Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/30572 |
Resumo: | Staphylococcus aureus infection may lead to the development of soft tissue damage. It has been evaluated in other researches using different animal models. In addition, the inflammatory response developed by the host organism facing an infection by this pathogen has been analyzed and neutrophils have been linked to the immune response developed. In this study, we aimed to compare the inflammatory response developed by the host induced by an intradermal infection with a methicillin-resistant strain of Staphylococcus aureus (MRSA) or a methicillin-susceptible strain of Staphylococcus aureus (MSSA). Mice euthanasia occurred in the following times: 6, 24, 48 and 96 hours of infection; the cell number and the cytokine release were evaluated. Our results showed that infections by different strains of Staphylococcus aureus lead to different immune response degrees. Although MRSA infection induces higher neutrophil recruitment to the infection site and higher inflammatory response in the draining lymph node, the increased production of TNF-α, IFN-γ, IL-6 and IL-1β in the lymph node 6 hours after the infection was observed only in MSSA infected animals. Considering the data, MSSA may have mechanisms to prevent neutrophil recruitment to the infection site. |
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Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infectionNeutrophillymph nodeMRSAMicrobiologiaStaphylococcus aureus infection may lead to the development of soft tissue damage. It has been evaluated in other researches using different animal models. In addition, the inflammatory response developed by the host organism facing an infection by this pathogen has been analyzed and neutrophils have been linked to the immune response developed. In this study, we aimed to compare the inflammatory response developed by the host induced by an intradermal infection with a methicillin-resistant strain of Staphylococcus aureus (MRSA) or a methicillin-susceptible strain of Staphylococcus aureus (MSSA). Mice euthanasia occurred in the following times: 6, 24, 48 and 96 hours of infection; the cell number and the cytokine release were evaluated. Our results showed that infections by different strains of Staphylococcus aureus lead to different immune response degrees. Although MRSA infection induces higher neutrophil recruitment to the infection site and higher inflammatory response in the draining lymph node, the increased production of TNF-α, IFN-γ, IL-6 and IL-1β in the lymph node 6 hours after the infection was observed only in MSSA infected animals. Considering the data, MSSA may have mechanisms to prevent neutrophil recruitment to the infection site. Universidade Estadual De Maringá2016-12-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionResposta imuneapplication/pdfapplication/ziphttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/3057210.4025/actascibiolsci.v38i4.30572Acta Scientiarum. Biological Sciences; Vol 38 No 4 (2016); 457-464Acta Scientiarum. Biological Sciences; v. 38 n. 4 (2016); 457-4641807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/30572/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/30572/751375144510Copyright (c) 2016 Acta Scientiarum. Biological Sciencesinfo:eu-repo/semantics/openAccessSantana, HugoFerreira, Lício Fábio Almeida AndradePereira, Ítalo SousaMarques, Lucas MirandaFiqueiredo, Tiana BaqueiroSilva, Robson Amaro Augusto da2022-02-20T22:00:20Zoai:periodicos.uem.br/ojs:article/30572Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-02-20T22:00:20Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection |
title |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection |
spellingShingle |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection Santana, Hugo Neutrophil lymph node MRSA Microbiologia |
title_short |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection |
title_full |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection |
title_fullStr |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection |
title_full_unstemmed |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection |
title_sort |
Distinct strains of Staphylococcus aureus lead to different inflammatory response patterns in a murine model of intradermal infection |
author |
Santana, Hugo |
author_facet |
Santana, Hugo Ferreira, Lício Fábio Almeida Andrade Pereira, Ítalo Sousa Marques, Lucas Miranda Fiqueiredo, Tiana Baqueiro Silva, Robson Amaro Augusto da |
author_role |
author |
author2 |
Ferreira, Lício Fábio Almeida Andrade Pereira, Ítalo Sousa Marques, Lucas Miranda Fiqueiredo, Tiana Baqueiro Silva, Robson Amaro Augusto da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santana, Hugo Ferreira, Lício Fábio Almeida Andrade Pereira, Ítalo Sousa Marques, Lucas Miranda Fiqueiredo, Tiana Baqueiro Silva, Robson Amaro Augusto da |
dc.subject.por.fl_str_mv |
Neutrophil lymph node MRSA Microbiologia |
topic |
Neutrophil lymph node MRSA Microbiologia |
description |
Staphylococcus aureus infection may lead to the development of soft tissue damage. It has been evaluated in other researches using different animal models. In addition, the inflammatory response developed by the host organism facing an infection by this pathogen has been analyzed and neutrophils have been linked to the immune response developed. In this study, we aimed to compare the inflammatory response developed by the host induced by an intradermal infection with a methicillin-resistant strain of Staphylococcus aureus (MRSA) or a methicillin-susceptible strain of Staphylococcus aureus (MSSA). Mice euthanasia occurred in the following times: 6, 24, 48 and 96 hours of infection; the cell number and the cytokine release were evaluated. Our results showed that infections by different strains of Staphylococcus aureus lead to different immune response degrees. Although MRSA infection induces higher neutrophil recruitment to the infection site and higher inflammatory response in the draining lymph node, the increased production of TNF-α, IFN-γ, IL-6 and IL-1β in the lymph node 6 hours after the infection was observed only in MSSA infected animals. Considering the data, MSSA may have mechanisms to prevent neutrophil recruitment to the infection site. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Resposta imune |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/30572 10.4025/actascibiolsci.v38i4.30572 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/30572 |
identifier_str_mv |
10.4025/actascibiolsci.v38i4.30572 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/30572/pdf http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/30572/751375144510 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Acta Scientiarum. Biological Sciences info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Acta Scientiarum. Biological Sciences |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/zip |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 38 No 4 (2016); 457-464 Acta Scientiarum. Biological Sciences; v. 38 n. 4 (2016); 457-464 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
_version_ |
1799317396432879616 |