Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets

Detalhes bibliográficos
Autor(a) principal: Friedrich,Rossana Barcellos
Data de Publicação: 2009
Outros Autores: Ravanello,Aline, Cichota,Luiz Carlos, Rolim,Clarice Madalena Bueno, Beck,Ruy Carlos Ruver
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400038
Resumo: This work reports the validation of an analytical UV spectrophotometric method to assay dexamethasone in tablets (assay and dissolution studies). The method was linear in the range between 1 and 30 µg mL-1 presenting a good correlation coefficient (r = 0.9998, n = 7). Precision and accuracy analysis showed low relative standard deviation (< 2.00%) and good percentual recoveries (95-105%). The procedure was linear, accurate, precise, and robust. The method is simple, and it has low cost. It does not use polluting reagents and can be applied in dissolution studies, being an adequate alternative to assay dexamethasone in tablets.
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spelling Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tabletsdexamethasonetabletsUV spectrophotometryThis work reports the validation of an analytical UV spectrophotometric method to assay dexamethasone in tablets (assay and dissolution studies). The method was linear in the range between 1 and 30 µg mL-1 presenting a good correlation coefficient (r = 0.9998, n = 7). Precision and accuracy analysis showed low relative standard deviation (< 2.00%) and good percentual recoveries (95-105%). The procedure was linear, accurate, precise, and robust. The method is simple, and it has low cost. It does not use polluting reagents and can be applied in dissolution studies, being an adequate alternative to assay dexamethasone in tablets.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400038Química Nova v.32 n.4 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000400038info:eu-repo/semantics/openAccessFriedrich,Rossana BarcellosRavanello,AlineCichota,Luiz CarlosRolim,Clarice Madalena BuenoBeck,Ruy Carlos Ruvereng2009-06-22T00:00:00Zoai:scielo:S0100-40422009000400038Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-06-22T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
title Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
spellingShingle Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
Friedrich,Rossana Barcellos
dexamethasone
tablets
UV spectrophotometry
title_short Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
title_full Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
title_fullStr Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
title_full_unstemmed Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
title_sort Validation of a simple and rapid UV spectrophotometric method for dexamethasone assay in tablets
author Friedrich,Rossana Barcellos
author_facet Friedrich,Rossana Barcellos
Ravanello,Aline
Cichota,Luiz Carlos
Rolim,Clarice Madalena Bueno
Beck,Ruy Carlos Ruver
author_role author
author2 Ravanello,Aline
Cichota,Luiz Carlos
Rolim,Clarice Madalena Bueno
Beck,Ruy Carlos Ruver
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Friedrich,Rossana Barcellos
Ravanello,Aline
Cichota,Luiz Carlos
Rolim,Clarice Madalena Bueno
Beck,Ruy Carlos Ruver
dc.subject.por.fl_str_mv dexamethasone
tablets
UV spectrophotometry
topic dexamethasone
tablets
UV spectrophotometry
description This work reports the validation of an analytical UV spectrophotometric method to assay dexamethasone in tablets (assay and dissolution studies). The method was linear in the range between 1 and 30 µg mL-1 presenting a good correlation coefficient (r = 0.9998, n = 7). Precision and accuracy analysis showed low relative standard deviation (< 2.00%) and good percentual recoveries (95-105%). The procedure was linear, accurate, precise, and robust. The method is simple, and it has low cost. It does not use polluting reagents and can be applied in dissolution studies, being an adequate alternative to assay dexamethasone in tablets.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400038
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400038
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000400038
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.4 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318109118431232

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