Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Detalhes bibliográficos
Autor(a) principal: Arguelho, Maria Lara P. M.
Data de Publicação: 2010
Outros Autores: Alves, José do Patrocínio H., Stradiotto, Nelson Ramos [UNESP], Lacerda Júnior, Valdemar, Pires, José Maria, Beatriz, Adilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-40422010000600014
http://hdl.handle.net/11449/27620
Resumo: The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
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spelling Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formationamodiaquineguanineadductThe electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de Sergipe Departamento de QuímicaUniversidade Estadual Paulista Instituto de QuímicaUniversidade Federal do Espírito Santo (UFES) Departamento de QuímicaUniversidade Federal de Mato Grosso do Sul Departamento de QuímicaUniversidade Estadual Paulista Instituto de QuímicaSociedade Brasileira de QuímicaUniversidade Federal de Sergipe (UFS)Universidade Estadual Paulista (Unesp)Universidade Federal do Espírito Santo (UFES)Universidade Federal de Mato Grosso do Sul (UFMS)Arguelho, Maria Lara P. M.Alves, José do Patrocínio H.Stradiotto, Nelson Ramos [UNESP]Lacerda Júnior, ValdemarPires, José MariaBeatriz, Adilson2014-05-20T15:10:25Z2014-05-20T15:10:25Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1291-1296application/pdfhttp://dx.doi.org/10.1590/S0100-40422010000600014Química Nova. Sociedade Brasileira de Química, v. 33, n. 6, p. 1291-1296, 2010.0100-4042http://hdl.handle.net/11449/2762010.1590/S0100-40422010000600014S0100-40422010000600014WOS:000281692900014S0100-40422010000600014.pdf0072173018005712SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2023-12-11T06:17:53Zoai:repositorio.unesp.br:11449/27620Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:03:53.633234Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
spellingShingle Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
Arguelho, Maria Lara P. M.
amodiaquine
guanine
adduct
title_short Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_full Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_fullStr Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_full_unstemmed Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
title_sort Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
author Arguelho, Maria Lara P. M.
author_facet Arguelho, Maria Lara P. M.
Alves, José do Patrocínio H.
Stradiotto, Nelson Ramos [UNESP]
Lacerda Júnior, Valdemar
Pires, José Maria
Beatriz, Adilson
author_role author
author2 Alves, José do Patrocínio H.
Stradiotto, Nelson Ramos [UNESP]
Lacerda Júnior, Valdemar
Pires, José Maria
Beatriz, Adilson
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Sergipe (UFS)
Universidade Estadual Paulista (Unesp)
Universidade Federal do Espírito Santo (UFES)
Universidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.author.fl_str_mv Arguelho, Maria Lara P. M.
Alves, José do Patrocínio H.
Stradiotto, Nelson Ramos [UNESP]
Lacerda Júnior, Valdemar
Pires, José Maria
Beatriz, Adilson
dc.subject.por.fl_str_mv amodiaquine
guanine
adduct
topic amodiaquine
guanine
adduct
description The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2014-05-20T15:10:25Z
2014-05-20T15:10:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422010000600014
Química Nova. Sociedade Brasileira de Química, v. 33, n. 6, p. 1291-1296, 2010.
0100-4042
http://hdl.handle.net/11449/27620
10.1590/S0100-40422010000600014
S0100-40422010000600014
WOS:000281692900014
S0100-40422010000600014.pdf
0072173018005712
url http://dx.doi.org/10.1590/S0100-40422010000600014
http://hdl.handle.net/11449/27620
identifier_str_mv Química Nova. Sociedade Brasileira de Química, v. 33, n. 6, p. 1291-1296, 2010.
0100-4042
10.1590/S0100-40422010000600014
S0100-40422010000600014
WOS:000281692900014
S0100-40422010000600014.pdf
0072173018005712
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Química Nova
0.646
0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1291-1296
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129156209180672

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