Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500007 |
Resumo: | The tolerability of stevioside (2.75 mg/kg/day) obtained from leaves of Stevia rebaudiana (Bert) Bertoni (Compositae) was investigated in hyperlipidemic patients. For this purpose a placebo controlled double blind study was performed. The patients were randomized in two groups: the first group received capsules containing placebo and the second group received capsules containing stevioside (50 mg) during 90 days. All capsules were ingested twice daily, i.e., 2 capsules before lunch and 2 capsules before dinner. After the selection of the patients and each 30 days body mass index and laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, total cholesterol, high density lipoprotein, low density lipoprotein, very low density lipoprotein, triglycerides and glucose) were performed. Stevioside did not show any clinical relevant modification in all parameters investigated. Moreover the patients did not report severe adverse effect. Thus, we can concluded that stevioside, at least in the doses employed in this study was safe. |
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Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patientsStevia rebaudiana (Bert) Bertonisteviosideclinical investigationplacebo effectThe tolerability of stevioside (2.75 mg/kg/day) obtained from leaves of Stevia rebaudiana (Bert) Bertoni (Compositae) was investigated in hyperlipidemic patients. For this purpose a placebo controlled double blind study was performed. The patients were randomized in two groups: the first group received capsules containing placebo and the second group received capsules containing stevioside (50 mg) during 90 days. All capsules were ingested twice daily, i.e., 2 capsules before lunch and 2 capsules before dinner. After the selection of the patients and each 30 days body mass index and laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, total cholesterol, high density lipoprotein, low density lipoprotein, very low density lipoprotein, triglycerides and glucose) were performed. Stevioside did not show any clinical relevant modification in all parameters investigated. Moreover the patients did not report severe adverse effect. Thus, we can concluded that stevioside, at least in the doses employed in this study was safe.Instituto de Tecnologia do Paraná - Tecpar2006-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500007Brazilian Archives of Biology and Technology v.49 n.4 2006reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132006000500007info:eu-repo/semantics/openAccessSilva,Gisleine Elisa Cavalcante daAssef,Abdol HakinAlbino,Claudio CordeiroFerri,Letícia de Araujo FunariTasin,GilsonTakahashi,Mirian HidekoEik Filho,WilsonBazotte,Roberto Barbosaeng2006-08-30T00:00:00Zoai:scielo:S1516-89132006000500007Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2006-08-30T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients |
title |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients |
spellingShingle |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients Silva,Gisleine Elisa Cavalcante da Stevia rebaudiana (Bert) Bertoni stevioside clinical investigation placebo effect |
title_short |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients |
title_full |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients |
title_fullStr |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients |
title_full_unstemmed |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients |
title_sort |
Investigation of the tolerability of oral stevioside in Brazilian hyperlipidemic patients |
author |
Silva,Gisleine Elisa Cavalcante da |
author_facet |
Silva,Gisleine Elisa Cavalcante da Assef,Abdol Hakin Albino,Claudio Cordeiro Ferri,Letícia de Araujo Funari Tasin,Gilson Takahashi,Mirian Hideko Eik Filho,Wilson Bazotte,Roberto Barbosa |
author_role |
author |
author2 |
Assef,Abdol Hakin Albino,Claudio Cordeiro Ferri,Letícia de Araujo Funari Tasin,Gilson Takahashi,Mirian Hideko Eik Filho,Wilson Bazotte,Roberto Barbosa |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Gisleine Elisa Cavalcante da Assef,Abdol Hakin Albino,Claudio Cordeiro Ferri,Letícia de Araujo Funari Tasin,Gilson Takahashi,Mirian Hideko Eik Filho,Wilson Bazotte,Roberto Barbosa |
dc.subject.por.fl_str_mv |
Stevia rebaudiana (Bert) Bertoni stevioside clinical investigation placebo effect |
topic |
Stevia rebaudiana (Bert) Bertoni stevioside clinical investigation placebo effect |
description |
The tolerability of stevioside (2.75 mg/kg/day) obtained from leaves of Stevia rebaudiana (Bert) Bertoni (Compositae) was investigated in hyperlipidemic patients. For this purpose a placebo controlled double blind study was performed. The patients were randomized in two groups: the first group received capsules containing placebo and the second group received capsules containing stevioside (50 mg) during 90 days. All capsules were ingested twice daily, i.e., 2 capsules before lunch and 2 capsules before dinner. After the selection of the patients and each 30 days body mass index and laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, total cholesterol, high density lipoprotein, low density lipoprotein, very low density lipoprotein, triglycerides and glucose) were performed. Stevioside did not show any clinical relevant modification in all parameters investigated. Moreover the patients did not report severe adverse effect. Thus, we can concluded that stevioside, at least in the doses employed in this study was safe. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132006000500007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.49 n.4 2006 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318271103500288 |