Controle populacional do protozoário Giardia lamblia com resultados experimentais

• Autor(a) principal: Freitas, Wilton dos Santos de
• Data de Publicação: 2022
• Outros Autores: [e-mail]
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/19369
• topic: Electronic engineering; Biological systems; Non-linear systems; Feedback control systems; Convergence; Engenharia eletrônica; Sistemas biológicos; Sistemas não-lineares; Sistemas de controle por realimentação; Convergência; ENGENHARIAS::ENGENHARIA ELETRICA::ELETRONICA INDUSTRIAL, SISTEMAS E CONTROLES ELETRONICOS

Giardia lamblia is a flagellate intestinal protozoan with global distribution causing the disease known as giardiasis. This parasite is responsable for 35.1% of outbreaks of diarrhea caused by contaminated water which and mainly affects children in whom it can cause physical and cognitive impairment. In this dissertation, we consider a model of population dynamics based on evolutionary game theory to represent the behavior of G. lamblia in vitro, taking into account its characteristic of resisting the action of the drug metronidazole. Different from what is found in the literature, it is pursued as the control objective the extermination of the protozoan considering that the parameters of the model are uncertain and only the partial measurement of the state vector is available. On these assumptions, a control law is designed such that proofs of convergence are rigorously demonstrated for the closed-loop system. At the end, simulation and experimental results the benefits of the proposed population control methods of Giardia lamblia.