Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)

Detalhes bibliográficos
Autor(a) principal: Pavan,Fernando Rogério
Data de Publicação: 2009
Outros Autores: Leite,Clarice Queico Fujimura, Coelho,Roberta Gomes, Coutinho,Isabel Duarte, Honda,Neli Kika, Cardoso,Claudia Andréa Lima, Vilegas,Wagner, Leite,Sergio Roberto de Andrade, Sato,Daisy Nakamura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026
Resumo: The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
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spelling Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)Campomanesia adamantiumanti-Mycobacterium tuberculosisflavonoidsThe anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026Química Nova v.32 n.5 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000500026info:eu-repo/semantics/openAccessPavan,Fernando RogérioLeite,Clarice Queico FujimuraCoelho,Roberta GomesCoutinho,Isabel DuarteHonda,Neli KikaCardoso,Claudia Andréa LimaVilegas,WagnerLeite,Sergio Roberto de AndradeSato,Daisy Nakamuraeng2009-07-30T00:00:00Zoai:scielo:S0100-40422009000500026Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-07-30T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
spellingShingle Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
Pavan,Fernando Rogério
Campomanesia adamantium
anti-Mycobacterium tuberculosis
flavonoids
title_short Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_full Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_fullStr Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_full_unstemmed Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_sort Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
author Pavan,Fernando Rogério
author_facet Pavan,Fernando Rogério
Leite,Clarice Queico Fujimura
Coelho,Roberta Gomes
Coutinho,Isabel Duarte
Honda,Neli Kika
Cardoso,Claudia Andréa Lima
Vilegas,Wagner
Leite,Sergio Roberto de Andrade
Sato,Daisy Nakamura
author_role author
author2 Leite,Clarice Queico Fujimura
Coelho,Roberta Gomes
Coutinho,Isabel Duarte
Honda,Neli Kika
Cardoso,Claudia Andréa Lima
Vilegas,Wagner
Leite,Sergio Roberto de Andrade
Sato,Daisy Nakamura
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pavan,Fernando Rogério
Leite,Clarice Queico Fujimura
Coelho,Roberta Gomes
Coutinho,Isabel Duarte
Honda,Neli Kika
Cardoso,Claudia Andréa Lima
Vilegas,Wagner
Leite,Sergio Roberto de Andrade
Sato,Daisy Nakamura
dc.subject.por.fl_str_mv Campomanesia adamantium
anti-Mycobacterium tuberculosis
flavonoids
topic Campomanesia adamantium
anti-Mycobacterium tuberculosis
flavonoids
description The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000500026
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.5 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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