Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids

Detalhes bibliográficos
Autor(a) principal: Cai,Lin
Data de Publicação: 2020
Outros Autores: Hou,Wen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000500982
Resumo: In this study, we successfully demonstrated a strategy for specific disulfide bond formation by hybridization of two complementary peptide nucleic acid strands. Peptides were linked to the pair of complementary peptide nucleic acids by native chemical ligation, respectively, and base pairing drove the two peptides into close proximity for interchain disulfide bond formation. Since peptide nucleic acids directed system is easier to manipulate than deoxyribonucleic acid system, this system will be more useful and have a broader application scope in the construction of complex biomolecular structures.
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spelling Specific Disulfide Bond Formation Directed by Peptide Nucleic Acidspeptide nucleic aciddisulfide bondheterodimerizationIn this study, we successfully demonstrated a strategy for specific disulfide bond formation by hybridization of two complementary peptide nucleic acid strands. Peptides were linked to the pair of complementary peptide nucleic acids by native chemical ligation, respectively, and base pairing drove the two peptides into close proximity for interchain disulfide bond formation. Since peptide nucleic acids directed system is easier to manipulate than deoxyribonucleic acid system, this system will be more useful and have a broader application scope in the construction of complex biomolecular structures.Sociedade Brasileira de Química2020-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000500982Journal of the Brazilian Chemical Society v.31 n.5 2020reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20190263info:eu-repo/semantics/openAccessCai,LinHou,Weneng2020-04-27T00:00:00Zoai:scielo:S0103-50532020000500982Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2020-04-27T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
title Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
spellingShingle Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
Cai,Lin
peptide nucleic acid
disulfide bond
heterodimerization
title_short Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
title_full Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
title_fullStr Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
title_full_unstemmed Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
title_sort Specific Disulfide Bond Formation Directed by Peptide Nucleic Acids
author Cai,Lin
author_facet Cai,Lin
Hou,Wen
author_role author
author2 Hou,Wen
author2_role author
dc.contributor.author.fl_str_mv Cai,Lin
Hou,Wen
dc.subject.por.fl_str_mv peptide nucleic acid
disulfide bond
heterodimerization
topic peptide nucleic acid
disulfide bond
heterodimerization
description In this study, we successfully demonstrated a strategy for specific disulfide bond formation by hybridization of two complementary peptide nucleic acid strands. Peptides were linked to the pair of complementary peptide nucleic acids by native chemical ligation, respectively, and base pairing drove the two peptides into close proximity for interchain disulfide bond formation. Since peptide nucleic acids directed system is easier to manipulate than deoxyribonucleic acid system, this system will be more useful and have a broader application scope in the construction of complex biomolecular structures.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000500982
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000500982
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20190263
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.31 n.5 2020
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
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institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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