THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | preprint |
Idioma: | eng |
Título da fonte: | SciELO Preprints |
Texto Completo: | https://preprints.scielo.org/index.php/scielo/preprint/view/866 |
Resumo: | Many well-known commercial pharmaceuticals have been used in the therapy against SARS-CoV-2, although in a random and experimental way, since this use is only based on the knowledge about culture cells in vitro. But, it is widely known that it is not correlated with assays in vivo conducted with in animals or with clinical trials in humans. Knowledge about treatments applied to previous pandemic infections caused by viruses such as MERS and SARS may be the most interesting strategy used to screen products with potential to act against SARS-CoV-2. Mechanistic aspects of virus infections and antiviral action mechanisms were herein analyzed based on the assumption that these commercial pharmaceuticals can eliminate the virus. Perspectives about these procedures, as well as about finished clinical trials and the ones yet in progress, were also addressed in the current study. |
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THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVESLOS FARMACÉUTICOS ANTIVIRALES MÁS PROMINENTES UTILIZADOS CONTRA COVID-19 Y SUS PERSPECTIVASOS MEDICAMENTOS ANTIVIRAIS MAIS PROMINENTES USADOS CONTRA COVID-19 E SUAS PERSPECTIVASCOVID-19TratamentoMecanismo de AçãoSARS-CoV-2COVID-19TreatmentMechanism of actionSARS-CoV-2COVID-19Tratamientomecanismo de acciónSARS-CoV-2Many well-known commercial pharmaceuticals have been used in the therapy against SARS-CoV-2, although in a random and experimental way, since this use is only based on the knowledge about culture cells in vitro. But, it is widely known that it is not correlated with assays in vivo conducted with in animals or with clinical trials in humans. Knowledge about treatments applied to previous pandemic infections caused by viruses such as MERS and SARS may be the most interesting strategy used to screen products with potential to act against SARS-CoV-2. Mechanistic aspects of virus infections and antiviral action mechanisms were herein analyzed based on the assumption that these commercial pharmaceuticals can eliminate the virus. Perspectives about these procedures, as well as about finished clinical trials and the ones yet in progress, were also addressed in the current study.Muchos productos farmacéuticos comerciales bien conocidos se han utilizado en la terapia contra el SARS-CoV-2, aunque de manera aleatoria y experimental, ya que este uso solo se basa en el conocimiento sobre células de cultivo in vitro. Pero, es ampliamente conocido que no está correlacionado con ensayos in vivo realizados con animales o con ensayos clínicos en humanos. El conocimiento sobre los tratamientos aplicados a infecciones pandémicas previas causadas por virus como MERS y SARS puede ser la estrategia más interesante utilizada para detectar productos con potencial para actuar contra el SARS-CoV-2. Los aspectos mecanicistas de las infecciones por virus y los mecanismos de acción antivirales se analizaron en este documento basándose en el supuesto de que estos productos farmacéuticos comerciales pueden eliminar el virus. Las perspectivas sobre estos procedimientos, así como sobre los ensayos clínicos terminados y los que aún están en progreso, también se abordaron en el estudio actual.Muitos fármacos comerciais bem conhecidos têm sido utilizados na terapia contra SARS-CoV-2, embora de maneira aleatória e experimental, uma vez que esse uso é baseado apenas no conhecimento sobre cultura de células in vitro. Entretanto, sabe-se o que não está correlacionado com ensaios in vivo realizados com animais ou com ensaios clínicos em humanos. O conhecimento sobre tratamentos aplicados a infecções pandêmicas anteriores causadas por vírus como MERS e SARS pode ser a estratégia mais interessante usada para rastrear produtos com potencial para agir contra o SARS-CoV-2. Aspectos mecanísticos de infecções por vírus e mecanismos de ação antiviral foram aqui analisados com base no pressuposto de que esses produtos farmacêuticos comerciais podem eliminar o vírus. As perspectivas sobre esses procedimentos, bem como sobre os ensaios clínicos concluídos e os que ainda estão em andamento, também foram abordados no presente estudo.SciELO PreprintsSciELO PreprintsSciELO Preprints2020-06-30info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/86610.1590/SciELOPreprints.866enghttps://preprints.scielo.org/index.php/scielo/article/view/866/1201Copyright (c) 2020 Wagner Fávaro, Nelson Duránhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFávaro, WagnerDurán, Nelsonreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2020-06-28T23:43:55Zoai:ops.preprints.scielo.org:preprint/866Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2020-06-28T23:43:55SciELO Preprints - SciELOfalse |
dc.title.none.fl_str_mv |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES LOS FARMACÉUTICOS ANTIVIRALES MÁS PROMINENTES UTILIZADOS CONTRA COVID-19 Y SUS PERSPECTIVAS OS MEDICAMENTOS ANTIVIRAIS MAIS PROMINENTES USADOS CONTRA COVID-19 E SUAS PERSPECTIVAS |
title |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES |
spellingShingle |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES Fávaro, Wagner COVID-19 Tratamento Mecanismo de Ação SARS-CoV-2 COVID-19 Treatment Mechanism of action SARS-CoV-2 COVID-19 Tratamiento mecanismo de acción SARS-CoV-2 |
title_short |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES |
title_full |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES |
title_fullStr |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES |
title_full_unstemmed |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES |
title_sort |
THE MOST PROMINENT ANTIVIRAL PHARMACEUTICALS USED AGAINST COVID-19 AND THEIR PERSPECTIVES |
author |
Fávaro, Wagner |
author_facet |
Fávaro, Wagner Durán, Nelson |
author_role |
author |
author2 |
Durán, Nelson |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Fávaro, Wagner Durán, Nelson |
dc.subject.por.fl_str_mv |
COVID-19 Tratamento Mecanismo de Ação SARS-CoV-2 COVID-19 Treatment Mechanism of action SARS-CoV-2 COVID-19 Tratamiento mecanismo de acción SARS-CoV-2 |
topic |
COVID-19 Tratamento Mecanismo de Ação SARS-CoV-2 COVID-19 Treatment Mechanism of action SARS-CoV-2 COVID-19 Tratamiento mecanismo de acción SARS-CoV-2 |
description |
Many well-known commercial pharmaceuticals have been used in the therapy against SARS-CoV-2, although in a random and experimental way, since this use is only based on the knowledge about culture cells in vitro. But, it is widely known that it is not correlated with assays in vivo conducted with in animals or with clinical trials in humans. Knowledge about treatments applied to previous pandemic infections caused by viruses such as MERS and SARS may be the most interesting strategy used to screen products with potential to act against SARS-CoV-2. Mechanistic aspects of virus infections and antiviral action mechanisms were herein analyzed based on the assumption that these commercial pharmaceuticals can eliminate the virus. Perspectives about these procedures, as well as about finished clinical trials and the ones yet in progress, were also addressed in the current study. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/preprint info:eu-repo/semantics/publishedVersion |
format |
preprint |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/preprint/view/866 10.1590/SciELOPreprints.866 |
url |
https://preprints.scielo.org/index.php/scielo/preprint/view/866 |
identifier_str_mv |
10.1590/SciELOPreprints.866 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://preprints.scielo.org/index.php/scielo/article/view/866/1201 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Wagner Fávaro, Nelson Durán https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Wagner Fávaro, Nelson Durán https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
publisher.none.fl_str_mv |
SciELO Preprints SciELO Preprints SciELO Preprints |
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SciELO |
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SCI |
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SCI |
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SciELO Preprints |
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SciELO Preprints |
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SciELO Preprints - SciELO |
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