Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060
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Data de Publicação: | 2011 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Acta scientiarum. Technology (Online) |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/8060 |
Resumo: | Paclitaxel, as known Taxol®, is an important agent in cancer treatment, founded in mixture with many structural analogs, or taxanes, present in natural source or plant tissue culture broth. The adsorption techniques are used in the purification of placlitaxel from that complex mixture, but despite of the strategy it is important to know the basic parameters associated with any process, such as isotherms and mass transfer parameters. In this paper is presented a simple model to estimate these parameters by moment analysis. After to consider linear isotherm for adsorption, the partition coefficient, free and effective diffusion coefficients of paclitaxel and four major components, in a plant tissue culture broth, were estimated from the first and second moments of peaks in pulse-elution chromatograms. The experimental chromatograms at two flow rates are compared with those ones from model, also proposed in this work. The experimental results of free diffusion coefficient are compared with that ones from the Literature. |
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Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060Cancertaxolmass transfeEngenharia QuímicaPaclitaxel, as known Taxol®, is an important agent in cancer treatment, founded in mixture with many structural analogs, or taxanes, present in natural source or plant tissue culture broth. The adsorption techniques are used in the purification of placlitaxel from that complex mixture, but despite of the strategy it is important to know the basic parameters associated with any process, such as isotherms and mass transfer parameters. In this paper is presented a simple model to estimate these parameters by moment analysis. After to consider linear isotherm for adsorption, the partition coefficient, free and effective diffusion coefficients of paclitaxel and four major components, in a plant tissue culture broth, were estimated from the first and second moments of peaks in pulse-elution chromatograms. The experimental chromatograms at two flow rates are compared with those ones from model, also proposed in this work. The experimental results of free diffusion coefficient are compared with that ones from the Literature.Universidade Estadual De Maringá2011-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioncromatografia ; técnica de momentos cromatográficos ; modelagem ; simulaçãoapplication/pdfapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/806010.4025/actascitechnol.v34i1.8060Acta Scientiarum. Technology; Vol 34 No 1 (2012); 33-40Acta Scientiarum. Technology; v. 34 n. 1 (2012); 33-401806-25631807-8664reponame:Acta scientiarum. Technology (Online)instname:Universidade Estadual de Maringá (UEM)instacron:UEMengporhttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/8060/8060http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/8060/8060aCremasco, Marco AurélioWang, Linda Nien-Hwainfo:eu-repo/semantics/openAccess2024-05-17T13:03:11Zoai:periodicos.uem.br/ojs:article/8060Revistahttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/indexPUBhttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/oai||actatech@uem.br1807-86641806-2563opendoar:2024-05-17T13:03:11Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 |
title |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 |
spellingShingle |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 Cremasco, Marco Aurélio Cancer taxol mass transfe Engenharia Química |
title_short |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 |
title_full |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 |
title_fullStr |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 |
title_full_unstemmed |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 |
title_sort |
Estimation of partition, free and specific diffusion coefficients of paclitaxel and taxanes in a fixed bed by moment analysis: experimental, modeling and simulation studies - doi: 10.4025/actascitechnol.v34i1.8060 |
author |
Cremasco, Marco Aurélio |
author_facet |
Cremasco, Marco Aurélio Wang, Linda Nien-Hwa |
author_role |
author |
author2 |
Wang, Linda Nien-Hwa |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Cremasco, Marco Aurélio Wang, Linda Nien-Hwa |
dc.subject.por.fl_str_mv |
Cancer taxol mass transfe Engenharia Química |
topic |
Cancer taxol mass transfe Engenharia Química |
description |
Paclitaxel, as known Taxol®, is an important agent in cancer treatment, founded in mixture with many structural analogs, or taxanes, present in natural source or plant tissue culture broth. The adsorption techniques are used in the purification of placlitaxel from that complex mixture, but despite of the strategy it is important to know the basic parameters associated with any process, such as isotherms and mass transfer parameters. In this paper is presented a simple model to estimate these parameters by moment analysis. After to consider linear isotherm for adsorption, the partition coefficient, free and effective diffusion coefficients of paclitaxel and four major components, in a plant tissue culture broth, were estimated from the first and second moments of peaks in pulse-elution chromatograms. The experimental chromatograms at two flow rates are compared with those ones from model, also proposed in this work. The experimental results of free diffusion coefficient are compared with that ones from the Literature. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion cromatografia ; técnica de momentos cromatográficos ; modelagem ; simulação |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/8060 10.4025/actascitechnol.v34i1.8060 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/8060 |
identifier_str_mv |
10.4025/actascitechnol.v34i1.8060 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/8060/8060 http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/8060/8060a |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Technology; Vol 34 No 1 (2012); 33-40 Acta Scientiarum. Technology; v. 34 n. 1 (2012); 33-40 1806-2563 1807-8664 reponame:Acta scientiarum. Technology (Online) instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta scientiarum. Technology (Online) |
collection |
Acta scientiarum. Technology (Online) |
repository.name.fl_str_mv |
Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actatech@uem.br |
_version_ |
1799315333769592832 |