Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000701447 |
Resumo: | Fluoroquinolones antimicrobials are partially excreted in natura after administration. Their occurrence was investigated in hospital raw sewage (HRS) and treated wastewater (TW) using an online solid phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method (SPE-UHPLC-MS/MS). The analytical curves ranged from 0.25 to 46 ng mL-1 and the matrix effect, assessed for marbofloxacin and lomefloxacin, ranged from –63 to +1%. All HRS samples contained ciprofloxacin (1-34 ng mL-1) and ofloxacin (0.9-27 ng mL-1), while norfloxacin was detected in 17% of the samples (0.8-4.4 ng mL-1). Only ciprofloxacin (0.5-5.6 ng mL-1) was detected in TW samples. The antimicrobial activity of the HRS samples for E. coli was higher than a ciprofloxacin solution of 1 mg L-1, due to the presence of other antimicrobial agents. Ozonation (10 mg O3 L-1 min-1 ; 10 min) degraded up to 84% of the fluoroquinolones and removed the antimicrobial activity of HRS samples. |
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Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluationfluoroquinoloneshospital wastewaterSPE-UHPLC-MS/MSantimicrobial activityadvanced oxidationFluoroquinolones antimicrobials are partially excreted in natura after administration. Their occurrence was investigated in hospital raw sewage (HRS) and treated wastewater (TW) using an online solid phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method (SPE-UHPLC-MS/MS). The analytical curves ranged from 0.25 to 46 ng mL-1 and the matrix effect, assessed for marbofloxacin and lomefloxacin, ranged from –63 to +1%. All HRS samples contained ciprofloxacin (1-34 ng mL-1) and ofloxacin (0.9-27 ng mL-1), while norfloxacin was detected in 17% of the samples (0.8-4.4 ng mL-1). Only ciprofloxacin (0.5-5.6 ng mL-1) was detected in TW samples. The antimicrobial activity of the HRS samples for E. coli was higher than a ciprofloxacin solution of 1 mg L-1, due to the presence of other antimicrobial agents. Ozonation (10 mg O3 L-1 min-1 ; 10 min) degraded up to 84% of the fluoroquinolones and removed the antimicrobial activity of HRS samples.Sociedade Brasileira de Química2019-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000701447Journal of the Brazilian Chemical Society v.30 n.7 2019reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190040info:eu-repo/semantics/openAccessRodrigues-Silva,CaioPorto,Rafael S.Santos,Sabrina G. dosSchneider,JerusaRath,Susanneeng2019-07-01T00:00:00Zoai:scielo:S0103-50532019000701447Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2019-07-01T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation |
title |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation |
spellingShingle |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation Rodrigues-Silva,Caio fluoroquinolones hospital wastewater SPE-UHPLC-MS/MS antimicrobial activity advanced oxidation |
title_short |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation |
title_full |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation |
title_fullStr |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation |
title_full_unstemmed |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation |
title_sort |
Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation |
author |
Rodrigues-Silva,Caio |
author_facet |
Rodrigues-Silva,Caio Porto,Rafael S. Santos,Sabrina G. dos Schneider,Jerusa Rath,Susanne |
author_role |
author |
author2 |
Porto,Rafael S. Santos,Sabrina G. dos Schneider,Jerusa Rath,Susanne |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues-Silva,Caio Porto,Rafael S. Santos,Sabrina G. dos Schneider,Jerusa Rath,Susanne |
dc.subject.por.fl_str_mv |
fluoroquinolones hospital wastewater SPE-UHPLC-MS/MS antimicrobial activity advanced oxidation |
topic |
fluoroquinolones hospital wastewater SPE-UHPLC-MS/MS antimicrobial activity advanced oxidation |
description |
Fluoroquinolones antimicrobials are partially excreted in natura after administration. Their occurrence was investigated in hospital raw sewage (HRS) and treated wastewater (TW) using an online solid phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method (SPE-UHPLC-MS/MS). The analytical curves ranged from 0.25 to 46 ng mL-1 and the matrix effect, assessed for marbofloxacin and lomefloxacin, ranged from –63 to +1%. All HRS samples contained ciprofloxacin (1-34 ng mL-1) and ofloxacin (0.9-27 ng mL-1), while norfloxacin was detected in 17% of the samples (0.8-4.4 ng mL-1). Only ciprofloxacin (0.5-5.6 ng mL-1) was detected in TW samples. The antimicrobial activity of the HRS samples for E. coli was higher than a ciprofloxacin solution of 1 mg L-1, due to the presence of other antimicrobial agents. Ozonation (10 mg O3 L-1 min-1 ; 10 min) degraded up to 84% of the fluoroquinolones and removed the antimicrobial activity of HRS samples. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000701447 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532019000701447 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20190040 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.30 n.7 2019 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318182053183488 |