciencia,MateusFrana,Sergio AlexandreDib,Luciano Lauriaeng2011-12-13T00:00:00Zoai:scielo:S1806-83242011000600008Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2011-12-13T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity |
title |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity |
spellingShingle |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity Ozi,Joana Mattos Mouth Neoplasm Carcinoma, Squamous Cell Plant Extracts |
title_short |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity |
title_full |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity |
title_fullStr |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity |
title_full_unstemmed |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity |
title_sort |
In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity |
author |
Ozi,Joana Mattos |
author_facet |
Ozi,Joana Mattos Suffredini,Ivana Barbosa Paciencia,Mateus Frana,Sergio Alexandre Dib,Luciano Lauria |
author_role |
author |
author2 |
Suffredini,Ivana Barbosa Paciencia,Mateus Frana,Sergio Alexandre Dib,Luciano Lauria |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ozi,Joana Mattos Suffredini,Ivana Barbosa Paciencia,Mateus Frana,Sergio Alexandre Dib,Luciano Lauria |
dc.subject.por.fl_str_mv |
Mouth Neoplasm Carcinoma, Squamous Cell Plant Extracts |
topic |
Mouth Neoplasm Carcinoma, Squamous Cell Plant Extracts |
description |
Squamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 µg/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242011000600008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242011000600008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1806-83242011000600008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.25 n.6 2011 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318322504695808 |