Physical characterization of multiparticulate systems
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/s2175-97902017000400216 https://repositorio.unifesp.br/handle/11600/55281 |
Resumo: | The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the ensuing stages of manufacture, as well as the final product. Therefore, the characterization of these small units is of fundamental importance for achieving batch homogeneity and optimal product performance. Analyses, including particle size distribution, morphology, density, porosity, mechanical strength and disintegration, are example tests used in this characterization. The objective of this review was to address the most widely used tests for the physical evaluation of multiparticulate systems. |
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Physical characterization of multiparticulate systemsMultiparticulate systems/physical characterizationPelletsGranulesMinitabletsThe search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the ensuing stages of manufacture, as well as the final product. Therefore, the characterization of these small units is of fundamental importance for achieving batch homogeneity and optimal product performance. Analyses, including particle size distribution, morphology, density, porosity, mechanical strength and disintegration, are example tests used in this characterization. The objective of this review was to address the most widely used tests for the physical evaluation of multiparticulate systems.Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Sao Paulo, BrazilWeb of ScienceUniv Sao Paulo, Conjunto Quimicas2020-07-17T14:03:17Z2020-07-17T14:03:17Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1590/s2175-97902017000400216Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 53, n. 4, p. -, 2017.10.1590/s2175-97902017000400216S1984-82502017000400403.pdf1984-8250S1984-82502017000400403https://repositorio.unifesp.br/handle/11600/55281WOS:000431767900001engBrazilian Journal Of Pharmaceutical SciencesSao Pauloinfo:eu-repo/semantics/openAccessIssa, Michele Georgesde Souza, Natalia VieiraDuque, Marcelo Dutra [UNIFESP]Ferraz, Humberto Gomesreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T07:01:27Zoai:repositorio.unifesp.br/:11600/55281Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T07:01:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Physical characterization of multiparticulate systems |
title |
Physical characterization of multiparticulate systems |
spellingShingle |
Physical characterization of multiparticulate systems Issa, Michele Georges Multiparticulate systems/physical characterization Pellets Granules Minitablets |
title_short |
Physical characterization of multiparticulate systems |
title_full |
Physical characterization of multiparticulate systems |
title_fullStr |
Physical characterization of multiparticulate systems |
title_full_unstemmed |
Physical characterization of multiparticulate systems |
title_sort |
Physical characterization of multiparticulate systems |
author |
Issa, Michele Georges |
author_facet |
Issa, Michele Georges de Souza, Natalia Vieira Duque, Marcelo Dutra [UNIFESP] Ferraz, Humberto Gomes |
author_role |
author |
author2 |
de Souza, Natalia Vieira Duque, Marcelo Dutra [UNIFESP] Ferraz, Humberto Gomes |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Issa, Michele Georges de Souza, Natalia Vieira Duque, Marcelo Dutra [UNIFESP] Ferraz, Humberto Gomes |
dc.subject.por.fl_str_mv |
Multiparticulate systems/physical characterization Pellets Granules Minitablets |
topic |
Multiparticulate systems/physical characterization Pellets Granules Minitablets |
description |
The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the ensuing stages of manufacture, as well as the final product. Therefore, the characterization of these small units is of fundamental importance for achieving batch homogeneity and optimal product performance. Analyses, including particle size distribution, morphology, density, porosity, mechanical strength and disintegration, are example tests used in this characterization. The objective of this review was to address the most widely used tests for the physical evaluation of multiparticulate systems. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2020-07-17T14:03:17Z 2020-07-17T14:03:17Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s2175-97902017000400216 Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 53, n. 4, p. -, 2017. 10.1590/s2175-97902017000400216 S1984-82502017000400403.pdf 1984-8250 S1984-82502017000400403 https://repositorio.unifesp.br/handle/11600/55281 WOS:000431767900001 |
url |
http://dx.doi.org/10.1590/s2175-97902017000400216 https://repositorio.unifesp.br/handle/11600/55281 |
identifier_str_mv |
Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 53, n. 4, p. -, 2017. 10.1590/s2175-97902017000400216 S1984-82502017000400403.pdf 1984-8250 S1984-82502017000400403 WOS:000431767900001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal Of Pharmaceutical Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- application/pdf |
dc.coverage.none.fl_str_mv |
Sao Paulo |
dc.publisher.none.fl_str_mv |
Univ Sao Paulo, Conjunto Quimicas |
publisher.none.fl_str_mv |
Univ Sao Paulo, Conjunto Quimicas |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268385056260096 |