FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer

Detalhes bibliográficos
Autor(a) principal: Jiang,Wei
Data de Publicação: 2022
Outros Autores: Lu,Wei, Yang,Wenjie
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100338
Resumo: Abstract The potential of long noncoding RNAs (lncRNAs) as symptomatic and prognostic biomarkers in oncotherapy for hepatic carcinoma has been revealed. However, the specific mechanisms of lncRNA-regulated tumor progression and metastasis are not completely known. The RNA and miRNA sequencing data of liver cancer in The Cancer Genome Atlas database were analyzed. A competing endogenous RNA (ceRNA) was constructed, and its effects on the progression and metastasis of tumors and the survival rates of patients with tumor were evaluated. Differentially expressed mRNAs, miRNAs, and lncRNAs were identified. A liver cancer-associated ceRNA network, namely, FAM224A/hsa-mir-139/RAD54B, was then established. FAM224A/hsa-mir-139/RAD54B assumed a significant part in liver malignancy movement and metastasis. A series of cell experiments was conducted to prove the importance of ceRNAs, and the binding between RNAs was validated through a dual-luciferase reporter assay. The FAM224A/hsa-mir-139/RAD54B network in liver cancer was identified. FAM224A may be an important prognostic factor and treatment target for liver cancer.
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spelling FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancerlong noncoding RNAsbiomarkershepatic carcinoma.Abstract The potential of long noncoding RNAs (lncRNAs) as symptomatic and prognostic biomarkers in oncotherapy for hepatic carcinoma has been revealed. However, the specific mechanisms of lncRNA-regulated tumor progression and metastasis are not completely known. The RNA and miRNA sequencing data of liver cancer in The Cancer Genome Atlas database were analyzed. A competing endogenous RNA (ceRNA) was constructed, and its effects on the progression and metastasis of tumors and the survival rates of patients with tumor were evaluated. Differentially expressed mRNAs, miRNAs, and lncRNAs were identified. A liver cancer-associated ceRNA network, namely, FAM224A/hsa-mir-139/RAD54B, was then established. FAM224A/hsa-mir-139/RAD54B assumed a significant part in liver malignancy movement and metastasis. A series of cell experiments was conducted to prove the importance of ceRNAs, and the binding between RNAs was validated through a dual-luciferase reporter assay. The FAM224A/hsa-mir-139/RAD54B network in liver cancer was identified. FAM224A may be an important prognostic factor and treatment target for liver cancer.Instituto de Tecnologia do Paraná - Tecpar2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100338Brazilian Archives of Biology and Technology v.65 2022reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2022210652info:eu-repo/semantics/openAccessJiang,WeiLu,WeiYang,Wenjieeng2022-11-18T00:00:00Zoai:scielo:S1516-89132022000100338Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2022-11-18T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
title FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
spellingShingle FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
Jiang,Wei
long noncoding RNAs
biomarkers
hepatic carcinoma.
title_short FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
title_full FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
title_fullStr FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
title_full_unstemmed FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
title_sort FAM224A/hsa-mir-139/RAD54B is a Competing Endogenous RNA Network that may Serve as a New Prognostic Factor and Treatment Target for Liver Cancer
author Jiang,Wei
author_facet Jiang,Wei
Lu,Wei
Yang,Wenjie
author_role author
author2 Lu,Wei
Yang,Wenjie
author2_role author
author
dc.contributor.author.fl_str_mv Jiang,Wei
Lu,Wei
Yang,Wenjie
dc.subject.por.fl_str_mv long noncoding RNAs
biomarkers
hepatic carcinoma.
topic long noncoding RNAs
biomarkers
hepatic carcinoma.
description Abstract The potential of long noncoding RNAs (lncRNAs) as symptomatic and prognostic biomarkers in oncotherapy for hepatic carcinoma has been revealed. However, the specific mechanisms of lncRNA-regulated tumor progression and metastasis are not completely known. The RNA and miRNA sequencing data of liver cancer in The Cancer Genome Atlas database were analyzed. A competing endogenous RNA (ceRNA) was constructed, and its effects on the progression and metastasis of tumors and the survival rates of patients with tumor were evaluated. Differentially expressed mRNAs, miRNAs, and lncRNAs were identified. A liver cancer-associated ceRNA network, namely, FAM224A/hsa-mir-139/RAD54B, was then established. FAM224A/hsa-mir-139/RAD54B assumed a significant part in liver malignancy movement and metastasis. A series of cell experiments was conducted to prove the importance of ceRNAs, and the binding between RNAs was validated through a dual-luciferase reporter assay. The FAM224A/hsa-mir-139/RAD54B network in liver cancer was identified. FAM224A may be an important prognostic factor and treatment target for liver cancer.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100338
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100338
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-4324-2022210652
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.65 2022
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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