Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry

Detalhes bibliográficos
Autor(a) principal: Martins, Sarah Moherdaui
Data de Publicação: 2018
Outros Autores: Rosa, Mauricio Ferreira da, Souza, Fábio, Galan, Vanderson, Muller, Vinícius, Andreazza, Itamar Francisco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta scientiarum. Technology (Online)
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754
Resumo:  Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL-1, which allows it for routine use in quality control laboratories. 
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spelling Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometrybiphasic releasemultiparticulate systempellets. Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL-1, which allows it for routine use in quality control laboratories. Universidade Estadual De Maringá2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionvalidaçãoapplication/pdfapplication/pdfapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/3075410.4025/actascitechnol.v40i1.30754Acta Scientiarum. Technology; Vol 40 (2018): Publicação Contínua; e30754Acta Scientiarum. Technology; v. 40 (2018): Publicação Contínua; e307541806-25631807-8664reponame:Acta scientiarum. Technology (Online)instname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754/751375146331http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754/751375146332Copyright (c) 2017 Acta Scientiarum. Technologyinfo:eu-repo/semantics/openAccessMartins, Sarah MoherdauiRosa, Mauricio Ferreira daSouza, FábioGalan, VandersonMuller, ViníciusAndreazza, Itamar Francisco2019-07-17T11:53:47Zoai:periodicos.uem.br/ojs:article/30754Revistahttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/indexPUBhttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/oai||actatech@uem.br1807-86641806-2563opendoar:2019-07-17T11:53:47Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
title Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
spellingShingle Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
Martins, Sarah Moherdaui
biphasic release
multiparticulate system
pellets.
title_short Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
title_full Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
title_fullStr Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
title_full_unstemmed Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
title_sort Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry
author Martins, Sarah Moherdaui
author_facet Martins, Sarah Moherdaui
Rosa, Mauricio Ferreira da
Souza, Fábio
Galan, Vanderson
Muller, Vinícius
Andreazza, Itamar Francisco
author_role author
author2 Rosa, Mauricio Ferreira da
Souza, Fábio
Galan, Vanderson
Muller, Vinícius
Andreazza, Itamar Francisco
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Martins, Sarah Moherdaui
Rosa, Mauricio Ferreira da
Souza, Fábio
Galan, Vanderson
Muller, Vinícius
Andreazza, Itamar Francisco
dc.subject.por.fl_str_mv biphasic release
multiparticulate system
pellets.
topic biphasic release
multiparticulate system
pellets.
description  Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL-1, which allows it for routine use in quality control laboratories. 
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
validação
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754
10.4025/actascitechnol.v40i1.30754
url http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754
identifier_str_mv 10.4025/actascitechnol.v40i1.30754
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754/pdf
http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754/751375146331
http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/30754/751375146332
dc.rights.driver.fl_str_mv Copyright (c) 2017 Acta Scientiarum. Technology
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Acta Scientiarum. Technology
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Technology; Vol 40 (2018): Publicação Contínua; e30754
Acta Scientiarum. Technology; v. 40 (2018): Publicação Contínua; e30754
1806-2563
1807-8664
reponame:Acta scientiarum. Technology (Online)
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta scientiarum. Technology (Online)
collection Acta scientiarum. Technology (Online)
repository.name.fl_str_mv Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actatech@uem.br
_version_ 1799315336360624128

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