Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment

Detalhes bibliográficos
Autor(a) principal: Nolasco,Daniela Magalhães
Data de Publicação: 2007
Outros Autores: Gusmão,Andréia, Siqueira,Maria Elisa Pereira Bastos de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000400009
Resumo: The aim of the present study was to determine 2,5-hexanedione (2,5-HD), a metabolite of n-hexane, by gas chromatography/flame ionization detection in 31 workers exposed to n-hexane after two types of sample pretreatment, i.e., with (total 2,5-HD) and without (free 2,5-HD) acid hydrolysis. The mean urinary 2,5-HD was 0.52 mg/L (free) and 2.88 mg/L (total), this difference being significant (Student t-test, p < 0.05). The differences in the results according to the sample treatment support the need to modify the current Brazilian legislation, which proposes the analysis of 2,5-HD without indicating whether it is the free or total metabolite.
id SBQ-3_eadb1c1805707ef94fa19321e1c1b4c2
oai_identifier_str oai:scielo:S0100-40422007000400009
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment2,5-hexanedionebiomonitoringsample pretreatmentThe aim of the present study was to determine 2,5-hexanedione (2,5-HD), a metabolite of n-hexane, by gas chromatography/flame ionization detection in 31 workers exposed to n-hexane after two types of sample pretreatment, i.e., with (total 2,5-HD) and without (free 2,5-HD) acid hydrolysis. The mean urinary 2,5-HD was 0.52 mg/L (free) and 2.88 mg/L (total), this difference being significant (Student t-test, p < 0.05). The differences in the results according to the sample treatment support the need to modify the current Brazilian legislation, which proposes the analysis of 2,5-HD without indicating whether it is the free or total metabolite.Sociedade Brasileira de Química2007-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000400009Química Nova v.30 n.4 2007reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422007000400009info:eu-repo/semantics/openAccessNolasco,Daniela MagalhãesGusmão,AndréiaSiqueira,Maria Elisa Pereira Bastos deeng2007-08-10T00:00:00Zoai:scielo:S0100-40422007000400009Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2007-08-10T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
title Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
spellingShingle Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
Nolasco,Daniela Magalhães
2,5-hexanedione
biomonitoring
sample pretreatment
title_short Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
title_full Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
title_fullStr Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
title_full_unstemmed Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
title_sort Urinary 2,5-hexanedione in workers exposed to n-hexane: influence of the sample treatment
author Nolasco,Daniela Magalhães
author_facet Nolasco,Daniela Magalhães
Gusmão,Andréia
Siqueira,Maria Elisa Pereira Bastos de
author_role author
author2 Gusmão,Andréia
Siqueira,Maria Elisa Pereira Bastos de
author2_role author
author
dc.contributor.author.fl_str_mv Nolasco,Daniela Magalhães
Gusmão,Andréia
Siqueira,Maria Elisa Pereira Bastos de
dc.subject.por.fl_str_mv 2,5-hexanedione
biomonitoring
sample pretreatment
topic 2,5-hexanedione
biomonitoring
sample pretreatment
description The aim of the present study was to determine 2,5-hexanedione (2,5-HD), a metabolite of n-hexane, by gas chromatography/flame ionization detection in 31 workers exposed to n-hexane after two types of sample pretreatment, i.e., with (total 2,5-HD) and without (free 2,5-HD) acid hydrolysis. The mean urinary 2,5-HD was 0.52 mg/L (free) and 2.88 mg/L (total), this difference being significant (Student t-test, p < 0.05). The differences in the results according to the sample treatment support the need to modify the current Brazilian legislation, which proposes the analysis of 2,5-HD without indicating whether it is the free or total metabolite.
publishDate 2007
dc.date.none.fl_str_mv 2007-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000400009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000400009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422007000400009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.30 n.4 2007
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318106437222400

Registros relacionados