Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts

Detalhes bibliográficos
Autor(a) principal: Silva,Denise Rossato
Data de Publicação: 2022
Outros Autores: Freitas,Alana Ambos, Guimarães,Amanda Reis, D’Ambrosio,Lia, Centis,Rosella, Muñoz-Torrico,Marcela, Visca,Dina, Migliori,Giovanni Battista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Pneumologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000200205
Resumo: ABSTRACT Objective: To evaluate lung function in a cohort of patients with a history of pulmonary tuberculosis in Brazil, as well as to evaluate the decline in lung function over time and compare it with that observed in similar cohorts in Mexico and Italy. Methods: The three cohorts were compared in terms of age, smoking status, pulmonary function test results, six-minute walk test results, and arterial blood gas results. In the Brazilian cohort, pulmonary function test results, six-minute walk test results, and arterial blood gas results right after the end of tuberculosis treatment were compared with those obtained at the end of the follow-up period. Results: The three cohorts were very different regarding pulmonary function test results. The most common ventilatory patterns in the Brazilian, Italian, and Mexican cohorts were an obstructive pattern, a mixed pattern, and a normal pattern (in 58 patients [50.9%], in 18 patients [41.9%], and in 26 patients [44.1%], respectively). Only 2 multidrug-resistant tuberculosis cases were included in the Brazilian cohort, whereas, in the Mexican cohort, 27 cases were included (45.8%). Mean PaO2 and mean SaO2 were lower in the Mexican cohort than in the Brazilian cohort (p < 0.0001 and p < 0.002 for PaO2 and SaO2, respectively). In the Brazilian cohort, almost all functional parameters deteriorated over time. Conclusions: This study reinforces the importance of early and effective treatment of drug-susceptible tuberculosis patients, because multidrug-resistant tuberculosis increases lung damage. When patients complete their tuberculosis treatment, they should be evaluated as early as possible, and, if post-tuberculosis lung disease is diagnosed, they should be managed and offered pulmonary rehabilitation because there is evidence that it is effective in these patients.
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spelling Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohortsTuberculosisTuberculosis, multidrug-resistantSpirometryRehabilitationABSTRACT Objective: To evaluate lung function in a cohort of patients with a history of pulmonary tuberculosis in Brazil, as well as to evaluate the decline in lung function over time and compare it with that observed in similar cohorts in Mexico and Italy. Methods: The three cohorts were compared in terms of age, smoking status, pulmonary function test results, six-minute walk test results, and arterial blood gas results. In the Brazilian cohort, pulmonary function test results, six-minute walk test results, and arterial blood gas results right after the end of tuberculosis treatment were compared with those obtained at the end of the follow-up period. Results: The three cohorts were very different regarding pulmonary function test results. The most common ventilatory patterns in the Brazilian, Italian, and Mexican cohorts were an obstructive pattern, a mixed pattern, and a normal pattern (in 58 patients [50.9%], in 18 patients [41.9%], and in 26 patients [44.1%], respectively). Only 2 multidrug-resistant tuberculosis cases were included in the Brazilian cohort, whereas, in the Mexican cohort, 27 cases were included (45.8%). Mean PaO2 and mean SaO2 were lower in the Mexican cohort than in the Brazilian cohort (p < 0.0001 and p < 0.002 for PaO2 and SaO2, respectively). In the Brazilian cohort, almost all functional parameters deteriorated over time. Conclusions: This study reinforces the importance of early and effective treatment of drug-susceptible tuberculosis patients, because multidrug-resistant tuberculosis increases lung damage. When patients complete their tuberculosis treatment, they should be evaluated as early as possible, and, if post-tuberculosis lung disease is diagnosed, they should be managed and offered pulmonary rehabilitation because there is evidence that it is effective in these patients.Sociedade Brasileira de Pneumologia e Tisiologia2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000200205Jornal Brasileiro de Pneumologia v.48 n.2 2022reponame:Jornal Brasileiro de Pneumologia (Online)instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)instacron:SBPT10.36416/1806-3756/e20210515info:eu-repo/semantics/openAccessSilva,Denise RossatoFreitas,Alana AmbosGuimarães,Amanda ReisD’Ambrosio,LiaCentis,RosellaMuñoz-Torrico,MarcelaVisca,DinaMigliori,Giovanni Battistaeng2022-05-10T00:00:00Zoai:scielo:S1806-37132022000200205Revistahttp://www.jornaldepneumologia.com.br/default.aspONGhttps://old.scielo.br/oai/scielo-oai.php||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br1806-37561806-3713opendoar:2022-05-10T00:00Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)false
dc.title.none.fl_str_mv Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
title Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
spellingShingle Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
Silva,Denise Rossato
Tuberculosis
Tuberculosis, multidrug-resistant
Spirometry
Rehabilitation
title_short Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
title_full Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
title_fullStr Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
title_full_unstemmed Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
title_sort Post-tuberculosis lung disease: a comparison of Brazilian, Italian, and Mexican cohorts
author Silva,Denise Rossato
author_facet Silva,Denise Rossato
Freitas,Alana Ambos
Guimarães,Amanda Reis
D’Ambrosio,Lia
Centis,Rosella
Muñoz-Torrico,Marcela
Visca,Dina
Migliori,Giovanni Battista
author_role author
author2 Freitas,Alana Ambos
Guimarães,Amanda Reis
D’Ambrosio,Lia
Centis,Rosella
Muñoz-Torrico,Marcela
Visca,Dina
Migliori,Giovanni Battista
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Denise Rossato
Freitas,Alana Ambos
Guimarães,Amanda Reis
D’Ambrosio,Lia
Centis,Rosella
Muñoz-Torrico,Marcela
Visca,Dina
Migliori,Giovanni Battista
dc.subject.por.fl_str_mv Tuberculosis
Tuberculosis, multidrug-resistant
Spirometry
Rehabilitation
topic Tuberculosis
Tuberculosis, multidrug-resistant
Spirometry
Rehabilitation
description ABSTRACT Objective: To evaluate lung function in a cohort of patients with a history of pulmonary tuberculosis in Brazil, as well as to evaluate the decline in lung function over time and compare it with that observed in similar cohorts in Mexico and Italy. Methods: The three cohorts were compared in terms of age, smoking status, pulmonary function test results, six-minute walk test results, and arterial blood gas results. In the Brazilian cohort, pulmonary function test results, six-minute walk test results, and arterial blood gas results right after the end of tuberculosis treatment were compared with those obtained at the end of the follow-up period. Results: The three cohorts were very different regarding pulmonary function test results. The most common ventilatory patterns in the Brazilian, Italian, and Mexican cohorts were an obstructive pattern, a mixed pattern, and a normal pattern (in 58 patients [50.9%], in 18 patients [41.9%], and in 26 patients [44.1%], respectively). Only 2 multidrug-resistant tuberculosis cases were included in the Brazilian cohort, whereas, in the Mexican cohort, 27 cases were included (45.8%). Mean PaO2 and mean SaO2 were lower in the Mexican cohort than in the Brazilian cohort (p < 0.0001 and p < 0.002 for PaO2 and SaO2, respectively). In the Brazilian cohort, almost all functional parameters deteriorated over time. Conclusions: This study reinforces the importance of early and effective treatment of drug-susceptible tuberculosis patients, because multidrug-resistant tuberculosis increases lung damage. When patients complete their tuberculosis treatment, they should be evaluated as early as possible, and, if post-tuberculosis lung disease is diagnosed, they should be managed and offered pulmonary rehabilitation because there is evidence that it is effective in these patients.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.36416/1806-3756/e20210515
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv Jornal Brasileiro de Pneumologia v.48 n.2 2022
reponame:Jornal Brasileiro de Pneumologia (Online)
instname:Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
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reponame_str Jornal Brasileiro de Pneumologia (Online)
collection Jornal Brasileiro de Pneumologia (Online)
repository.name.fl_str_mv Jornal Brasileiro de Pneumologia (Online) - Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)
repository.mail.fl_str_mv ||jbp@jbp.org.br|| jpneumo@jornaldepneumologia.com.br
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