Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice

Detalhes bibliográficos
Autor(a) principal: Chaves, Ian
Data de Publicação: 2022
Outros Autores: Zicker, Marina Campos, Laranjeira, Alice de Oliveira, Silveira, Ana Letícia Malheiros, Aguiar, Daniele Cristina de, Barrioni, Breno Rocha, Ferreira, Adaliene Versiani de Matos, Teixeira, Mauro Martins, Silva, Tarcília Aparecida da, Souza, Daniele da Glória de, Madeira, Mila Fernandes Moreira
Tipo de documento: Conjunto de dados
Título da fonte: SciELO Data
Texto Completo: https://doi.org/10.48331/scielodata.OIBYC1
Resumo: The current study aimed to relate obesity, changes in oral microbiota, and induction of alveolar bone loss, as seen in PD. Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, the alveolar bone loss was evaluated by microCT, and the microbiota composition of mice fed or not with the HF diet was assessed by DNA-DNA hybridization technique. Topical application of chlorhexidine (CHX) was used to investigate the impact of the oral microbiota on the alveolar bone loss associated with obesity.
id SCI-2_6952f50ef95927581bf2fe7ebd0cbf37
oai_identifier_str doi:10.48331/scielodata.OIBYC1
network_acronym_str SCI-2
network_name_str SciELO Data
repository_id_str
spelling https://doi.org/10.48331/scielodata.OIBYC1Chaves, IanZicker, Marina CamposLaranjeira, Alice de OliveiraSilveira, Ana Letícia MalheirosAguiar, Daniele Cristina deBarrioni, Breno RochaFerreira, Adaliene Versiani de MatosTeixeira, Mauro MartinsSilva, Tarcília Aparecida daSouza, Daniele da Glória deMadeira, Mila Fernandes MoreiraDysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in miceSciELO DataThe current study aimed to relate obesity, changes in oral microbiota, and induction of alveolar bone loss, as seen in PD. Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, the alveolar bone loss was evaluated by microCT, and the microbiota composition of mice fed or not with the HF diet was assessed by DNA-DNA hybridization technique. Topical application of chlorhexidine (CHX) was used to investigate the impact of the oral microbiota on the alveolar bone loss associated with obesity.2022-11-04info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0Medicine, Health and Life SciencesPeriodontal diseasesObesityAlveolar bone lossOral microbiotainfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/publishedVersionDatasetreponame:SciELO Datainstname:Scientific Electronic Library Online (SCIELO)instacron:SCIRepositório de Dados de PesquisaONGhttps://data.scielo.org/oai/requestdata@scielo.orgopendoar:2024-04-11T06:11:39SciELO Data - Scientific Electronic Library Online (SCIELO)falsedoi:10.48331/scielodata.OIBYC1
dc.title.none.fl_str_mv Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
title Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
spellingShingle Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
Chaves, Ian
Medicine, Health and Life Sciences
Periodontal diseases
Obesity
Alveolar bone loss
Oral microbiota
title_short Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
title_full Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
title_fullStr Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
title_full_unstemmed Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
title_sort Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
author Chaves, Ian
author_facet Chaves, Ian
Zicker, Marina Campos
Laranjeira, Alice de Oliveira
Silveira, Ana Letícia Malheiros
Aguiar, Daniele Cristina de
Barrioni, Breno Rocha
Ferreira, Adaliene Versiani de Matos
Teixeira, Mauro Martins
Silva, Tarcília Aparecida da
Souza, Daniele da Glória de
Madeira, Mila Fernandes Moreira
author_role author
author2 Zicker, Marina Campos
Laranjeira, Alice de Oliveira
Silveira, Ana Letícia Malheiros
Aguiar, Daniele Cristina de
Barrioni, Breno Rocha
Ferreira, Adaliene Versiani de Matos
Teixeira, Mauro Martins
Silva, Tarcília Aparecida da
Souza, Daniele da Glória de
Madeira, Mila Fernandes Moreira
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chaves, Ian
Zicker, Marina Campos
Laranjeira, Alice de Oliveira
Silveira, Ana Letícia Malheiros
Aguiar, Daniele Cristina de
Barrioni, Breno Rocha
Ferreira, Adaliene Versiani de Matos
Teixeira, Mauro Martins
Silva, Tarcília Aparecida da
Souza, Daniele da Glória de
Madeira, Mila Fernandes Moreira
dc.subject.none.fl_str_mv Medicine, Health and Life Sciences
Periodontal diseases
Obesity
Alveolar bone loss
Oral microbiota
topic Medicine, Health and Life Sciences
Periodontal diseases
Obesity
Alveolar bone loss
Oral microbiota
description The current study aimed to relate obesity, changes in oral microbiota, and induction of alveolar bone loss, as seen in PD. Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, the alveolar bone loss was evaluated by microCT, and the microbiota composition of mice fed or not with the HF diet was assessed by DNA-DNA hybridization technique. Topical application of chlorhexidine (CHX) was used to investigate the impact of the oral microbiota on the alveolar bone loss associated with obesity.
publishDate 2022
dc.date.issued.fl_str_mv 2022-11-04
dc.type.openaire.fl_str_mv info:eu-repo/semantics/dataset
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/dataset
format dataset
status_str publishedVersion
dc.identifier.url.fl_str_mv https://doi.org/10.48331/scielodata.OIBYC1
url https://doi.org/10.48331/scielodata.OIBYC1
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
dc.format.none.fl_str_mv Dataset
dc.publisher.none.fl_str_mv SciELO Data
publisher.none.fl_str_mv SciELO Data
dc.source.none.fl_str_mv reponame:SciELO Data
instname:Scientific Electronic Library Online (SCIELO)
instacron:SCI
instname_str Scientific Electronic Library Online (SCIELO)
instacron_str SCI
institution SCI
reponame_str SciELO Data
collection SciELO Data
repository.name.fl_str_mv SciELO Data - Scientific Electronic Library Online (SCIELO)
repository.mail.fl_str_mv data@scielo.org
_version_ 1797042024101183488

Registros relacionados