Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Conjunto de dados |
Título da fonte: | SciELO Data |
Texto Completo: | https://doi.org/10.48331/scielodata.OIBYC1 |
Resumo: | The current study aimed to relate obesity, changes in oral microbiota, and induction of alveolar bone loss, as seen in PD. Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, the alveolar bone loss was evaluated by microCT, and the microbiota composition of mice fed or not with the HF diet was assessed by DNA-DNA hybridization technique. Topical application of chlorhexidine (CHX) was used to investigate the impact of the oral microbiota on the alveolar bone loss associated with obesity. |
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https://doi.org/10.48331/scielodata.OIBYC1Chaves, IanZicker, Marina CamposLaranjeira, Alice de OliveiraSilveira, Ana Letícia MalheirosAguiar, Daniele Cristina deBarrioni, Breno RochaFerreira, Adaliene Versiani de MatosTeixeira, Mauro MartinsSilva, Tarcília Aparecida daSouza, Daniele da Glória deMadeira, Mila Fernandes MoreiraDysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in miceSciELO DataThe current study aimed to relate obesity, changes in oral microbiota, and induction of alveolar bone loss, as seen in PD. Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, the alveolar bone loss was evaluated by microCT, and the microbiota composition of mice fed or not with the HF diet was assessed by DNA-DNA hybridization technique. Topical application of chlorhexidine (CHX) was used to investigate the impact of the oral microbiota on the alveolar bone loss associated with obesity.2022-11-04info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0Medicine, Health and Life SciencesPeriodontal diseasesObesityAlveolar bone lossOral microbiotainfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/publishedVersionDatasetreponame:SciELO Datainstname:Scientific Electronic Library Online (SCIELO)instacron:SCIRepositório de Dados de PesquisaONGhttps://data.scielo.org/oai/requestdata@scielo.orgopendoar:2024-04-11T06:11:39SciELO Data - Scientific Electronic Library Online (SCIELO)falsedoi:10.48331/scielodata.OIBYC1 |
dc.title.none.fl_str_mv |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice |
title |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice |
spellingShingle |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice Chaves, Ian Medicine, Health and Life Sciences Periodontal diseases Obesity Alveolar bone loss Oral microbiota |
title_short |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice |
title_full |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice |
title_fullStr |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice |
title_full_unstemmed |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice |
title_sort |
Dysbiotic oral microbiota contributes to alveolar bone loss associated with obesity in mice |
author |
Chaves, Ian |
author_facet |
Chaves, Ian Zicker, Marina Campos Laranjeira, Alice de Oliveira Silveira, Ana Letícia Malheiros Aguiar, Daniele Cristina de Barrioni, Breno Rocha Ferreira, Adaliene Versiani de Matos Teixeira, Mauro Martins Silva, Tarcília Aparecida da Souza, Daniele da Glória de Madeira, Mila Fernandes Moreira |
author_role |
author |
author2 |
Zicker, Marina Campos Laranjeira, Alice de Oliveira Silveira, Ana Letícia Malheiros Aguiar, Daniele Cristina de Barrioni, Breno Rocha Ferreira, Adaliene Versiani de Matos Teixeira, Mauro Martins Silva, Tarcília Aparecida da Souza, Daniele da Glória de Madeira, Mila Fernandes Moreira |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Chaves, Ian Zicker, Marina Campos Laranjeira, Alice de Oliveira Silveira, Ana Letícia Malheiros Aguiar, Daniele Cristina de Barrioni, Breno Rocha Ferreira, Adaliene Versiani de Matos Teixeira, Mauro Martins Silva, Tarcília Aparecida da Souza, Daniele da Glória de Madeira, Mila Fernandes Moreira |
dc.subject.none.fl_str_mv |
Medicine, Health and Life Sciences Periodontal diseases Obesity Alveolar bone loss Oral microbiota |
topic |
Medicine, Health and Life Sciences Periodontal diseases Obesity Alveolar bone loss Oral microbiota |
description |
The current study aimed to relate obesity, changes in oral microbiota, and induction of alveolar bone loss, as seen in PD. Two obesity mice models were performed, one using 12 weeks of the dietary protocol with a high-fat (HF) diet in C57BL/6 mice and the other using leptin receptor-deficient mice (db/db-/-), which became spontaneously obese. After euthanasia, the alveolar bone loss was evaluated by microCT, and the microbiota composition of mice fed or not with the HF diet was assessed by DNA-DNA hybridization technique. Topical application of chlorhexidine (CHX) was used to investigate the impact of the oral microbiota on the alveolar bone loss associated with obesity. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022-11-04 |
dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/dataset |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/dataset |
format |
dataset |
status_str |
publishedVersion |
dc.identifier.url.fl_str_mv |
https://doi.org/10.48331/scielodata.OIBYC1 |
url |
https://doi.org/10.48331/scielodata.OIBYC1 |
dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
dc.format.none.fl_str_mv |
Dataset |
dc.publisher.none.fl_str_mv |
SciELO Data |
publisher.none.fl_str_mv |
SciELO Data |
dc.source.none.fl_str_mv |
reponame:SciELO Data instname:Scientific Electronic Library Online (SCIELO) instacron:SCI |
instname_str |
Scientific Electronic Library Online (SCIELO) |
instacron_str |
SCI |
institution |
SCI |
reponame_str |
SciELO Data |
collection |
SciELO Data |
repository.name.fl_str_mv |
SciELO Data - Scientific Electronic Library Online (SCIELO) |
repository.mail.fl_str_mv |
data@scielo.org |
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1797042024101183488 |