Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa

Detalhes bibliográficos
Autor(a) principal: Chiavegatto, Raquel Bezerra
Data de Publicação: 2017
Outros Autores: Chaves, Ana Luisa Arantes, Silva, Izabela Caputo Assis, Lima, Luciana Alves Rodrigues dos Santos, Techio, Vânia Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Scientiarum Biological Sciences
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/34082
Resumo:  Solanum lycocarpum St.-Hil popularly known as ‘fruta-de-lobo’ or ‘lobeira’ is native to the Brazilian Cerrado, and used in folk medicine due to its phytotherapic properties. The action of S. lycocarpum on the cell cycle and chromosomes in order to demonstrate whether there are aneugenic and/or clastogenic effects is unknown. Thus, this study aimed at investigating the cytotoxic and genotoxic potential of methanol and hexane extracts of S. lycocarpum on growth and cell cycle of Lactuca sativa and Allium cepa. Roots from both species were exposed for 72 hours to methanol and hexane extracts with 50, 100, and 200 µg mL-1 of S. lycocarpum. Slides were prepared by the squash technique and then analyzed to determine the mitotic index and the total of chromosomal and nuclear abnormalities. The frequencies of chromosomal and nuclear abnormalities were high and significant with a dose-dependent effect, indicating that S. lycocarpum has a cytotoxic and genotoxic action depending on the dose used on meristem cells of A. cepa and L. sativa. 
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spelling Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepaaneugenicCerradoclastogeniclobeiramedicinal plant.Citologia Solanum lycocarpum St.-Hil popularly known as ‘fruta-de-lobo’ or ‘lobeira’ is native to the Brazilian Cerrado, and used in folk medicine due to its phytotherapic properties. The action of S. lycocarpum on the cell cycle and chromosomes in order to demonstrate whether there are aneugenic and/or clastogenic effects is unknown. Thus, this study aimed at investigating the cytotoxic and genotoxic potential of methanol and hexane extracts of S. lycocarpum on growth and cell cycle of Lactuca sativa and Allium cepa. Roots from both species were exposed for 72 hours to methanol and hexane extracts with 50, 100, and 200 µg mL-1 of S. lycocarpum. Slides were prepared by the squash technique and then analyzed to determine the mitotic index and the total of chromosomal and nuclear abnormalities. The frequencies of chromosomal and nuclear abnormalities were high and significant with a dose-dependent effect, indicating that S. lycocarpum has a cytotoxic and genotoxic action depending on the dose used on meristem cells of A. cepa and L. sativa. Universidade Estadual De Maringá2017-06-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/3408210.4025/actascibiolsci.v39i2.34082Acta Scientiarum. Biological Sciences; Vol 39 No 2 (2017); 201-210Acta Scientiarum. Biological Sciences; v. 39 n. 2 (2017); 201-2101807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/34082/pdfCopyright (c) 2017 Acta Scientiarum. Biological Sciencesinfo:eu-repo/semantics/openAccessChiavegatto, Raquel BezerraChaves, Ana Luisa ArantesSilva, Izabela Caputo AssisLima, Luciana Alves Rodrigues dos SantosTechio, Vânia Helena2022-02-17T22:00:22Zoai:periodicos.uem.br/ojs:article/34082Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-02-17T22:00:22Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
title Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
spellingShingle Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
Chiavegatto, Raquel Bezerra
aneugenic
Cerrado
clastogenic
lobeira
medicinal plant.
Citologia
title_short Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
title_full Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
title_fullStr Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
title_full_unstemmed Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
title_sort Cytotoxic and genotoxic effects of Solanum lycocarpum St.-Hil (Solanaceae) on the cell cycle of Lactuca sativa and Allium cepa
author Chiavegatto, Raquel Bezerra
author_facet Chiavegatto, Raquel Bezerra
Chaves, Ana Luisa Arantes
Silva, Izabela Caputo Assis
Lima, Luciana Alves Rodrigues dos Santos
Techio, Vânia Helena
author_role author
author2 Chaves, Ana Luisa Arantes
Silva, Izabela Caputo Assis
Lima, Luciana Alves Rodrigues dos Santos
Techio, Vânia Helena
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Chiavegatto, Raquel Bezerra
Chaves, Ana Luisa Arantes
Silva, Izabela Caputo Assis
Lima, Luciana Alves Rodrigues dos Santos
Techio, Vânia Helena
dc.subject.por.fl_str_mv aneugenic
Cerrado
clastogenic
lobeira
medicinal plant.
Citologia
topic aneugenic
Cerrado
clastogenic
lobeira
medicinal plant.
Citologia
description  Solanum lycocarpum St.-Hil popularly known as ‘fruta-de-lobo’ or ‘lobeira’ is native to the Brazilian Cerrado, and used in folk medicine due to its phytotherapic properties. The action of S. lycocarpum on the cell cycle and chromosomes in order to demonstrate whether there are aneugenic and/or clastogenic effects is unknown. Thus, this study aimed at investigating the cytotoxic and genotoxic potential of methanol and hexane extracts of S. lycocarpum on growth and cell cycle of Lactuca sativa and Allium cepa. Roots from both species were exposed for 72 hours to methanol and hexane extracts with 50, 100, and 200 µg mL-1 of S. lycocarpum. Slides were prepared by the squash technique and then analyzed to determine the mitotic index and the total of chromosomal and nuclear abnormalities. The frequencies of chromosomal and nuclear abnormalities were high and significant with a dose-dependent effect, indicating that S. lycocarpum has a cytotoxic and genotoxic action depending on the dose used on meristem cells of A. cepa and L. sativa. 
publishDate 2017
dc.date.none.fl_str_mv 2017-06-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/34082
10.4025/actascibiolsci.v39i2.34082
url http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/34082
identifier_str_mv 10.4025/actascibiolsci.v39i2.34082
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/34082/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2017 Acta Scientiarum. Biological Sciences
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Acta Scientiarum. Biological Sciences
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Biological Sciences; Vol 39 No 2 (2017); 201-210
Acta Scientiarum. Biological Sciences; v. 39 n. 2 (2017); 201-210
1807-863X
1679-9283
reponame:Acta Scientiarum Biological Sciences
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta Scientiarum Biological Sciences
collection Acta Scientiarum Biological Sciences
repository.name.fl_str_mv Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actabiol@uem.br
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