Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400018 |
Resumo: | This paper describes a systematic study of the voltammetric behavior of amfepramone at the hanging mercury drop electrode (HMDE) by cyclic (CV) and alternating current (AC) voltammetric methods. The studies showed the adsorptive behavior of amfepramone at the HMDE and were performed in H2SO4 0.1 mol L-1 (pH 1.0) and Ringer buffer (pH 11.0) as supporting electrolytes. The linear range for the amfepramone determination by differential pulse voltammetry (DPV) was 0.05 to 2.0 mg L-1 (r = 0.998) in acidic medium and 0.25 to 4.0 mg L-1 (r = 0.994) in alkaline medium. The relative standard deviation calculated was 2.5% and 4.0 % for five measurements of 0.5 mg L-1 amfepramone in acidic and alkaline medium, respectively. The detection limits calculated for the amfepramone determination in acidic and alkaline medium were 0.035 e 0.18 mg L-1, respectively.The methods were applied for the determination of amfepramone by DPV in tablets and capsules of pharmaceutical formulations used in the treatment of obesity. Recoveries values ranging from 90.0 to 101.0% for amfepramone added to synthetic mixtures containing fenproporex, mazindol, sibutramine, fluoxetine, caffeine, diazepam, and metformin as interferents prove the applicability of the method for its determination in the presence of other drugs normally added illegally to pharmaceutical formulations commercialized as natural medicaments. |
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Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulationsamfepramonevoltammetric behaviorpharmaceutical formulationsThis paper describes a systematic study of the voltammetric behavior of amfepramone at the hanging mercury drop electrode (HMDE) by cyclic (CV) and alternating current (AC) voltammetric methods. The studies showed the adsorptive behavior of amfepramone at the HMDE and were performed in H2SO4 0.1 mol L-1 (pH 1.0) and Ringer buffer (pH 11.0) as supporting electrolytes. The linear range for the amfepramone determination by differential pulse voltammetry (DPV) was 0.05 to 2.0 mg L-1 (r = 0.998) in acidic medium and 0.25 to 4.0 mg L-1 (r = 0.994) in alkaline medium. The relative standard deviation calculated was 2.5% and 4.0 % for five measurements of 0.5 mg L-1 amfepramone in acidic and alkaline medium, respectively. The detection limits calculated for the amfepramone determination in acidic and alkaline medium were 0.035 e 0.18 mg L-1, respectively.The methods were applied for the determination of amfepramone by DPV in tablets and capsules of pharmaceutical formulations used in the treatment of obesity. Recoveries values ranging from 90.0 to 101.0% for amfepramone added to synthetic mixtures containing fenproporex, mazindol, sibutramine, fluoxetine, caffeine, diazepam, and metformin as interferents prove the applicability of the method for its determination in the presence of other drugs normally added illegally to pharmaceutical formulations commercialized as natural medicaments.Sociedade Brasileira de Química2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400018Journal of the Brazilian Chemical Society v.18 n.4 2007reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532007000400018info:eu-repo/semantics/openAccessCarvalho,Leandro M. deNascimento,Paulo C. doBohrer,DeniseCorreia,DanieleBairros,André V. dePomblum,Valdeci J.Pomblum,Solange G.eng2007-09-18T00:00:00Zoai:scielo:S0103-50532007000400018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2007-09-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations |
title |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations |
spellingShingle |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations Carvalho,Leandro M. de amfepramone voltammetric behavior pharmaceutical formulations |
title_short |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations |
title_full |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations |
title_fullStr |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations |
title_full_unstemmed |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations |
title_sort |
Voltammetric behavior of amfepramone (diethylpropion) at the hanging mercury drop electrode and its analytical determination in pharmaceutical formulations |
author |
Carvalho,Leandro M. de |
author_facet |
Carvalho,Leandro M. de Nascimento,Paulo C. do Bohrer,Denise Correia,Daniele Bairros,André V. de Pomblum,Valdeci J. Pomblum,Solange G. |
author_role |
author |
author2 |
Nascimento,Paulo C. do Bohrer,Denise Correia,Daniele Bairros,André V. de Pomblum,Valdeci J. Pomblum,Solange G. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho,Leandro M. de Nascimento,Paulo C. do Bohrer,Denise Correia,Daniele Bairros,André V. de Pomblum,Valdeci J. Pomblum,Solange G. |
dc.subject.por.fl_str_mv |
amfepramone voltammetric behavior pharmaceutical formulations |
topic |
amfepramone voltammetric behavior pharmaceutical formulations |
description |
This paper describes a systematic study of the voltammetric behavior of amfepramone at the hanging mercury drop electrode (HMDE) by cyclic (CV) and alternating current (AC) voltammetric methods. The studies showed the adsorptive behavior of amfepramone at the HMDE and were performed in H2SO4 0.1 mol L-1 (pH 1.0) and Ringer buffer (pH 11.0) as supporting electrolytes. The linear range for the amfepramone determination by differential pulse voltammetry (DPV) was 0.05 to 2.0 mg L-1 (r = 0.998) in acidic medium and 0.25 to 4.0 mg L-1 (r = 0.994) in alkaline medium. The relative standard deviation calculated was 2.5% and 4.0 % for five measurements of 0.5 mg L-1 amfepramone in acidic and alkaline medium, respectively. The detection limits calculated for the amfepramone determination in acidic and alkaline medium were 0.035 e 0.18 mg L-1, respectively.The methods were applied for the determination of amfepramone by DPV in tablets and capsules of pharmaceutical formulations used in the treatment of obesity. Recoveries values ranging from 90.0 to 101.0% for amfepramone added to synthetic mixtures containing fenproporex, mazindol, sibutramine, fluoxetine, caffeine, diazepam, and metformin as interferents prove the applicability of the method for its determination in the presence of other drugs normally added illegally to pharmaceutical formulations commercialized as natural medicaments. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000400018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532007000400018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.18 n.4 2007 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318168152211456 |