Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)

Detalhes bibliográficos
Autor(a) principal: Pavan, Fernando Rogério
Data de Publicação: 2009
Outros Autores: Leite, Clarice Queico Fujimura, Coelho, Roberta Gomes, Coutinho, Isabel Duarte, Honda, Neli Kika, Cardoso, Cláudia Andréa Lima, Vilegas, Wagner, Leite, Sergio Roberto de Andrade, Sato, Daisy Nakamura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMS
Texto Completo: https://repositorio.ufms.br/handle/123456789/914
http://dx.doi.org/10.1590/S0100-40422009000500026
Resumo: The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
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spelling 2011-11-28T19:43:32Z2021-09-30T19:55:13Z2009PAVAN, Fernando Rogério et al . Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae). Quím. Nova, São Paulo, v. 32, n. 5, 2009 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S0100-40422009000500026.https://repositorio.ufms.br/handle/123456789/914http://dx.doi.org/10.1590/S0100-40422009000500026The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. 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dc.title.pt_BR.fl_str_mv Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
spellingShingle Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
Pavan, Fernando Rogério
Myrtaceae
Tuberculose
Flavonóides
Tuberculosis
Flavonoids
title_short Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_full Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_fullStr Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_full_unstemmed Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
title_sort Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
author Pavan, Fernando Rogério
author_facet Pavan, Fernando Rogério
Leite, Clarice Queico Fujimura
Coelho, Roberta Gomes
Coutinho, Isabel Duarte
Honda, Neli Kika
Cardoso, Cláudia Andréa Lima
Vilegas, Wagner
Leite, Sergio Roberto de Andrade
Sato, Daisy Nakamura
author_role author
author2 Leite, Clarice Queico Fujimura
Coelho, Roberta Gomes
Coutinho, Isabel Duarte
Honda, Neli Kika
Cardoso, Cláudia Andréa Lima
Vilegas, Wagner
Leite, Sergio Roberto de Andrade
Sato, Daisy Nakamura
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pavan, Fernando Rogério
Leite, Clarice Queico Fujimura
Coelho, Roberta Gomes
Coutinho, Isabel Duarte
Honda, Neli Kika
Cardoso, Cláudia Andréa Lima
Vilegas, Wagner
Leite, Sergio Roberto de Andrade
Sato, Daisy Nakamura
dc.subject.por.fl_str_mv Myrtaceae
Tuberculose
Flavonóides
Tuberculosis
Flavonoids
topic Myrtaceae
Tuberculose
Flavonóides
Tuberculosis
Flavonoids
description The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-11-28T19:43:32Z
dc.date.available.fl_str_mv 2021-09-30T19:55:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv PAVAN, Fernando Rogério et al . Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae). Quím. Nova, São Paulo, v. 32, n. 5, 2009 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S0100-40422009000500026.
dc.identifier.uri.fl_str_mv https://repositorio.ufms.br/handle/123456789/914
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0100-40422009000500026
identifier_str_mv PAVAN, Fernando Rogério et al . Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae). Quím. Nova, São Paulo, v. 32, n. 5, 2009 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S0100-40422009000500026.
url https://repositorio.ufms.br/handle/123456789/914
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publisher.none.fl_str_mv Química Nova
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