Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/001300000nt4g |
Texto Completo: | http://dx.doi.org/10.3390/genes8010006 https://repositorio.unifesp.br/handle/11600/56329 |
Resumo: | Tobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases. |
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Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseasesnoncoding RNAsmicroRNAslong noncoding RNAstobaccoalcoholcancerchronic obstructive pulmonary diseasecardiovascular diseasesTobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases.AC Camargo Canc Ctr, Mol Morphol Lab, BR-01508010 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, BrazilMolecular Gynecology Laboratory, Gynecologic Department, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FAPESP: 2014/03021-1Mdpi Ag2020-07-31T12:46:44Z2020-07-31T12:46:44Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-http://dx.doi.org/10.3390/genes8010006Genes. Basel, v. 8, n. 1, p. -, 2017.10.3390/genes80100062073-4425https://repositorio.unifesp.br/handle/11600/56329WOS:000399057100006ark:/48912/001300000nt4gengGenesBaselinfo:eu-repo/semantics/openAccessdo Amaral, Nayra SoaresMelo, Natalia Cruz e [UNIFESP]Maia, Beatriz de MeloRocha, Rafael Malagoli [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-10-05T15:46:41Zoai:repositorio.unifesp.br/:11600/56329Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:28:00.299042Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases |
title |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases |
spellingShingle |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases do Amaral, Nayra Soares noncoding RNAs microRNAs long noncoding RNAs tobacco alcohol cancer chronic obstructive pulmonary disease cardiovascular diseases |
title_short |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases |
title_full |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases |
title_fullStr |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases |
title_full_unstemmed |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases |
title_sort |
Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases |
author |
do Amaral, Nayra Soares |
author_facet |
do Amaral, Nayra Soares Melo, Natalia Cruz e [UNIFESP] Maia, Beatriz de Melo Rocha, Rafael Malagoli [UNIFESP] |
author_role |
author |
author2 |
Melo, Natalia Cruz e [UNIFESP] Maia, Beatriz de Melo Rocha, Rafael Malagoli [UNIFESP] |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
do Amaral, Nayra Soares Melo, Natalia Cruz e [UNIFESP] Maia, Beatriz de Melo Rocha, Rafael Malagoli [UNIFESP] |
dc.subject.por.fl_str_mv |
noncoding RNAs microRNAs long noncoding RNAs tobacco alcohol cancer chronic obstructive pulmonary disease cardiovascular diseases |
topic |
noncoding RNAs microRNAs long noncoding RNAs tobacco alcohol cancer chronic obstructive pulmonary disease cardiovascular diseases |
description |
Tobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2020-07-31T12:46:44Z 2020-07-31T12:46:44Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/genes8010006 Genes. Basel, v. 8, n. 1, p. -, 2017. 10.3390/genes8010006 2073-4425 https://repositorio.unifesp.br/handle/11600/56329 WOS:000399057100006 |
dc.identifier.dark.fl_str_mv |
ark:/48912/001300000nt4g |
url |
http://dx.doi.org/10.3390/genes8010006 https://repositorio.unifesp.br/handle/11600/56329 |
identifier_str_mv |
Genes. Basel, v. 8, n. 1, p. -, 2017. 10.3390/genes8010006 2073-4425 WOS:000399057100006 ark:/48912/001300000nt4g |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genes |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- |
dc.coverage.none.fl_str_mv |
Basel |
dc.publisher.none.fl_str_mv |
Mdpi Ag |
publisher.none.fl_str_mv |
Mdpi Ag |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1818602491310243840 |