Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form

Detalhes bibliográficos
Autor(a) principal: Vignaduzzo,Silvana E.
Data de Publicação: 2015
Outros Autores: Operto,María A., Castellano,Patricia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400729
Resumo: A dissolution test method and an analytical procedure by HPLC were developed and validated for the evaluation of the dissolution of tablets containing albendazole and praziquantel. Two different commercially tablets containing 500 mg of albendazole and 50 mg of praziquantel for veterinary use were selected for this study. A dissolution medium containing a mixture of 300 mL ethanol and 600 mL of 0.1 mol L-1 HCl was found suitable to ensure sink conditions. USP Apparatus 2, 900 mL dissolution medium and 75 rpm were fixed. Dissolution profiles were generated at 45 min. Dissolution samples were analyzed with a reversed-phase high-performance liquid chromatography (RP-HPLC) method with ultraviolet (UV) detection at 210 nm, developed and validated for this purpose. Each product was also assayed for analyte content according to USP 35. The dissolution test described here could be proposed as a means of assessing finished product quality.
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spelling Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Formdissolution testalbendazolepraziquanteltabletsHPLCA dissolution test method and an analytical procedure by HPLC were developed and validated for the evaluation of the dissolution of tablets containing albendazole and praziquantel. Two different commercially tablets containing 500 mg of albendazole and 50 mg of praziquantel for veterinary use were selected for this study. A dissolution medium containing a mixture of 300 mL ethanol and 600 mL of 0.1 mol L-1 HCl was found suitable to ensure sink conditions. USP Apparatus 2, 900 mL dissolution medium and 75 rpm were fixed. Dissolution profiles were generated at 45 min. Dissolution samples were analyzed with a reversed-phase high-performance liquid chromatography (RP-HPLC) method with ultraviolet (UV) detection at 210 nm, developed and validated for this purpose. Each product was also assayed for analyte content according to USP 35. The dissolution test described here could be proposed as a means of assessing finished product quality.Sociedade Brasileira de Química2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400729Journal of the Brazilian Chemical Society v.26 n.4 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150033info:eu-repo/semantics/openAccessVignaduzzo,Silvana E.Operto,María A.Castellano,Patricia M.eng2015-05-11T00:00:00Zoai:scielo:S0103-50532015000400729Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-05-11T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
title Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
spellingShingle Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
Vignaduzzo,Silvana E.
dissolution test
albendazole
praziquantel
tablets
HPLC
title_short Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
title_full Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
title_fullStr Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
title_full_unstemmed Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
title_sort Development and Validation of a Dissolution Test Method for Albendazole and Praziquantel in Their Combined Dosage Form
author Vignaduzzo,Silvana E.
author_facet Vignaduzzo,Silvana E.
Operto,María A.
Castellano,Patricia M.
author_role author
author2 Operto,María A.
Castellano,Patricia M.
author2_role author
author
dc.contributor.author.fl_str_mv Vignaduzzo,Silvana E.
Operto,María A.
Castellano,Patricia M.
dc.subject.por.fl_str_mv dissolution test
albendazole
praziquantel
tablets
HPLC
topic dissolution test
albendazole
praziquantel
tablets
HPLC
description A dissolution test method and an analytical procedure by HPLC were developed and validated for the evaluation of the dissolution of tablets containing albendazole and praziquantel. Two different commercially tablets containing 500 mg of albendazole and 50 mg of praziquantel for veterinary use were selected for this study. A dissolution medium containing a mixture of 300 mL ethanol and 600 mL of 0.1 mol L-1 HCl was found suitable to ensure sink conditions. USP Apparatus 2, 900 mL dissolution medium and 75 rpm were fixed. Dissolution profiles were generated at 45 min. Dissolution samples were analyzed with a reversed-phase high-performance liquid chromatography (RP-HPLC) method with ultraviolet (UV) detection at 210 nm, developed and validated for this purpose. Each product was also assayed for analyte content according to USP 35. The dissolution test described here could be proposed as a means of assessing finished product quality.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400729
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000400729
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20150033
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.26 n.4 2015
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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