Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn)
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000900023 |
Resumo: | In mass spectrometric (MS) systems with electrospray ionization (ESI), the sample can be analyzed coupled to separation systems (such as liquid chromatography or capillary electrophoresis) or simply by direct infusion. The greatest benefit of the type of injection is the possibility of continuous use of small amounts of samples over a long period of time. This extended analysis time allows a complete study of fragmentation by mass spectrometry, which is critical for structure elucidation of new compounds, or when using an ion trap mass analyzer. The injector filled with the sample is placed at the ESI source inlet creating an electric field suitable for the continuous formation of a spray (solvent and sample) and consequently, the gradual and even release of the sample. For the formation of the spray, is necessary that the injector end is metalized. The formation of a bilayer of titanium and gold provided an excellent attachment of the film, resulting in a nanoinjector for ionization/spray formation in the system for MS. The nanoinjectors showed high repeatability and stability over 100 min by continuous sampling with 10 µL of sample. |
id |
SBQ-2_9fba26955ce6875d4e2093dba76c7e41 |
---|---|
oai_identifier_str |
oai:scielo:S0103-50532012000900023 |
network_acronym_str |
SBQ-2 |
network_name_str |
Journal of the Brazilian Chemical Society (Online) |
repository_id_str |
|
spelling |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn)mass spectrometrynanoinjectormicrosystemsIn mass spectrometric (MS) systems with electrospray ionization (ESI), the sample can be analyzed coupled to separation systems (such as liquid chromatography or capillary electrophoresis) or simply by direct infusion. The greatest benefit of the type of injection is the possibility of continuous use of small amounts of samples over a long period of time. This extended analysis time allows a complete study of fragmentation by mass spectrometry, which is critical for structure elucidation of new compounds, or when using an ion trap mass analyzer. The injector filled with the sample is placed at the ESI source inlet creating an electric field suitable for the continuous formation of a spray (solvent and sample) and consequently, the gradual and even release of the sample. For the formation of the spray, is necessary that the injector end is metalized. The formation of a bilayer of titanium and gold provided an excellent attachment of the film, resulting in a nanoinjector for ionization/spray formation in the system for MS. The nanoinjectors showed high repeatability and stability over 100 min by continuous sampling with 10 µL of sample.Sociedade Brasileira de Química2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000900023Journal of the Brazilian Chemical Society v.23 n.9 2012reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532012005000036info:eu-repo/semantics/openAccessAssunção,Nilson A.Nakayasu,Ernesto S.Daffre,SirleiCarrilho,Emanueleng2012-10-15T00:00:00Zoai:scielo:S0103-50532012000900023Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2012-10-15T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) |
title |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) |
spellingShingle |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) Assunção,Nilson A. mass spectrometry nanoinjector microsystems |
title_short |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) |
title_full |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) |
title_fullStr |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) |
title_full_unstemmed |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) |
title_sort |
Development of nanoinjector devices for electrospray ionization - tandem mass spectrometry (ESI-MSn) |
author |
Assunção,Nilson A. |
author_facet |
Assunção,Nilson A. Nakayasu,Ernesto S. Daffre,Sirlei Carrilho,Emanuel |
author_role |
author |
author2 |
Nakayasu,Ernesto S. Daffre,Sirlei Carrilho,Emanuel |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Assunção,Nilson A. Nakayasu,Ernesto S. Daffre,Sirlei Carrilho,Emanuel |
dc.subject.por.fl_str_mv |
mass spectrometry nanoinjector microsystems |
topic |
mass spectrometry nanoinjector microsystems |
description |
In mass spectrometric (MS) systems with electrospray ionization (ESI), the sample can be analyzed coupled to separation systems (such as liquid chromatography or capillary electrophoresis) or simply by direct infusion. The greatest benefit of the type of injection is the possibility of continuous use of small amounts of samples over a long period of time. This extended analysis time allows a complete study of fragmentation by mass spectrometry, which is critical for structure elucidation of new compounds, or when using an ion trap mass analyzer. The injector filled with the sample is placed at the ESI source inlet creating an electric field suitable for the continuous formation of a spray (solvent and sample) and consequently, the gradual and even release of the sample. For the formation of the spray, is necessary that the injector end is metalized. The formation of a bilayer of titanium and gold provided an excellent attachment of the film, resulting in a nanoinjector for ionization/spray formation in the system for MS. The nanoinjectors showed high repeatability and stability over 100 min by continuous sampling with 10 µL of sample. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000900023 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532012000900023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532012005000036 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.23 n.9 2012 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318174350344192 |