Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos

Detalhes bibliográficos
Autor(a) principal: Chaves,Douglas Siqueira de Almeida
Data de Publicação: 2010
Outros Autores: Costa,Sônia Soares, Almeida,Ana Paula de, Frattani,Flávia, Assafim,Mariane, Zingali,Russolina Benedeta
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100030
Resumo: Cardiovascular diseases are responsible for the largest number of deaths among humans worldwide, including heart attacks, strokes, and thrombosis. The treatment of thrombosis is generally through the administration of anticoagulant and/or antiplatelet drugs, which have some clinical limitations. Plants synthesize a wide variety of bioactive metabolites in response to different stimuli. This review focuses on a number of molecules of vegetal origin belonging to different chemical classes, with significant anticoagulant and antiplatelet effects. Their promising antithrombotic profile confirms the potential of natural products as a source of lead molecules for drug development in the prevention and treatment of thrombosis.
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spelling Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticosnatural anticoagulantnatural antiplateletcardiovascular diseasesCardiovascular diseases are responsible for the largest number of deaths among humans worldwide, including heart attacks, strokes, and thrombosis. The treatment of thrombosis is generally through the administration of anticoagulant and/or antiplatelet drugs, which have some clinical limitations. Plants synthesize a wide variety of bioactive metabolites in response to different stimuli. This review focuses on a number of molecules of vegetal origin belonging to different chemical classes, with significant anticoagulant and antiplatelet effects. Their promising antithrombotic profile confirms the potential of natural products as a source of lead molecules for drug development in the prevention and treatment of thrombosis.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100030Química Nova v.33 n.1 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000100030info:eu-repo/semantics/openAccessChaves,Douglas Siqueira de AlmeidaCosta,Sônia SoaresAlmeida,Ana Paula deFrattani,FláviaAssafim,MarianeZingali,Russolina Benedetapor2010-02-05T00:00:00Zoai:scielo:S0100-40422010000100030Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-02-05T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
title Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
spellingShingle Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
Chaves,Douglas Siqueira de Almeida
natural anticoagulant
natural antiplatelet
cardiovascular diseases
title_short Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
title_full Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
title_fullStr Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
title_full_unstemmed Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
title_sort Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos
author Chaves,Douglas Siqueira de Almeida
author_facet Chaves,Douglas Siqueira de Almeida
Costa,Sônia Soares
Almeida,Ana Paula de
Frattani,Flávia
Assafim,Mariane
Zingali,Russolina Benedeta
author_role author
author2 Costa,Sônia Soares
Almeida,Ana Paula de
Frattani,Flávia
Assafim,Mariane
Zingali,Russolina Benedeta
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Chaves,Douglas Siqueira de Almeida
Costa,Sônia Soares
Almeida,Ana Paula de
Frattani,Flávia
Assafim,Mariane
Zingali,Russolina Benedeta
dc.subject.por.fl_str_mv natural anticoagulant
natural antiplatelet
cardiovascular diseases
topic natural anticoagulant
natural antiplatelet
cardiovascular diseases
description Cardiovascular diseases are responsible for the largest number of deaths among humans worldwide, including heart attacks, strokes, and thrombosis. The treatment of thrombosis is generally through the administration of anticoagulant and/or antiplatelet drugs, which have some clinical limitations. Plants synthesize a wide variety of bioactive metabolites in response to different stimuli. This review focuses on a number of molecules of vegetal origin belonging to different chemical classes, with significant anticoagulant and antiplatelet effects. Their promising antithrombotic profile confirms the potential of natural products as a source of lead molecules for drug development in the prevention and treatment of thrombosis.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100030
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100030
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000100030
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.1 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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