Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal: STÄHELIN,Heron
Data de Publicação: 2021
Outros Autores: FRANCISCO,Ana Lucia Noronha, MARIANO,Fernanda Viviane, KOWALSKI,Luiz Paulo, GONDAK,Rogério
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Oral Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276
Resumo: Abstract Smoking has been shown to alter innate and adaptive immune responses and is directly associated with the onset of oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the effect of cigarette smoke exposure on dendritic cells (DCs) from OSCC patients. CD1a and CD83 antibodies were used to identify immature and mature DCs, respectively, by immunohistochemistry in OSCC samples of 24 smokers and 24 non-smokers. Density of DCs was calculated in intra and peritumoral areas. Clinical and microscopic findings were reviewed and analyzed for all patients. Smokers with OSCC had a lower density of intra and peritumoral DCs when compared to non-smokers. Tumors classified as moderately/poorly differentiated had lower peritumoral CD1a+ DCs than well-differentiated tumors (p < 0.001). Smoking contributed to a depletion of immature and mature DCs in the OSCC.
id SBPQO-1_906263882238c38309ab6140fc3064ae
oai_identifier_str oai:scielo:S1806-83242021000100276
network_acronym_str SBPQO-1
network_name_str Brazilian Oral Research
repository_id_str
spelling Impact of smoking on dendritic cells in patients with oral squamous cell carcinomaMouth NeoplasmsImmunityCigarette SmokingAbstract Smoking has been shown to alter innate and adaptive immune responses and is directly associated with the onset of oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the effect of cigarette smoke exposure on dendritic cells (DCs) from OSCC patients. CD1a and CD83 antibodies were used to identify immature and mature DCs, respectively, by immunohistochemistry in OSCC samples of 24 smokers and 24 non-smokers. Density of DCs was calculated in intra and peritumoral areas. Clinical and microscopic findings were reviewed and analyzed for all patients. Smokers with OSCC had a lower density of intra and peritumoral DCs when compared to non-smokers. Tumors classified as moderately/poorly differentiated had lower peritumoral CD1a+ DCs than well-differentiated tumors (p < 0.001). Smoking contributed to a depletion of immature and mature DCs in the OSCC.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276Brazilian Oral Research v.35 2021reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2021.vol35.0075info:eu-repo/semantics/openAccessSTÄHELIN,HeronFRANCISCO,Ana Lucia NoronhaMARIANO,Fernanda VivianeKOWALSKI,Luiz PauloGONDAK,Rogérioeng2021-08-31T00:00:00Zoai:scielo:S1806-83242021000100276Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2021-08-31T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false
dc.title.none.fl_str_mv Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
title Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
spellingShingle Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
STÄHELIN,Heron
Mouth Neoplasms
Immunity
Cigarette Smoking
title_short Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
title_full Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
title_fullStr Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
title_full_unstemmed Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
title_sort Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
author STÄHELIN,Heron
author_facet STÄHELIN,Heron
FRANCISCO,Ana Lucia Noronha
MARIANO,Fernanda Viviane
KOWALSKI,Luiz Paulo
GONDAK,Rogério
author_role author
author2 FRANCISCO,Ana Lucia Noronha
MARIANO,Fernanda Viviane
KOWALSKI,Luiz Paulo
GONDAK,Rogério
author2_role author
author
author
author
dc.contributor.author.fl_str_mv STÄHELIN,Heron
FRANCISCO,Ana Lucia Noronha
MARIANO,Fernanda Viviane
KOWALSKI,Luiz Paulo
GONDAK,Rogério
dc.subject.por.fl_str_mv Mouth Neoplasms
Immunity
Cigarette Smoking
topic Mouth Neoplasms
Immunity
Cigarette Smoking
description Abstract Smoking has been shown to alter innate and adaptive immune responses and is directly associated with the onset of oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the effect of cigarette smoke exposure on dendritic cells (DCs) from OSCC patients. CD1a and CD83 antibodies were used to identify immature and mature DCs, respectively, by immunohistochemistry in OSCC samples of 24 smokers and 24 non-smokers. Density of DCs was calculated in intra and peritumoral areas. Clinical and microscopic findings were reviewed and analyzed for all patients. Smokers with OSCC had a lower density of intra and peritumoral DCs when compared to non-smokers. Tumors classified as moderately/poorly differentiated had lower peritumoral CD1a+ DCs than well-differentiated tumors (p < 0.001). Smoking contributed to a depletion of immature and mature DCs in the OSCC.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1807-3107bor-2021.vol35.0075
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
publisher.none.fl_str_mv Sociedade Brasileira de Pesquisa Odontológica - SBPqO
dc.source.none.fl_str_mv Brazilian Oral Research v.35 2021
reponame:Brazilian Oral Research
instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron:SBPQO
instname_str Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
instacron_str SBPQO
institution SBPQO
reponame_str Brazilian Oral Research
collection Brazilian Oral Research
repository.name.fl_str_mv Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
repository.mail.fl_str_mv pob@edu.usp.br||bor@sbpqo.org.br
_version_ 1750318327671029760