Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets

Detalhes bibliográficos
Autor(a) principal: Marques-Marinho,Flávia Dias
Data de Publicação: 2012
Outros Autores: Santos,Amanda Leão dos, Vianna-Soares,Cristina Duarte, Reis,Ilka Afonso, Zanon,José Carlos da Costa, Lima,Angélica Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600031
Resumo: Commonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate buffer with 0.5% SDS, pH 7, respectively. Dissolution test aliquots did not go through sample treatment, as described in USP SIM tablets monograph by ultraviolet spectrophotometry. The proposed method is fast, simple, feasible and robust.
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spelling Simvastatin assay and dissolution studies by feasible RP-HPLC in tabletsSimvastatin tabletsdissolution studiesRP-HPLCCommonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate buffer with 0.5% SDS, pH 7, respectively. Dissolution test aliquots did not go through sample treatment, as described in USP SIM tablets monograph by ultraviolet spectrophotometry. The proposed method is fast, simple, feasible and robust.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600031Química Nova v.35 n.6 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000600031info:eu-repo/semantics/openAccessMarques-Marinho,Flávia DiasSantos,Amanda Leão dosVianna-Soares,Cristina DuarteReis,Ilka AfonsoZanon,José Carlos da CostaLima,Angélica Alveseng2012-07-25T00:00:00Zoai:scielo:S0100-40422012000600031Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-07-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
title Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
spellingShingle Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
Marques-Marinho,Flávia Dias
Simvastatin tablets
dissolution studies
RP-HPLC
title_short Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
title_full Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
title_fullStr Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
title_full_unstemmed Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
title_sort Simvastatin assay and dissolution studies by feasible RP-HPLC in tablets
author Marques-Marinho,Flávia Dias
author_facet Marques-Marinho,Flávia Dias
Santos,Amanda Leão dos
Vianna-Soares,Cristina Duarte
Reis,Ilka Afonso
Zanon,José Carlos da Costa
Lima,Angélica Alves
author_role author
author2 Santos,Amanda Leão dos
Vianna-Soares,Cristina Duarte
Reis,Ilka Afonso
Zanon,José Carlos da Costa
Lima,Angélica Alves
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marques-Marinho,Flávia Dias
Santos,Amanda Leão dos
Vianna-Soares,Cristina Duarte
Reis,Ilka Afonso
Zanon,José Carlos da Costa
Lima,Angélica Alves
dc.subject.por.fl_str_mv Simvastatin tablets
dissolution studies
RP-HPLC
topic Simvastatin tablets
dissolution studies
RP-HPLC
description Commonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate buffer with 0.5% SDS, pH 7, respectively. Dissolution test aliquots did not go through sample treatment, as described in USP SIM tablets monograph by ultraviolet spectrophotometry. The proposed method is fast, simple, feasible and robust.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600031
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600031
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000600031
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.6 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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