Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Detalhes bibliográficos
Autor(a) principal: Arguelho,Maria Lara P. M.
Data de Publicação: 2010
Outros Autores: Alves,José do Patrocínio H., Stradiotto,Nelson R., Lacerda Júnior,Valdemar, Pires,José Maria, Beatriz,Adilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600014
Resumo: The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
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spelling Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formationamodiaquineguanineadductThe electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600014Química Nova v.33 n.6 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000600014info:eu-repo/semantics/openAccessArguelho,Maria Lara P. M.Alves,José do Patrocínio H.Stradiotto,Nelson R.Lacerda Júnior,ValdemarPires,José MariaBeatriz,Adilsoneng2010-08-24T00:00:00Zoai:scielo:S0100-40422010000600014Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-08-24T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
spellingShingle Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
Arguelho,Maria Lara P. M.
amodiaquine
guanine
adduct
title_short Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_full Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_fullStr Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_full_unstemmed Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_sort Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
author Arguelho,Maria Lara P. M.
author_facet Arguelho,Maria Lara P. M.
Alves,José do Patrocínio H.
Stradiotto,Nelson R.
Lacerda Júnior,Valdemar
Pires,José Maria
Beatriz,Adilson
author_role author
author2 Alves,José do Patrocínio H.
Stradiotto,Nelson R.
Lacerda Júnior,Valdemar
Pires,José Maria
Beatriz,Adilson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Arguelho,Maria Lara P. M.
Alves,José do Patrocínio H.
Stradiotto,Nelson R.
Lacerda Júnior,Valdemar
Pires,José Maria
Beatriz,Adilson
dc.subject.por.fl_str_mv amodiaquine
guanine
adduct
topic amodiaquine
guanine
adduct
description The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000600014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.6 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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