Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000600010 |
Resumo: | The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group. The mice from the EMC group showed reductions in total cell numbers of ascitic fluid compared with those from the E, EC and EM groups. The combination of MI and CY was the most effective treatment for Ehrlich tumor ascites. |
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Brazilian Archives of Biology and Technology |
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Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor developmentLeucaena leucocephalaMimosineEhrlich tumorCyclophosphamideAnticancer activityThe effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group. The mice from the EMC group showed reductions in total cell numbers of ascitic fluid compared with those from the E, EC and EM groups. The combination of MI and CY was the most effective treatment for Ehrlich tumor ascites.Instituto de Tecnologia do Paraná - Tecpar2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000600010Brazilian Archives of Biology and Technology v.55 n.6 2012reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132012000600010info:eu-repo/semantics/openAccessDipe,Vânius ViníciusGotardo,André TadeuHaraguchi,MitsueGórniak,Silvana Limaeng2013-01-07T00:00:00Zoai:scielo:S1516-89132012000600010Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2013-01-07T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development |
title |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development |
spellingShingle |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development Dipe,Vânius Vinícius Leucaena leucocephala Mimosine Ehrlich tumor Cyclophosphamide Anticancer activity |
title_short |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development |
title_full |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development |
title_fullStr |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development |
title_full_unstemmed |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development |
title_sort |
Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development |
author |
Dipe,Vânius Vinícius |
author_facet |
Dipe,Vânius Vinícius Gotardo,André Tadeu Haraguchi,Mitsue Górniak,Silvana Lima |
author_role |
author |
author2 |
Gotardo,André Tadeu Haraguchi,Mitsue Górniak,Silvana Lima |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Dipe,Vânius Vinícius Gotardo,André Tadeu Haraguchi,Mitsue Górniak,Silvana Lima |
dc.subject.por.fl_str_mv |
Leucaena leucocephala Mimosine Ehrlich tumor Cyclophosphamide Anticancer activity |
topic |
Leucaena leucocephala Mimosine Ehrlich tumor Cyclophosphamide Anticancer activity |
description |
The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group. The mice from the EMC group showed reductions in total cell numbers of ascitic fluid compared with those from the E, EC and EM groups. The combination of MI and CY was the most effective treatment for Ehrlich tumor ascites. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000600010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000600010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132012000600010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.55 n.6 2012 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318275299901440 |