Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases

Detalhes bibliográficos
Autor(a) principal: do Amaral, Nayra Soares
Data de Publicação: 2017
Outros Autores: Melo, Natalia Cruz e [UNIFESP], Maia, Beatriz de Melo, Rocha, Rafael Malagoli [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000nt4g
Texto Completo: http://dx.doi.org/10.3390/genes8010006
https://repositorio.unifesp.br/handle/11600/56329
Resumo: Tobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases.
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spelling Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseasesnoncoding RNAsmicroRNAslong noncoding RNAstobaccoalcoholcancerchronic obstructive pulmonary diseasecardiovascular diseasesTobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases.AC Camargo Canc Ctr, Mol Morphol Lab, BR-01508010 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, BrazilMolecular Gynecology Laboratory, Gynecologic Department, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FAPESP: 2014/03021-1Mdpi Ag2020-07-31T12:46:44Z2020-07-31T12:46:44Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-http://dx.doi.org/10.3390/genes8010006Genes. Basel, v. 8, n. 1, p. -, 2017.10.3390/genes80100062073-4425https://repositorio.unifesp.br/handle/11600/56329WOS:000399057100006ark:/48912/001300000nt4gengGenesBaselinfo:eu-repo/semantics/openAccessdo Amaral, Nayra SoaresMelo, Natalia Cruz e [UNIFESP]Maia, Beatriz de MeloRocha, Rafael Malagoli [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-10-05T15:46:41Zoai:repositorio.unifesp.br/:11600/56329Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:28:00.299042Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
title Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
spellingShingle Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
do Amaral, Nayra Soares
noncoding RNAs
microRNAs
long noncoding RNAs
tobacco
alcohol
cancer
chronic obstructive pulmonary disease
cardiovascular diseases
title_short Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
title_full Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
title_fullStr Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
title_full_unstemmed Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
title_sort Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases
author do Amaral, Nayra Soares
author_facet do Amaral, Nayra Soares
Melo, Natalia Cruz e [UNIFESP]
Maia, Beatriz de Melo
Rocha, Rafael Malagoli [UNIFESP]
author_role author
author2 Melo, Natalia Cruz e [UNIFESP]
Maia, Beatriz de Melo
Rocha, Rafael Malagoli [UNIFESP]
author2_role author
author
author
dc.contributor.author.fl_str_mv do Amaral, Nayra Soares
Melo, Natalia Cruz e [UNIFESP]
Maia, Beatriz de Melo
Rocha, Rafael Malagoli [UNIFESP]
dc.subject.por.fl_str_mv noncoding RNAs
microRNAs
long noncoding RNAs
tobacco
alcohol
cancer
chronic obstructive pulmonary disease
cardiovascular diseases
topic noncoding RNAs
microRNAs
long noncoding RNAs
tobacco
alcohol
cancer
chronic obstructive pulmonary disease
cardiovascular diseases
description Tobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways-primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-31T12:46:44Z
2020-07-31T12:46:44Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/genes8010006
Genes. Basel, v. 8, n. 1, p. -, 2017.
10.3390/genes8010006
2073-4425
https://repositorio.unifesp.br/handle/11600/56329
WOS:000399057100006
dc.identifier.dark.fl_str_mv ark:/48912/001300000nt4g
url http://dx.doi.org/10.3390/genes8010006
https://repositorio.unifesp.br/handle/11600/56329
identifier_str_mv Genes. Basel, v. 8, n. 1, p. -, 2017.
10.3390/genes8010006
2073-4425
WOS:000399057100006
ark:/48912/001300000nt4g
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genes
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
dc.coverage.none.fl_str_mv Basel
dc.publisher.none.fl_str_mv Mdpi Ag
publisher.none.fl_str_mv Mdpi Ag
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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