Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions

Detalhes bibliográficos
Autor(a) principal: Fontana,Márcia Camponogara
Data de Publicação: 2010
Outros Autores: Hurtado,Felipe Kellermann, Wrasse,Micheli, Boligon,Aline Augusti, Venturini,Tarcieli Pozzebon, Rolim,Clarice Madalena Bueno, Beck,Ruy Carlos Ruver
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100035
Resumo: A reversed-phase liquid chromatographic (LC) and ultraviolet (UV) spectrophotometric methods were developed and validated for the assay of bromopride in oral and injectable solutions. The methods were validated according to ICH guideline. Both methods were linear in the range between 5-25 μg mL-1 (y = 41837x - 5103.4, r = 0.9996 and y = 0.0284x - 0.0351, r = 1, respectively). The statistical analysis showed no significant difference between the results obtained by the two methods. The proposed methods were found to be simple, rapid, precise, accurate, and sensitive. The LC and UV methods can be used in the routine quantitative analysis of bromopride in oral and injectable solutions.
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spelling Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutionsbromopridereversed-phase liquid chromatographyultraviolet spectrophotometryA reversed-phase liquid chromatographic (LC) and ultraviolet (UV) spectrophotometric methods were developed and validated for the assay of bromopride in oral and injectable solutions. The methods were validated according to ICH guideline. Both methods were linear in the range between 5-25 μg mL-1 (y = 41837x - 5103.4, r = 0.9996 and y = 0.0284x - 0.0351, r = 1, respectively). The statistical analysis showed no significant difference between the results obtained by the two methods. The proposed methods were found to be simple, rapid, precise, accurate, and sensitive. The LC and UV methods can be used in the routine quantitative analysis of bromopride in oral and injectable solutions.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100035Química Nova v.33 n.1 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000100035info:eu-repo/semantics/openAccessFontana,Márcia CamponogaraHurtado,Felipe KellermannWrasse,MicheliBoligon,Aline AugustiVenturini,Tarcieli PozzebonRolim,Clarice Madalena BuenoBeck,Ruy Carlos Ruvereng2010-02-05T00:00:00Zoai:scielo:S0100-40422010000100035Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-02-05T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
title Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
spellingShingle Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
Fontana,Márcia Camponogara
bromopride
reversed-phase liquid chromatography
ultraviolet spectrophotometry
title_short Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
title_full Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
title_fullStr Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
title_full_unstemmed Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
title_sort Development and validation of RP-LC and uv spectrophotometric methods to assay bromopride in oral and injectable solutions
author Fontana,Márcia Camponogara
author_facet Fontana,Márcia Camponogara
Hurtado,Felipe Kellermann
Wrasse,Micheli
Boligon,Aline Augusti
Venturini,Tarcieli Pozzebon
Rolim,Clarice Madalena Bueno
Beck,Ruy Carlos Ruver
author_role author
author2 Hurtado,Felipe Kellermann
Wrasse,Micheli
Boligon,Aline Augusti
Venturini,Tarcieli Pozzebon
Rolim,Clarice Madalena Bueno
Beck,Ruy Carlos Ruver
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fontana,Márcia Camponogara
Hurtado,Felipe Kellermann
Wrasse,Micheli
Boligon,Aline Augusti
Venturini,Tarcieli Pozzebon
Rolim,Clarice Madalena Bueno
Beck,Ruy Carlos Ruver
dc.subject.por.fl_str_mv bromopride
reversed-phase liquid chromatography
ultraviolet spectrophotometry
topic bromopride
reversed-phase liquid chromatography
ultraviolet spectrophotometry
description A reversed-phase liquid chromatographic (LC) and ultraviolet (UV) spectrophotometric methods were developed and validated for the assay of bromopride in oral and injectable solutions. The methods were validated according to ICH guideline. Both methods were linear in the range between 5-25 μg mL-1 (y = 41837x - 5103.4, r = 0.9996 and y = 0.0284x - 0.0351, r = 1, respectively). The statistical analysis showed no significant difference between the results obtained by the two methods. The proposed methods were found to be simple, rapid, precise, accurate, and sensitive. The LC and UV methods can be used in the routine quantitative analysis of bromopride in oral and injectable solutions.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100035
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000100035
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000100035
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.1 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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