Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests

Detalhes bibliográficos
Autor(a) principal: Honorato,Sara B.
Data de Publicação: 2012
Outros Autores: Farfan,Silvia, Viana,Arnaldo, Filho,Josué M., Camarão,Gisela C., Fechine,Francisco V., Moraes,Maria E. A., Moraes,Manoel O., Ferro,Maribel, Dabbene,Viviana, Cuffini,Silvia L., Ayala,Alejandro P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005
Resumo: This study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets.
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spelling Polymorphism evaluation in generic tablets containing mebendazole by dissolution testsmebendazolepolymorphismsolubilityRaman spectroscopyX-ray powder diffractionThis study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets.Sociedade Brasileira de Química2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005Journal of the Brazilian Chemical Society v.23 n.2 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012000200005info:eu-repo/semantics/openAccessHonorato,Sara B.Farfan,SilviaViana,ArnaldoFilho,Josué M.Camarão,Gisela C.Fechine,Francisco V.Moraes,Maria E. A.Moraes,Manoel O.Ferro,MaribelDabbene,VivianaCuffini,Silvia L.Ayala,Alejandro P.eng2012-03-02T00:00:00Zoai:scielo:S0103-50532012000200005Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-03-02T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
title Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
spellingShingle Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
Honorato,Sara B.
mebendazole
polymorphism
solubility
Raman spectroscopy
X-ray powder diffraction
title_short Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
title_full Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
title_fullStr Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
title_full_unstemmed Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
title_sort Polymorphism evaluation in generic tablets containing mebendazole by dissolution tests
author Honorato,Sara B.
author_facet Honorato,Sara B.
Farfan,Silvia
Viana,Arnaldo
Filho,Josué M.
Camarão,Gisela C.
Fechine,Francisco V.
Moraes,Maria E. A.
Moraes,Manoel O.
Ferro,Maribel
Dabbene,Viviana
Cuffini,Silvia L.
Ayala,Alejandro P.
author_role author
author2 Farfan,Silvia
Viana,Arnaldo
Filho,Josué M.
Camarão,Gisela C.
Fechine,Francisco V.
Moraes,Maria E. A.
Moraes,Manoel O.
Ferro,Maribel
Dabbene,Viviana
Cuffini,Silvia L.
Ayala,Alejandro P.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Honorato,Sara B.
Farfan,Silvia
Viana,Arnaldo
Filho,Josué M.
Camarão,Gisela C.
Fechine,Francisco V.
Moraes,Maria E. A.
Moraes,Manoel O.
Ferro,Maribel
Dabbene,Viviana
Cuffini,Silvia L.
Ayala,Alejandro P.
dc.subject.por.fl_str_mv mebendazole
polymorphism
solubility
Raman spectroscopy
X-ray powder diffraction
topic mebendazole
polymorphism
solubility
Raman spectroscopy
X-ray powder diffraction
description This study evaluates the incidence of the polymorphic forms of mebendazole (MBZ) in tablets within the Brazilian market by dissolution tests. The indicated dissolution medium by the USP 30 (United States Pharmacopoeia) and a proposed modified medium were duly compared in order to verify whether they are able to discriminate the polymorph A from polymorph C in commercial tablets. Dissolution assay tests of physical mixtures in raw materials of polymorph A and polymorph C, as well as of nine tablets of MBZ (available in the Brazilian market), were properly performed. For the dissolution tests, the USP 30 medium (I) and a modified medium (II) were used. The modified medium allowed a reproducible and reliable quality control of MBZ polymorphism in commercial tablets.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532012000200005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.23 n.2 2012
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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