Action mechanisms of the oral microbiota in the development of cancer. Scoping Review.
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | preprint |
Idioma: | spa |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/3219 |
Resumo: | In this Scoping Review, we present the evidence recorded in the literature about that oral microbiota can generate a carcinogenic action, acting through three main mechanisms: on the extracellular space, activating intracellular signaling pathways and/or generating direct action on DNA, and that the principal pathogens studied are Fusobacterium Nucleatum and Porphyromona Gingivalis. Nowadays, there is sufficient evidence about the association between oral microbiota and several types of cancer, however, there is not much knowledge about the mechanisms by which this microbiota participates in its development. We present a compilation of different mechanisms of action used by oral cavity bacteria in the process of carcinogenesis in four different types of cancer. It is of great importance to increase the knowledge about the etiological role of the oral microbiota in the development of cancer disease because it would be established as a new carcinogenic agent and its knowledge could be used as a valuable tool in the detection and treatment of this disease. |
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Action mechanisms of the oral microbiota in the development of cancer. Scoping Review.Mecanismos de acción de la microbiota oral en el desarrollo del cáncer. Revisión sistemática exploratoria.CarcinogénesisBacteriaBocaMicrobiotaNeoplasiasCarcinogenesis BacteriaMouthNeoplasmMicrobiotaIn this Scoping Review, we present the evidence recorded in the literature about that oral microbiota can generate a carcinogenic action, acting through three main mechanisms: on the extracellular space, activating intracellular signaling pathways and/or generating direct action on DNA, and that the principal pathogens studied are Fusobacterium Nucleatum and Porphyromona Gingivalis. Nowadays, there is sufficient evidence about the association between oral microbiota and several types of cancer, however, there is not much knowledge about the mechanisms by which this microbiota participates in its development. We present a compilation of different mechanisms of action used by oral cavity bacteria in the process of carcinogenesis in four different types of cancer. It is of great importance to increase the knowledge about the etiological role of the oral microbiota in the development of cancer disease because it would be established as a new carcinogenic agent and its knowledge could be used as a valuable tool in the detection and treatment of this disease. En esta revisión sistemática exploratoria, presentamos la evidencia registrada en la literatura, de que la microbiota oral puede generar una acción carcinogénica, actuando a través de tres mecanismos principales: sobre el medio extracelular, activando vías de señalización intracelular y / o generando acción directa sobre el ADN, y que las principales bacterias estudiadas corresponden a Fusobacterium Nucleatum y Porphyromona Gingivalis. En la actualidad hay evidencia suficiente acerca de la asociación entre microbiota oral y distintos tipos de cáncer, sin embargo, no hay gran conocimiento de los mecanismos por los cuales esta microbiota participa en su desarrollo. Presentamos una recopilación de los diversos mecanismos de acción que utilizan las bacterias de la cavidad oral en el proceso de carcinogénesis en cuatro tipos diferentes de cáncer.SciELO PreprintsSciELO PreprintsSciELO Preprints2021-11-17info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/321910.1590/SciELOPreprints.3219spahttps://preprints.scielo.org/index.php/scielo/article/view/3219/5775Copyright (c) 2021 Consuelo López Matamala, Florencia Romero, Marcelo Sánchezhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLópez Matamala, ConsueloRomero, FlorenciaSánchez, Marceloreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2021-11-16T18:40:37Zoai:ops.preprints.scielo.org:preprint/3219Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2021-11-16T18:40:37SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. Mecanismos de acción de la microbiota oral en el desarrollo del cáncer. Revisión sistemática exploratoria. |
title |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. |
spellingShingle |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. López Matamala, Consuelo Carcinogénesis Bacteria Boca Microbiota Neoplasias Carcinogenesis Bacteria Mouth Neoplasm Microbiota |
title_short |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. |
title_full |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. |
title_fullStr |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. |
title_full_unstemmed |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. |
title_sort |
Action mechanisms of the oral microbiota in the development of cancer. Scoping Review. |
author |
López Matamala, Consuelo |
author_facet |
López Matamala, Consuelo Romero, Florencia Sánchez, Marcelo |
author_role |
author |
author2 |
Romero, Florencia Sánchez, Marcelo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
López Matamala, Consuelo Romero, Florencia Sánchez, Marcelo |
dc.subject.por.fl_str_mv |
Carcinogénesis Bacteria Boca Microbiota Neoplasias Carcinogenesis Bacteria Mouth Neoplasm Microbiota |
topic |
Carcinogénesis Bacteria Boca Microbiota Neoplasias Carcinogenesis Bacteria Mouth Neoplasm Microbiota |
description |
In this Scoping Review, we present the evidence recorded in the literature about that oral microbiota can generate a carcinogenic action, acting through three main mechanisms: on the extracellular space, activating intracellular signaling pathways and/or generating direct action on DNA, and that the principal pathogens studied are Fusobacterium Nucleatum and Porphyromona Gingivalis. Nowadays, there is sufficient evidence about the association between oral microbiota and several types of cancer, however, there is not much knowledge about the mechanisms by which this microbiota participates in its development. We present a compilation of different mechanisms of action used by oral cavity bacteria in the process of carcinogenesis in four different types of cancer. It is of great importance to increase the knowledge about the etiological role of the oral microbiota in the development of cancer disease because it would be established as a new carcinogenic agent and its knowledge could be used as a valuable tool in the detection and treatment of this disease. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
format |
preprint |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/3219 10.1590/SciELOPreprints.3219 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/3219 |
identifier_str_mv |
10.1590/SciELOPreprints.3219 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/article/view/3219/5775 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Consuelo López Matamala, Florencia Romero, Marcelo Sánchez https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Consuelo López Matamala, Florencia Romero, Marcelo Sánchez https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO Preprints SciELO Preprints SciELO Preprints |
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reponame:SciELO Preprints instname:SciELO instacron:SCI |
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SciELO |
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SCI |
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SCI |
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SciELO Preprints |
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SciELO Preprints |
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SciELO Preprints - SciELO |
repository.mail.fl_str_mv |
scielo.submission@scielo.org |
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