PHYTOCHEMISTRY INVESTIGATION OF CASEARIA ARBOREA (RICH.) URB. (SALICACEAE) AND ANTIMICROBIAL ANALYSIS OF ITS DITERPENE

• Autor(a) principal: Leite-Ferreira,Maria D.
• Data de Publicação: 2018
• Outros Autores: Rocha-Souza,Maria S., Ramirez,Raphael R. de A., Chaves,Otemberg S., Teles,Yanna C. F., Pereira,Fillipe de O., Braz-Filho,Raimundo, Lima,Edeltrudes de O., Sarquis,Rosangela do Socorro F. R., Silva,Tânia Maria Sarmento da, Souza,Maria de Fátima Vanderlei de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Química Nova (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018000600619
• topic: Casearia arborea; Salicaceae; kolavelone; antimicrobial activity

A phytochemical investigation from aerial parts of Casearia arborea (Rich.) Urb. (Salicaceae) led to isolation and identification of: sitosterol, 4-en-stigmast-3-one, 13-hydroxy-trans-ent-cleroda-3,14-diene,3-hydroxy-2-oxo-trans-ent-cleroda-3,14-diene (kolavelone), a mixture of 13-hydroxy-trans-ent-cleroda-3,14-diene and an ester ethyl hexadecanoate, kaempferol-3-O-a-L-arabinofuranoside and 4',5,7-trihydroxy-3',5'-dimethoxyflavone (tricin). The compounds have been described for the first time in this species. Five trihydroxy-flavone-hexoside derivatives have been identified by LC-ESI-HR-MS. The antimicrobial activity of kolavelone was evaluated against strains of Staphylococcus, Bacillus, Pseudomonas, Shigella and Candida spores, and its minimum inhibitory concentration (MIC) was determined. The results showed the antimicrobial activity of kolavelone against several bacteria and Candida tropicalis indicating its potential use as antimicrobial agent.