Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation

Detalhes bibliográficos
Autor(a) principal: Arguelho, Maria Lara Palmeira de Macedo
Data de Publicação: 2010
Outros Autores: Alves, José do Patrocínio Hora, Stradiotto, Nelson Ramos, Lacerda Júnior, Valdemar, Pires, José Maria, Beatriz, Adilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMS
DOI: http://dx.doi.org/10.1590/S0100-40422010000600014
Texto Completo: https://repositorio.ufms.br/handle/123456789/768
http://dx.doi.org/10.1590/S0100-40422010000600014
Resumo: The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
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spelling 2011-11-08T17:08:12Z2021-09-30T19:56:30Z2010ARGUELHO, Maria Lara P. M. et al . Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation. Quím. Nova, São Paulo, v. 33, n. 6, 2010 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600014&lng=pt&nrm=iso>. acessos em 08 nov. 2011. http://dx.doi.org/10.1590/S0100-40422010000600014.https://repositorio.ufms.br/handle/123456789/768http://dx.doi.org/10.1590/S0100-40422010000600014The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.engQuímica NovaAmodiaquinaGuaninaAdutos do DNAAmodiaquineGuanineDNA AdductsElectrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleArguelho, Maria Lara Palmeira de MacedoAlves, José do Patrocínio HoraStradiotto, Nelson RamosLacerda Júnior, ValdemarPires, José MariaBeatriz, Adilsoninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSTHUMBNAILEletrochemical and theorical evaluation.pdf.jpgEletrochemical and theorical evaluation.pdf.jpgGenerated Thumbnailimage/jpeg1542https://repositorio.ufms.br/bitstream/123456789/768/4/Eletrochemical%20and%20theorical%20evaluation.pdf.jpg8ea783bfc6e5ef700a704c7b7dffb875MD54ORIGINALEletrochemical and theorical evaluation.pdfEletrochemical and theorical evaluation.pdfapplication/pdf306025https://repositorio.ufms.br/bitstream/123456789/768/1/Eletrochemical%20and%20theorical%20evaluation.pdf4cecf157eb49deb9bf49062a5aa314efMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufms.br/bitstream/123456789/768/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTEletrochemical and theorical evaluation.pdf.txtEletrochemical and theorical evaluation.pdf.txtExtracted texttext/plain29665https://repositorio.ufms.br/bitstream/123456789/768/3/Eletrochemical%20and%20theorical%20evaluation.pdf.txt135cab2ec2b478b0c285f20b780bc58bMD53123456789/7682021-09-30 15:56:30.603oai:repositorio.ufms.br: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Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242021-09-30T19:56:30Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false
dc.title.pt_BR.fl_str_mv Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
title Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
spellingShingle Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
Arguelho, Maria Lara Palmeira de Macedo
Amodiaquina
Guanina
Adutos do DNA
Amodiaquine
Guanine
DNA Adducts
title_short Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
title_full Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
title_fullStr Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
title_full_unstemmed Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
title_sort Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
author Arguelho, Maria Lara Palmeira de Macedo
author_facet Arguelho, Maria Lara Palmeira de Macedo
Alves, José do Patrocínio Hora
Stradiotto, Nelson Ramos
Lacerda Júnior, Valdemar
Pires, José Maria
Beatriz, Adilson
author_role author
author2 Alves, José do Patrocínio Hora
Stradiotto, Nelson Ramos
Lacerda Júnior, Valdemar
Pires, José Maria
Beatriz, Adilson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Arguelho, Maria Lara Palmeira de Macedo
Alves, José do Patrocínio Hora
Stradiotto, Nelson Ramos
Lacerda Júnior, Valdemar
Pires, José Maria
Beatriz, Adilson
dc.subject.por.fl_str_mv Amodiaquina
Guanina
Adutos do DNA
Amodiaquine
Guanine
DNA Adducts
topic Amodiaquina
Guanina
Adutos do DNA
Amodiaquine
Guanine
DNA Adducts
description The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2011-11-08T17:08:12Z
dc.date.available.fl_str_mv 2021-09-30T19:56:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ARGUELHO, Maria Lara P. M. et al . Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation. Quím. Nova, São Paulo, v. 33, n. 6, 2010 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600014&lng=pt&nrm=iso>. acessos em 08 nov. 2011. http://dx.doi.org/10.1590/S0100-40422010000600014.
dc.identifier.uri.fl_str_mv https://repositorio.ufms.br/handle/123456789/768
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0100-40422010000600014
identifier_str_mv ARGUELHO, Maria Lara P. M. et al . Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation. Quím. Nova, São Paulo, v. 33, n. 6, 2010 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600014&lng=pt&nrm=iso>. acessos em 08 nov. 2011. http://dx.doi.org/10.1590/S0100-40422010000600014.
url https://repositorio.ufms.br/handle/123456789/768
http://dx.doi.org/10.1590/S0100-40422010000600014
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Química Nova
publisher.none.fl_str_mv Química Nova
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