Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity

Detalhes bibliográficos
Autor(a) principal: Pereira-da-Silva, Tiago
Data de Publicação: 2021
Outros Autores: Napoleão, Patricia, Costa, Marina C., Gabriel, André F., Selas, Mafalda, Silva, Filipa, Enguita, Francisco J., Ferreira, Rui Cruz, Carmo, Miguel Mota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46989
Resumo: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
id RCAP_e67f98a7cbe6d04c651a9c7974a07936
oai_identifier_str oai:repositorio.ul.pt:10451/46989
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicityAtherosclerosisCigarette smokingmiR-27bPeripheral artery diseaseCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Cigarette smoking is a risk factor for the development of peripheral artery disease (PAD), although the proatherosclerotic mediators of cigarette smoking are not entirely known. We explored whether circulating microRNAs (miRNAs) are dysregulated in cigarette smokers and associated with the presence of PAD. Ninety-four participants were recruited, including 58 individuals without and 36 with PAD, 51 never smokers, 28 prior smokers, and 15 active smokers. The relative expression of six circulating miRNAs with distinct biological roles (miR-21, miR-27b, miR-29a, miR-126, miR-146, and miR-218) was assessed. Cigarette smoking was associated with the presence of PAD in multivariate analysis. Active smokers, but not prior smokers, presented miR-27b downregulation and higher leukocyte, neutrophil, and lymphocyte counts; miR-27b expression levels were independently associated with active smoking. Considering the metabolic and/or inflammatory abnormalities induced by cigarette smoking, miR-27b was independently associated with the presence of PAD and downregulated in patients with more extensive PAD. In conclusion, the atheroprotective miR-27b was downregulated in active smokers, but not in prior smokers, and miR-27b expression was independently associated with the presence of PAD. These unreported data suggest that the proatherogenic properties of cigarette smoking are mediated by a downregulation of miR-27b, which may be attenuated by smoking cessation.MDPIRepositório da Universidade de LisboaPereira-da-Silva, TiagoNapoleão, PatriciaCosta, Marina C.Gabriel, André F.Selas, MafaldaSilva, FilipaEnguita, Francisco J.Ferreira, Rui CruzCarmo, Miguel Mota2021-03-23T13:55:01Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46989engJ Clin Med. 2021 Feb 22;10(4):89010.3390/jcm100408902077-0383info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:34Zoai:repositorio.ul.pt:10451/46989Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:05.125922Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
title Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
spellingShingle Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
Pereira-da-Silva, Tiago
Atherosclerosis
Cigarette smoking
miR-27b
Peripheral artery disease
title_short Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
title_full Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
title_fullStr Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
title_full_unstemmed Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
title_sort Cigarette smoking, miR-27b downregulation, and peripheral artery disease : insights into the mechanisms of smoking toxicity
author Pereira-da-Silva, Tiago
author_facet Pereira-da-Silva, Tiago
Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Ferreira, Rui Cruz
Carmo, Miguel Mota
author_role author
author2 Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Ferreira, Rui Cruz
Carmo, Miguel Mota
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Pereira-da-Silva, Tiago
Napoleão, Patricia
Costa, Marina C.
Gabriel, André F.
Selas, Mafalda
Silva, Filipa
Enguita, Francisco J.
Ferreira, Rui Cruz
Carmo, Miguel Mota
dc.subject.por.fl_str_mv Atherosclerosis
Cigarette smoking
miR-27b
Peripheral artery disease
topic Atherosclerosis
Cigarette smoking
miR-27b
Peripheral artery disease
description Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-03-23T13:55:01Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46989
url http://hdl.handle.net/10451/46989
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Med. 2021 Feb 22;10(4):890
10.3390/jcm10040890
2077-0383
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134536476393472

Registros relacionados