Studies about micronucleited eritrocites in mice treataded with anabolizantes

Detalhes bibliográficos
Autor(a) principal: Contar, Juida de Deus Palma
Data de Publicação: 2008
Outros Autores: Valim, Simone Busko, Castro, Valéria Sena de, Sardeti, Viviane Aparecida, Guedes, Terezinha Aparecida
Tipo de documento: Artigo
Idioma: por
Título da fonte: Journal of Physical Education (Maringá)
Texto Completo: https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3785
Resumo: Drugs as cobamamid and ubidecarenone have been used by different sportsmen as a treatment to gain fast muscular mass. Literature shows modulation of haematopoietic toxicity associated with these drugs. An evaluation of the results obtained in an in vivo study to assess the effectiveness of cobamamid and ubidecarenone administered to normal mice is discussed in this paper. The sample was compared with controls that received distilled water or cyclophosphamide. The haematopoietic toxicity was evaluated by MN(micronucleus) test in bone marrow cells. Statistical analysis with ANOVA and paired Student “t”and Tuckey “T” tests were used to determine the significance of MN polychromatic erythrocytis (PE) and normochromatic erythrocytes (NE) in different groups. Both isolated and associated drug administration revealed mutagenesis index effect as may be seen in the data table and those results require special caution for further studies.
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spelling Studies about micronucleited eritrocites in mice treataded with anabolizantesESTUDOS SOBRE A LEITURA DE ERITRÓCITOS MICRONUCLEADOS EM CAMUNDONGOS TRATADOS COM ANABOLIZANTEScamundongosmedula ósseacobamamidaubidecarenonamicronúcleos4.09.00.00-2 Educação FísicaDrugs as cobamamid and ubidecarenone have been used by different sportsmen as a treatment to gain fast muscular mass. Literature shows modulation of haematopoietic toxicity associated with these drugs. An evaluation of the results obtained in an in vivo study to assess the effectiveness of cobamamid and ubidecarenone administered to normal mice is discussed in this paper. The sample was compared with controls that received distilled water or cyclophosphamide. The haematopoietic toxicity was evaluated by MN(micronucleus) test in bone marrow cells. Statistical analysis with ANOVA and paired Student “t”and Tuckey “T” tests were used to determine the significance of MN polychromatic erythrocytis (PE) and normochromatic erythrocytes (NE) in different groups. Both isolated and associated drug administration revealed mutagenesis index effect as may be seen in the data table and those results require special caution for further studies.Os anabolizantes são substâncias utilizadas para aumento rápido da massa muscular. Na população usuária estão diferentes segmentos sociais, inclusive aqueles candidatos às competições esportivas que necessitam de resultados urgentes. A bibliografia e a própria bula dos medicamentos registram efeitos no sistema hematopoiético. Diante desses fatos e da linha de pesquisa desenvolvida pelo laboratório de Psicobiologia, nos dispusemos a analisar duas destas substâncias, Cobamamida e Ubidecarenona. Nesta análise, foi feita também a leitura microscópica de células eritrocitárias da medula óssea de camundongo, onde se registrou a presença de Micronúcleos (MN) em Eritrócitos Policromáticos (EP) e Eritrócitos Normocromáticos (EN). A avaliação estatística entre os grupos controle e tratados foi realizada, inicialmente, pela análise de variância seguida dos testes “t” de Student e "T" de Tukey. O efeito indicador de mutagenicidade no estudo das substâncias se apresentou nas administrações, isoladas ou associadas das mesmas. Logo, cuidados especiais devem ser tomados diante dos resultados obtidos.Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil2008-06-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3785Journal of Physical Education; Vol 11 No 1 (2000); 3-10Journal of Physical Education; Vol. 11 Núm. 1 (2000); 3-10Journal of Physical Education; v. 11 n. 1 (2000); 3-102448-2455reponame:Journal of Physical Education (Maringá)instname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3785/2601Contar, Juida de Deus PalmaValim, Simone BuskoCastro, Valéria Sena deSardeti, Viviane AparecidaGuedes, Terezinha Aparecidainfo:eu-repo/semantics/openAccess2023-01-10T15:37:22Zoai:periodicos.uem.br/ojs:article/3785Revistahttp://periodicos.uem.br/ojs/index.php/RevEducFis/indexPUBhttps://old.scielo.br/oai/scielo-oai.php||revdef@uem.br2448-24552448-2455opendoar:2023-01-10T15:37:22Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Studies about micronucleited eritrocites in mice treataded with anabolizantes
ESTUDOS SOBRE A LEITURA DE ERITRÓCITOS MICRONUCLEADOS EM CAMUNDONGOS TRATADOS COM ANABOLIZANTES
title Studies about micronucleited eritrocites in mice treataded with anabolizantes
spellingShingle Studies about micronucleited eritrocites in mice treataded with anabolizantes
Contar, Juida de Deus Palma
camundongos
medula óssea
cobamamida
ubidecarenona
micronúcleos
4.09.00.00-2 Educação Física
title_short Studies about micronucleited eritrocites in mice treataded with anabolizantes
title_full Studies about micronucleited eritrocites in mice treataded with anabolizantes
title_fullStr Studies about micronucleited eritrocites in mice treataded with anabolizantes
title_full_unstemmed Studies about micronucleited eritrocites in mice treataded with anabolizantes
title_sort Studies about micronucleited eritrocites in mice treataded with anabolizantes
author Contar, Juida de Deus Palma
author_facet Contar, Juida de Deus Palma
Valim, Simone Busko
Castro, Valéria Sena de
Sardeti, Viviane Aparecida
Guedes, Terezinha Aparecida
author_role author
author2 Valim, Simone Busko
Castro, Valéria Sena de
Sardeti, Viviane Aparecida
Guedes, Terezinha Aparecida
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Contar, Juida de Deus Palma
Valim, Simone Busko
Castro, Valéria Sena de
Sardeti, Viviane Aparecida
Guedes, Terezinha Aparecida
dc.subject.por.fl_str_mv camundongos
medula óssea
cobamamida
ubidecarenona
micronúcleos
4.09.00.00-2 Educação Física
topic camundongos
medula óssea
cobamamida
ubidecarenona
micronúcleos
4.09.00.00-2 Educação Física
description Drugs as cobamamid and ubidecarenone have been used by different sportsmen as a treatment to gain fast muscular mass. Literature shows modulation of haematopoietic toxicity associated with these drugs. An evaluation of the results obtained in an in vivo study to assess the effectiveness of cobamamid and ubidecarenone administered to normal mice is discussed in this paper. The sample was compared with controls that received distilled water or cyclophosphamide. The haematopoietic toxicity was evaluated by MN(micronucleus) test in bone marrow cells. Statistical analysis with ANOVA and paired Student “t”and Tuckey “T” tests were used to determine the significance of MN polychromatic erythrocytis (PE) and normochromatic erythrocytes (NE) in different groups. Both isolated and associated drug administration revealed mutagenesis index effect as may be seen in the data table and those results require special caution for further studies.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-06
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3785
url https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3785
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3785/2601
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
dc.source.none.fl_str_mv Journal of Physical Education; Vol 11 No 1 (2000); 3-10
Journal of Physical Education; Vol. 11 Núm. 1 (2000); 3-10
Journal of Physical Education; v. 11 n. 1 (2000); 3-10
2448-2455
reponame:Journal of Physical Education (Maringá)
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Journal of Physical Education (Maringá)
collection Journal of Physical Education (Maringá)
repository.name.fl_str_mv Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||revdef@uem.br
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