Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line
Main Author: | |
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Publication Date: | 2021 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Brazilian Archives of Biology and Technology |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132021000100428 |
Summary: | Abstract Rhus coriaria, popularly known as sumac, has been used as a spice powder in the Middle East for centuries. It contains a broad range of naturally occurring compounds such as flavonoids, proteins, anthocyanins and volatile oils. It showed a putative importance in treatment of different disorders including cancers. In the current study, R. coriaria fruit extract was used for green synthesis of silver nanostructures (Ag-NSs) and their anticancer activity was tested against human breast cancer cells (MCF-7). The aqueous fruit extract was prepared. The synthesis of Ag-NSs under different conditions was optimized. The optimal reaction medium comprised 1:2 concentration of fruit extract and 3 mM concentration of silver nitrate solution. The green-synthesized Ag-NSs were confirmed by using UV-Visible spectroscopy at a range 300-700 nm, transmission electron microscopy (TEM), X-ray diffraction (XRD) and zeta potential measurements. The anti-proliferative activity of Ag-NSs was confirmed with inhibitory activity on MCF-7 cell line growth. The results showed that the IC50 values at 24 and 48h were 14.27 and 13.4 μg/ml, respectively. In conclusion the results of this study provide a simple, rapid, non-toxic and eco-friendly protocol for green-synthesis of Ag-NSs, which could be used as an alternative and interesting approach for safe and simple synthesis of Ag nanoparticles for biomedical uses. |
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Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell LineCytotoxicityGreen synthesisNanostructuresRhus coriariaSilverAbstract Rhus coriaria, popularly known as sumac, has been used as a spice powder in the Middle East for centuries. It contains a broad range of naturally occurring compounds such as flavonoids, proteins, anthocyanins and volatile oils. It showed a putative importance in treatment of different disorders including cancers. In the current study, R. coriaria fruit extract was used for green synthesis of silver nanostructures (Ag-NSs) and their anticancer activity was tested against human breast cancer cells (MCF-7). The aqueous fruit extract was prepared. The synthesis of Ag-NSs under different conditions was optimized. The optimal reaction medium comprised 1:2 concentration of fruit extract and 3 mM concentration of silver nitrate solution. The green-synthesized Ag-NSs were confirmed by using UV-Visible spectroscopy at a range 300-700 nm, transmission electron microscopy (TEM), X-ray diffraction (XRD) and zeta potential measurements. The anti-proliferative activity of Ag-NSs was confirmed with inhibitory activity on MCF-7 cell line growth. The results showed that the IC50 values at 24 and 48h were 14.27 and 13.4 μg/ml, respectively. In conclusion the results of this study provide a simple, rapid, non-toxic and eco-friendly protocol for green-synthesis of Ag-NSs, which could be used as an alternative and interesting approach for safe and simple synthesis of Ag nanoparticles for biomedical uses.Instituto de Tecnologia do Paraná - Tecpar2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132021000100428Brazilian Archives of Biology and Technology v.64 2021reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2021210069info:eu-repo/semantics/openAccessCharghadchi,MahtaGharari,ZahraSadighian,SomayehYazdinezhad,AlirezaSharafi,Alieng2022-01-07T00:00:00Zoai:scielo:S1516-89132021000100428Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2022-01-07T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line |
title |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line |
spellingShingle |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line Charghadchi,Mahta Cytotoxicity Green synthesis Nanostructures Rhus coriaria Silver |
title_short |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line |
title_full |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line |
title_fullStr |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line |
title_full_unstemmed |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line |
title_sort |
Green Synthesized Silver Nanostructure Using Rhus coriaria Fruit Extract Inhibits the Growth of Malignant MCF-7 Cell Line |
author |
Charghadchi,Mahta |
author_facet |
Charghadchi,Mahta Gharari,Zahra Sadighian,Somayeh Yazdinezhad,Alireza Sharafi,Ali |
author_role |
author |
author2 |
Gharari,Zahra Sadighian,Somayeh Yazdinezhad,Alireza Sharafi,Ali |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Charghadchi,Mahta Gharari,Zahra Sadighian,Somayeh Yazdinezhad,Alireza Sharafi,Ali |
dc.subject.por.fl_str_mv |
Cytotoxicity Green synthesis Nanostructures Rhus coriaria Silver |
topic |
Cytotoxicity Green synthesis Nanostructures Rhus coriaria Silver |
description |
Abstract Rhus coriaria, popularly known as sumac, has been used as a spice powder in the Middle East for centuries. It contains a broad range of naturally occurring compounds such as flavonoids, proteins, anthocyanins and volatile oils. It showed a putative importance in treatment of different disorders including cancers. In the current study, R. coriaria fruit extract was used for green synthesis of silver nanostructures (Ag-NSs) and their anticancer activity was tested against human breast cancer cells (MCF-7). The aqueous fruit extract was prepared. The synthesis of Ag-NSs under different conditions was optimized. The optimal reaction medium comprised 1:2 concentration of fruit extract and 3 mM concentration of silver nitrate solution. The green-synthesized Ag-NSs were confirmed by using UV-Visible spectroscopy at a range 300-700 nm, transmission electron microscopy (TEM), X-ray diffraction (XRD) and zeta potential measurements. The anti-proliferative activity of Ag-NSs was confirmed with inhibitory activity on MCF-7 cell line growth. The results showed that the IC50 values at 24 and 48h were 14.27 and 13.4 μg/ml, respectively. In conclusion the results of this study provide a simple, rapid, non-toxic and eco-friendly protocol for green-synthesis of Ag-NSs, which could be used as an alternative and interesting approach for safe and simple synthesis of Ag nanoparticles for biomedical uses. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132021000100428 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132021000100428 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4324-2021210069 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.64 2021 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
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1750318280578433024 |