Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276 |
Resumo: | Abstract Smoking has been shown to alter innate and adaptive immune responses and is directly associated with the onset of oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the effect of cigarette smoke exposure on dendritic cells (DCs) from OSCC patients. CD1a and CD83 antibodies were used to identify immature and mature DCs, respectively, by immunohistochemistry in OSCC samples of 24 smokers and 24 non-smokers. Density of DCs was calculated in intra and peritumoral areas. Clinical and microscopic findings were reviewed and analyzed for all patients. Smokers with OSCC had a lower density of intra and peritumoral DCs when compared to non-smokers. Tumors classified as moderately/poorly differentiated had lower peritumoral CD1a+ DCs than well-differentiated tumors (p < 0.001). Smoking contributed to a depletion of immature and mature DCs in the OSCC. |
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Impact of smoking on dendritic cells in patients with oral squamous cell carcinomaMouth NeoplasmsImmunityCigarette SmokingAbstract Smoking has been shown to alter innate and adaptive immune responses and is directly associated with the onset of oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the effect of cigarette smoke exposure on dendritic cells (DCs) from OSCC patients. CD1a and CD83 antibodies were used to identify immature and mature DCs, respectively, by immunohistochemistry in OSCC samples of 24 smokers and 24 non-smokers. Density of DCs was calculated in intra and peritumoral areas. Clinical and microscopic findings were reviewed and analyzed for all patients. Smokers with OSCC had a lower density of intra and peritumoral DCs when compared to non-smokers. Tumors classified as moderately/poorly differentiated had lower peritumoral CD1a+ DCs than well-differentiated tumors (p < 0.001). Smoking contributed to a depletion of immature and mature DCs in the OSCC.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276Brazilian Oral Research v.35 2021reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2021.vol35.0075info:eu-repo/semantics/openAccessSTÄHELIN,HeronFRANCISCO,Ana Lucia NoronhaMARIANO,Fernanda VivianeKOWALSKI,Luiz PauloGONDAK,Rogérioeng2021-08-31T00:00:00Zoai:scielo:S1806-83242021000100276Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2021-08-31T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma |
title |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma |
spellingShingle |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma STÄHELIN,Heron Mouth Neoplasms Immunity Cigarette Smoking |
title_short |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma |
title_full |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma |
title_fullStr |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma |
title_full_unstemmed |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma |
title_sort |
Impact of smoking on dendritic cells in patients with oral squamous cell carcinoma |
author |
STÄHELIN,Heron |
author_facet |
STÄHELIN,Heron FRANCISCO,Ana Lucia Noronha MARIANO,Fernanda Viviane KOWALSKI,Luiz Paulo GONDAK,Rogério |
author_role |
author |
author2 |
FRANCISCO,Ana Lucia Noronha MARIANO,Fernanda Viviane KOWALSKI,Luiz Paulo GONDAK,Rogério |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
STÄHELIN,Heron FRANCISCO,Ana Lucia Noronha MARIANO,Fernanda Viviane KOWALSKI,Luiz Paulo GONDAK,Rogério |
dc.subject.por.fl_str_mv |
Mouth Neoplasms Immunity Cigarette Smoking |
topic |
Mouth Neoplasms Immunity Cigarette Smoking |
description |
Abstract Smoking has been shown to alter innate and adaptive immune responses and is directly associated with the onset of oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the effect of cigarette smoke exposure on dendritic cells (DCs) from OSCC patients. CD1a and CD83 antibodies were used to identify immature and mature DCs, respectively, by immunohistochemistry in OSCC samples of 24 smokers and 24 non-smokers. Density of DCs was calculated in intra and peritumoral areas. Clinical and microscopic findings were reviewed and analyzed for all patients. Smokers with OSCC had a lower density of intra and peritumoral DCs when compared to non-smokers. Tumors classified as moderately/poorly differentiated had lower peritumoral CD1a+ DCs than well-differentiated tumors (p < 0.001). Smoking contributed to a depletion of immature and mature DCs in the OSCC. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100276 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2021.vol35.0075 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.35 2021 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318327671029760 |