Physical characterization of multiparticulate systems

Detalhes bibliográficos
Autor(a) principal: Issa, Michele Georges
Data de Publicação: 2017
Outros Autores: de Souza, Natalia Vieira, Duque, Marcelo Dutra [UNIFESP], Ferraz, Humberto Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/s2175-97902017000400216
https://repositorio.unifesp.br/handle/11600/55281
Resumo: The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the ensuing stages of manufacture, as well as the final product. Therefore, the characterization of these small units is of fundamental importance for achieving batch homogeneity and optimal product performance. Analyses, including particle size distribution, morphology, density, porosity, mechanical strength and disintegration, are example tests used in this characterization. The objective of this review was to address the most widely used tests for the physical evaluation of multiparticulate systems.
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spelling Physical characterization of multiparticulate systemsMultiparticulate systems/physical characterizationPelletsGranulesMinitabletsThe search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the ensuing stages of manufacture, as well as the final product. Therefore, the characterization of these small units is of fundamental importance for achieving batch homogeneity and optimal product performance. Analyses, including particle size distribution, morphology, density, porosity, mechanical strength and disintegration, are example tests used in this characterization. The objective of this review was to address the most widely used tests for the physical evaluation of multiparticulate systems.Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Sao Paulo, BrazilWeb of ScienceUniv Sao Paulo, Conjunto Quimicas2020-07-17T14:03:17Z2020-07-17T14:03:17Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1590/s2175-97902017000400216Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 53, n. 4, p. -, 2017.10.1590/s2175-97902017000400216S1984-82502017000400403.pdf1984-8250S1984-82502017000400403https://repositorio.unifesp.br/handle/11600/55281WOS:000431767900001engBrazilian Journal Of Pharmaceutical SciencesSao Pauloinfo:eu-repo/semantics/openAccessIssa, Michele Georgesde Souza, Natalia VieiraDuque, Marcelo Dutra [UNIFESP]Ferraz, Humberto Gomesreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T07:01:27Zoai:repositorio.unifesp.br/:11600/55281Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T07:01:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Physical characterization of multiparticulate systems
title Physical characterization of multiparticulate systems
spellingShingle Physical characterization of multiparticulate systems
Issa, Michele Georges
Multiparticulate systems/physical characterization
Pellets
Granules
Minitablets
title_short Physical characterization of multiparticulate systems
title_full Physical characterization of multiparticulate systems
title_fullStr Physical characterization of multiparticulate systems
title_full_unstemmed Physical characterization of multiparticulate systems
title_sort Physical characterization of multiparticulate systems
author Issa, Michele Georges
author_facet Issa, Michele Georges
de Souza, Natalia Vieira
Duque, Marcelo Dutra [UNIFESP]
Ferraz, Humberto Gomes
author_role author
author2 de Souza, Natalia Vieira
Duque, Marcelo Dutra [UNIFESP]
Ferraz, Humberto Gomes
author2_role author
author
author
dc.contributor.author.fl_str_mv Issa, Michele Georges
de Souza, Natalia Vieira
Duque, Marcelo Dutra [UNIFESP]
Ferraz, Humberto Gomes
dc.subject.por.fl_str_mv Multiparticulate systems/physical characterization
Pellets
Granules
Minitablets
topic Multiparticulate systems/physical characterization
Pellets
Granules
Minitablets
description The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the ensuing stages of manufacture, as well as the final product. Therefore, the characterization of these small units is of fundamental importance for achieving batch homogeneity and optimal product performance. Analyses, including particle size distribution, morphology, density, porosity, mechanical strength and disintegration, are example tests used in this characterization. The objective of this review was to address the most widely used tests for the physical evaluation of multiparticulate systems.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-17T14:03:17Z
2020-07-17T14:03:17Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/s2175-97902017000400216
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 53, n. 4, p. -, 2017.
10.1590/s2175-97902017000400216
S1984-82502017000400403.pdf
1984-8250
S1984-82502017000400403
https://repositorio.unifesp.br/handle/11600/55281
WOS:000431767900001
url http://dx.doi.org/10.1590/s2175-97902017000400216
https://repositorio.unifesp.br/handle/11600/55281
identifier_str_mv Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 53, n. 4, p. -, 2017.
10.1590/s2175-97902017000400216
S1984-82502017000400403.pdf
1984-8250
S1984-82502017000400403
WOS:000431767900001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal Of Pharmaceutical Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
publisher.none.fl_str_mv Univ Sao Paulo, Conjunto Quimicas
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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