An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines

Detalhes bibliográficos
Autor(a) principal: Silva,Maria Joselice e
Data de Publicação: 2005
Outros Autores: Cottier,Louis, Srivastava,Rajendra M., Sinou,Denis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000600017
Resumo: An easy and efficient route for the synthesis of enantiomerically pure beta-aminoketones 5a, 6 and gamma-aminoalcohols 1a, 2a, 3, 4 from L-prolinol 7 and L-proline 15 is described. One of the key steps is the use of Tebbe's reagent allowing the transformation of the ester function to an enol ether without any racemization.
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spelling An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidinesbeta-aminoketonesgamma-aminoalcoholsracemizationTebbe's reagentAn easy and efficient route for the synthesis of enantiomerically pure beta-aminoketones 5a, 6 and gamma-aminoalcohols 1a, 2a, 3, 4 from L-prolinol 7 and L-proline 15 is described. One of the key steps is the use of Tebbe's reagent allowing the transformation of the ester function to an enol ether without any racemization.Sociedade Brasileira de Química2005-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000600017Journal of the Brazilian Chemical Society v.16 n.5 2005reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532005000600017info:eu-repo/semantics/openAccessSilva,Maria Joselice eCottier,LouisSrivastava,Rajendra M.Sinou,Deniseng2005-11-09T00:00:00Zoai:scielo:S0103-50532005000600017Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2005-11-09T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
title An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
spellingShingle An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
Silva,Maria Joselice e
beta-aminoketones
gamma-aminoalcohols
racemization
Tebbe's reagent
title_short An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
title_full An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
title_fullStr An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
title_full_unstemmed An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
title_sort An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines
author Silva,Maria Joselice e
author_facet Silva,Maria Joselice e
Cottier,Louis
Srivastava,Rajendra M.
Sinou,Denis
author_role author
author2 Cottier,Louis
Srivastava,Rajendra M.
Sinou,Denis
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Maria Joselice e
Cottier,Louis
Srivastava,Rajendra M.
Sinou,Denis
dc.subject.por.fl_str_mv beta-aminoketones
gamma-aminoalcohols
racemization
Tebbe's reagent
topic beta-aminoketones
gamma-aminoalcohols
racemization
Tebbe's reagent
description An easy and efficient route for the synthesis of enantiomerically pure beta-aminoketones 5a, 6 and gamma-aminoalcohols 1a, 2a, 3, 4 from L-prolinol 7 and L-proline 15 is described. One of the key steps is the use of Tebbe's reagent allowing the transformation of the ester function to an enol ether without any racemization.
publishDate 2005
dc.date.none.fl_str_mv 2005-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000600017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000600017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532005000600017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.16 n.5 2005
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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