Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMS |
Texto Completo: | https://repositorio.ufms.br/handle/123456789/914 http://dx.doi.org/10.1590/S0100-40422009000500026 |
Resumo: | The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them. |
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2011-11-28T19:43:32Z2021-09-30T19:55:13Z2009PAVAN, Fernando Rogério et al . Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae). Quím. Nova, São Paulo, v. 32, n. 5, 2009 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S0100-40422009000500026.https://repositorio.ufms.br/handle/123456789/914http://dx.doi.org/10.1590/S0100-40422009000500026The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.engQuímica NovaMyrtaceaeTuberculoseFlavonóidesTuberculosisFlavonoidsEvaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePavan, Fernando RogérioLeite, Clarice Queico FujimuraCoelho, Roberta GomesCoutinho, Isabel DuarteHonda, Neli KikaCardoso, Cláudia Andréa LimaVilegas, WagnerLeite, Sergio Roberto de AndradeSato, Daisy Nakamurainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSTHUMBNAILEvaluation of anti-mycobacterium.pdf.jpgEvaluation of anti-mycobacterium.pdf.jpgGenerated Thumbnailimage/jpeg1640https://repositorio.ufms.br/bitstream/123456789/914/4/Evaluation%20of%20anti-mycobacterium.pdf.jpgbf9a99e5c30c138efd5943969e8b3ab9MD54ORIGINALEvaluation of anti-mycobacterium.pdfEvaluation of anti-mycobacterium.pdfapplication/pdf165782https://repositorio.ufms.br/bitstream/123456789/914/1/Evaluation%20of%20anti-mycobacterium.pdfc3285d4ad44af1848db02a843a92a85eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufms.br/bitstream/123456789/914/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTEvaluation of anti-mycobacterium.pdf.txtEvaluation of anti-mycobacterium.pdf.txtExtracted texttext/plain25824https://repositorio.ufms.br/bitstream/123456789/914/3/Evaluation%20of%20anti-mycobacterium.pdf.txt7faf54966f77e1a0a0935a2c17f08fb0MD53123456789/9142021-09-30 15:55:13.917oai:repositorio.ufms.br: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Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242021-09-30T19:55:13Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) |
title |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) |
spellingShingle |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) Pavan, Fernando Rogério Myrtaceae Tuberculose Flavonóides Tuberculosis Flavonoids |
title_short |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) |
title_full |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) |
title_fullStr |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) |
title_full_unstemmed |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) |
title_sort |
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae) |
author |
Pavan, Fernando Rogério |
author_facet |
Pavan, Fernando Rogério Leite, Clarice Queico Fujimura Coelho, Roberta Gomes Coutinho, Isabel Duarte Honda, Neli Kika Cardoso, Cláudia Andréa Lima Vilegas, Wagner Leite, Sergio Roberto de Andrade Sato, Daisy Nakamura |
author_role |
author |
author2 |
Leite, Clarice Queico Fujimura Coelho, Roberta Gomes Coutinho, Isabel Duarte Honda, Neli Kika Cardoso, Cláudia Andréa Lima Vilegas, Wagner Leite, Sergio Roberto de Andrade Sato, Daisy Nakamura |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pavan, Fernando Rogério Leite, Clarice Queico Fujimura Coelho, Roberta Gomes Coutinho, Isabel Duarte Honda, Neli Kika Cardoso, Cláudia Andréa Lima Vilegas, Wagner Leite, Sergio Roberto de Andrade Sato, Daisy Nakamura |
dc.subject.por.fl_str_mv |
Myrtaceae Tuberculose Flavonóides Tuberculosis Flavonoids |
topic |
Myrtaceae Tuberculose Flavonóides Tuberculosis Flavonoids |
description |
The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2011-11-28T19:43:32Z |
dc.date.available.fl_str_mv |
2021-09-30T19:55:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PAVAN, Fernando Rogério et al . Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae). Quím. Nova, São Paulo, v. 32, n. 5, 2009 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S0100-40422009000500026. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufms.br/handle/123456789/914 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S0100-40422009000500026 |
identifier_str_mv |
PAVAN, Fernando Rogério et al . Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae). Quím. Nova, São Paulo, v. 32, n. 5, 2009 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500026&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S0100-40422009000500026. |
url |
https://repositorio.ufms.br/handle/123456789/914 http://dx.doi.org/10.1590/S0100-40422009000500026 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Química Nova |
publisher.none.fl_str_mv |
Química Nova |
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reponame:Repositório Institucional da UFMS instname:Universidade Federal de Mato Grosso do Sul (UFMS) instacron:UFMS |
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Repositório Institucional da UFMS |
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