Multivariate spectroscopic determination of the lamivudine-zidovudine association

Detalhes bibliográficos
Autor(a) principal: Cordeiro, Gilcélia Aparecida
Data de Publicação: 2011
Outros Autores: Nagata, Noemi, Messerschmidt, Iara, Peralta-Zamora, Patricio, Rodrigues, Leticia Norma Carpentieri [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/00130000099qq
DOI: 10.1590/S0103-50532011000200020
Texto Completo: http://dx.doi.org/10.1590/S0103-50532011000200020
http://repositorio.unifesp.br/handle/11600/6274
Resumo: The multivariate spectroscopic determination of lamivudine-zidovudine associations was carried out by partial least square regression (PLS). This model was developed from 20 synthetic mixtures using mean-centered spectral data acquired from 190 to 350 nm and with 3 latent variables. External validation was performed with 6 synthetic mixtures providing prediction errors close to 1%. Moreover, the analysis of commercial drugs showed good results with prediction errors lower than 10%. The multivariate methodology was validated according to International Conference on Harmonization (ICH) criteria, demonstrating precision, accuracy and robustness within legal requirements.
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spelling Multivariate spectroscopic determination of the lamivudine-zidovudine associationlamivudinezidovudineelectronic spectroscopymultivariate calibrationThe multivariate spectroscopic determination of lamivudine-zidovudine associations was carried out by partial least square regression (PLS). This model was developed from 20 synthetic mixtures using mean-centered spectral data acquired from 190 to 350 nm and with 3 latent variables. External validation was performed with 6 synthetic mixtures providing prediction errors close to 1%. Moreover, the analysis of commercial drugs showed good results with prediction errors lower than 10%. The multivariate methodology was validated according to International Conference on Harmonization (ICH) criteria, demonstrating precision, accuracy and robustness within legal requirements.A determinação espectroscópica multivariada da associação lamivudina-zidovudina foi realizada por regressão de mínimos quadrados parciais. O modelo foi desenvolvido a partir de 20 misturas sintéticas utilizando-se dados espectrais centrados na média adquiridos entre 190 e 350 nm e 3 variáveis latentes. A validação externa foi realizada a partir de 6 misturas sintéticas, observando-se erros médios de previsão de aproximadamente 1%. Na análise de medicamentos foram obtidos bons resultados, com erros de previsão inferiores a 10%. A metodologia multivariada foi validada de acordo com os critérios do International Conference on Harmonization (ICH), demonstrando precisão, exatidão e robustez compatíveis com a legislação vigente.Universidade Federal do Paraná Departamento de QuímicaUniversidade Federal de São Paulo (UNIFESP) Departamento de Ciências Exatas e da TerraUNIFESP, Depto. de Ciências Exatas e da TerraSciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sociedade Brasileira de QuímicaUniversidade Federal do Paraná Departamento de QuímicaUniversidade Federal de São Paulo (UNIFESP)Cordeiro, Gilcélia AparecidaNagata, NoemiMesserschmidt, IaraPeralta-Zamora, PatricioRodrigues, Leticia Norma Carpentieri [UNIFESP]2015-06-14T13:42:53Z2015-06-14T13:42:53Z2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion337-343application/pdfhttp://dx.doi.org/10.1590/S0103-50532011000200020Journal of the Brazilian Chemical Society. Sociedade Brasileira de Química, v. 22, n. 2, p. 337-343, 2011.10.1590/S0103-50532011000200020S0103-50532011000200020.pdf0103-5053S0103-50532011000200020http://repositorio.unifesp.br/handle/11600/6274WOS:000287990700020ark:/48912/00130000099qqengJournal of the Brazilian Chemical Societyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T21:27:32Zoai:repositorio.unifesp.br/:11600/6274Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:06:46.578663Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Multivariate spectroscopic determination of the lamivudine-zidovudine association
title Multivariate spectroscopic determination of the lamivudine-zidovudine association
spellingShingle Multivariate spectroscopic determination of the lamivudine-zidovudine association
Multivariate spectroscopic determination of the lamivudine-zidovudine association
Cordeiro, Gilcélia Aparecida
lamivudine
zidovudine
electronic spectroscopy
multivariate calibration
Cordeiro, Gilcélia Aparecida
lamivudine
zidovudine
electronic spectroscopy
multivariate calibration
title_short Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_full Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_fullStr Multivariate spectroscopic determination of the lamivudine-zidovudine association
Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_full_unstemmed Multivariate spectroscopic determination of the lamivudine-zidovudine association
Multivariate spectroscopic determination of the lamivudine-zidovudine association
title_sort Multivariate spectroscopic determination of the lamivudine-zidovudine association
author Cordeiro, Gilcélia Aparecida
author_facet Cordeiro, Gilcélia Aparecida
Cordeiro, Gilcélia Aparecida
Nagata, Noemi
Messerschmidt, Iara
Peralta-Zamora, Patricio
Rodrigues, Leticia Norma Carpentieri [UNIFESP]
Nagata, Noemi
Messerschmidt, Iara
Peralta-Zamora, Patricio
Rodrigues, Leticia Norma Carpentieri [UNIFESP]
author_role author
author2 Nagata, Noemi
Messerschmidt, Iara
Peralta-Zamora, Patricio
Rodrigues, Leticia Norma Carpentieri [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Paraná Departamento de Química
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Cordeiro, Gilcélia Aparecida
Nagata, Noemi
Messerschmidt, Iara
Peralta-Zamora, Patricio
Rodrigues, Leticia Norma Carpentieri [UNIFESP]
dc.subject.por.fl_str_mv lamivudine
zidovudine
electronic spectroscopy
multivariate calibration
topic lamivudine
zidovudine
electronic spectroscopy
multivariate calibration
description The multivariate spectroscopic determination of lamivudine-zidovudine associations was carried out by partial least square regression (PLS). This model was developed from 20 synthetic mixtures using mean-centered spectral data acquired from 190 to 350 nm and with 3 latent variables. External validation was performed with 6 synthetic mixtures providing prediction errors close to 1%. Moreover, the analysis of commercial drugs showed good results with prediction errors lower than 10%. The multivariate methodology was validated according to International Conference on Harmonization (ICH) criteria, demonstrating precision, accuracy and robustness within legal requirements.
publishDate 2011
dc.date.none.fl_str_mv 2011-02-01
2015-06-14T13:42:53Z
2015-06-14T13:42:53Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-50532011000200020
Journal of the Brazilian Chemical Society. Sociedade Brasileira de Química, v. 22, n. 2, p. 337-343, 2011.
10.1590/S0103-50532011000200020
S0103-50532011000200020.pdf
0103-5053
S0103-50532011000200020
http://repositorio.unifesp.br/handle/11600/6274
WOS:000287990700020
dc.identifier.dark.fl_str_mv ark:/48912/00130000099qq
url http://dx.doi.org/10.1590/S0103-50532011000200020
http://repositorio.unifesp.br/handle/11600/6274
identifier_str_mv Journal of the Brazilian Chemical Society. Sociedade Brasileira de Química, v. 22, n. 2, p. 337-343, 2011.
10.1590/S0103-50532011000200020
S0103-50532011000200020.pdf
0103-5053
S0103-50532011000200020
WOS:000287990700020
ark:/48912/00130000099qq
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of the Brazilian Chemical Society
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 337-343
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822250046820712448
dc.identifier.doi.none.fl_str_mv 10.1590/S0103-50532011000200020

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