Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)

• Autor(a) principal: Pavan, Fernando Rogério [UNESP]
• Data de Publicação: 2009
• Outros Autores: Leite, Clarice Queico Fujimura [UNESP], Coelho, Roberta Gomes, Coutinho, Isabel Duarte, Honda, Neli Kika, Cardoso, Claudia Andréa Lima, Vilegas, Wagner [UNESP], Leite, Sergio Roberto de Andrade [UNESP], Sato, Daisy Nakamura
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1590/S0100-40422009000500026
• Texto Completo: http://dx.doi.org/10.1590/S0100-40422009000500026; http://hdl.handle.net/11449/8029
• topic: Campomanesia adamantium; anti-Mycobacterium tuberculosis; flavonoids

The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.