Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100627 |
Resumo: | Abstract Orally disintegrating films (ODFs) comprising hydroxypropyl methylcellulose (HPMC) E6 (2%, 2.5%, and 3%) and plasticizers (glycerin [Gly], propylene glycol [1], or polyethylene glycol [2]) containing CPT were prepared by the solvent casting method and characterized. The design of experiments (DoE) was used considering the amount of film-forming agent (HPMC) and the nature of the plasticizers as independent variables and thickness, mechanical properties, disintegration time, and dissolution efficiency as dependent variables. The best formulation was selected based on the desirability function (fD). Color analysis was performed using CIE-Lab coordinates. The films had a pH less than 4 and were thus suitable for maximum stability of CPT. The amount of HPMC E6 and the nature of the plasticizer play a critical role in the physical, mechanical, and physicochemical properties of the films. Principal component analysis and hierarchical cluster analysis revealed a more defined distinction of the ODFs according to their chromatic characteristics. ODFs prepared with Gly and PEG 400 were translucent, whereas the other films were transparent. DoE successfully facilitated the interpretation of the experimental data and allowed the identification of optimal values of the factors for maximum yield. The maximum value obtained for fD was 0.8520, corresponding to 2.0 - 2.5% of the polymer (HPMC E6), and PP as plasticizer. The best-fitting kinetics model for CPT release from the ODFs was the Korsmeyer-Peppas model. The results showed that orally disintegrating films can be a promising alternative for oral administration of captopril. |
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Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studiescaptoprildesign of experiments (DoE)desirability functionmechanical propertiesorally disintegrating film.Abstract Orally disintegrating films (ODFs) comprising hydroxypropyl methylcellulose (HPMC) E6 (2%, 2.5%, and 3%) and plasticizers (glycerin [Gly], propylene glycol [1], or polyethylene glycol [2]) containing CPT were prepared by the solvent casting method and characterized. The design of experiments (DoE) was used considering the amount of film-forming agent (HPMC) and the nature of the plasticizers as independent variables and thickness, mechanical properties, disintegration time, and dissolution efficiency as dependent variables. The best formulation was selected based on the desirability function (fD). Color analysis was performed using CIE-Lab coordinates. The films had a pH less than 4 and were thus suitable for maximum stability of CPT. The amount of HPMC E6 and the nature of the plasticizer play a critical role in the physical, mechanical, and physicochemical properties of the films. Principal component analysis and hierarchical cluster analysis revealed a more defined distinction of the ODFs according to their chromatic characteristics. ODFs prepared with Gly and PEG 400 were translucent, whereas the other films were transparent. DoE successfully facilitated the interpretation of the experimental data and allowed the identification of optimal values of the factors for maximum yield. The maximum value obtained for fD was 0.8520, corresponding to 2.0 - 2.5% of the polymer (HPMC E6), and PP as plasticizer. The best-fitting kinetics model for CPT release from the ODFs was the Korsmeyer-Peppas model. The results showed that orally disintegrating films can be a promising alternative for oral administration of captopril.Instituto de Tecnologia do Paraná - Tecpar2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100627Brazilian Archives of Biology and Technology v.65 2022reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/1678-4324-2022220073info:eu-repo/semantics/openAccessColucci,Larissa ArocaRodrigues,Leticia Norma Carpentierieng2022-09-06T00:00:00Zoai:scielo:S1516-89132022000100627Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2022-09-06T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies |
title |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies |
spellingShingle |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies Colucci,Larissa Aroca captopril design of experiments (DoE) desirability function mechanical properties orally disintegrating film. |
title_short |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies |
title_full |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies |
title_fullStr |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies |
title_full_unstemmed |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies |
title_sort |
Development of Orally Disintegrating Films HPMC-Based Containing Captopril: Mechanical, Optical and Physicochemical Studies |
author |
Colucci,Larissa Aroca |
author_facet |
Colucci,Larissa Aroca Rodrigues,Leticia Norma Carpentieri |
author_role |
author |
author2 |
Rodrigues,Leticia Norma Carpentieri |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Colucci,Larissa Aroca Rodrigues,Leticia Norma Carpentieri |
dc.subject.por.fl_str_mv |
captopril design of experiments (DoE) desirability function mechanical properties orally disintegrating film. |
topic |
captopril design of experiments (DoE) desirability function mechanical properties orally disintegrating film. |
description |
Abstract Orally disintegrating films (ODFs) comprising hydroxypropyl methylcellulose (HPMC) E6 (2%, 2.5%, and 3%) and plasticizers (glycerin [Gly], propylene glycol [1], or polyethylene glycol [2]) containing CPT were prepared by the solvent casting method and characterized. The design of experiments (DoE) was used considering the amount of film-forming agent (HPMC) and the nature of the plasticizers as independent variables and thickness, mechanical properties, disintegration time, and dissolution efficiency as dependent variables. The best formulation was selected based on the desirability function (fD). Color analysis was performed using CIE-Lab coordinates. The films had a pH less than 4 and were thus suitable for maximum stability of CPT. The amount of HPMC E6 and the nature of the plasticizer play a critical role in the physical, mechanical, and physicochemical properties of the films. Principal component analysis and hierarchical cluster analysis revealed a more defined distinction of the ODFs according to their chromatic characteristics. ODFs prepared with Gly and PEG 400 were translucent, whereas the other films were transparent. DoE successfully facilitated the interpretation of the experimental data and allowed the identification of optimal values of the factors for maximum yield. The maximum value obtained for fD was 0.8520, corresponding to 2.0 - 2.5% of the polymer (HPMC E6), and PP as plasticizer. The best-fitting kinetics model for CPT release from the ODFs was the Korsmeyer-Peppas model. The results showed that orally disintegrating films can be a promising alternative for oral administration of captopril. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100627 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132022000100627 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4324-2022220073 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.65 2022 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318281697263616 |