Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UERJ |
Texto Completo: | http://www.bdtd.uerj.br/handle/1/18643 |
Resumo: | This thesis aimed to evaluate the relationship between preterm birth, low birth weight (LBW) and impaired renal function. To this end, two studies were developed. The first was an integrative literature review with the aim of gathering the most recent scientific publications on the influence of prematurity on the development of chronic kidney disease (CKD). Publications from 2016 to 2020, in Portuguese and English, were considered that addressed the relationship between prematurity and development of kidney disease, as well as the mechanisms that explain this association, based on the hypothesis that preterm newborns are most vulnerable to CKD. The search strategy was carried out using the electronic databases USA National Library of Medicine (Medline/PubMed), Virtual Health Library (Bireme/Lilacs) and Cochrane Library, from the combination and free use of terms indexed on the Mesh platform: premature birth; infant, premature; kidney disease; kidney failure, chronic; renal insufficiency. Initial selection was performed by two independent evaluators, with screening of articles of interest based on the evaluation of titles and abstracts. When not enlightening, the article was read in full. Repeated articles were excluded and disagreements between evaluators were resolved by consensus. Qualitative analysis of studies was used for synthesis and interpretation of results. Recent studies have shown the effect of prematurity on the risk of developing CKD, although more robust evidence is needed to guide formal guidelines for monitoring children born prematurely, from childhood to adulthood. The second was a cross-sectional study, with the objective of evaluating the association of renal deficit with maternal characteristics and in LBW children discharged from the Neonatal Intensive Care Unit (NICU). Maternal and child-related data were obtained through electronic medical records and outpatient consultations. To estimate the glomerular filtration rate (GFR) the combined equation of Zapittelli (2006) was used. A logistic regression analysis was performed in which renal deficit, represented by GFR<60 mL/min/1.73m², was an outcome variable and maternal characteristics, independent variables. Confounding variables related to children were controlled for. The prevalence of deficit in renal function among the 154 children evaluated was 34.42%. Most children with impaired renal function were male (56.6%), gestational age >32 weeks (56.6%), mean birth weight of 1439.7±347.5 grams and mean estimates of GFR of 46.9±9.3 mL/min/1.73m². During the evaluation period, children who were heavier had a lower risk of developing renal function deficit (OR=0.803; CI=0.650-0.993) and having used nephrotoxic drugs during NICU stay increased the chance of this deficit (OR=2.781; IC=1.095-7.061). It is concluded that weight may act as a protective factor for renal function deficit among children who were born with low birth weight, while the use of nephrotoxic drugs during NICU admission increases the chance of this deficit. The maternal characteristics evaluated were not related to impaired renal function. |
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Duarte, José Luiz Muniz Bandeirahttp://lattes.cnpq.br/6553758511709385Salgado Filho, Natalinohttp://lattes.cnpq.br/5510231622420489Lago, Marcos Junqueira dohttp://lattes.cnpq.br/7733476742225474Kuschnir, Maria Cristina Caetanohttp://lattes.cnpq.br/0802995003202530Ribeiro, Valdinar Sousahttp://lattes.cnpq.br/5229108144608248Bastos, Kleyton de Andradehttp://lattes.cnpq.br/6507146290532682http://lattes.cnpq.br/6592249004736678Vale, Marynéa Silva domaryneavale@gmail.com2022-11-10T16:25:29Z2022-07-12VALE, Marynéa Silva do. Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal. 2022. 108 f. Tese (Doutorado em Ciências Médicas) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2022.http://www.bdtd.uerj.br/handle/1/18643This thesis aimed to evaluate the relationship between preterm birth, low birth weight (LBW) and impaired renal function. To this end, two studies were developed. The first was an integrative literature review with the aim of gathering the most recent scientific publications on the influence of prematurity on the development of chronic kidney disease (CKD). Publications from 2016 to 2020, in Portuguese and English, were considered that addressed the relationship between prematurity and development of kidney disease, as well as the mechanisms that explain this association, based on the hypothesis that preterm newborns are most vulnerable to CKD. The search strategy was carried out using the electronic databases USA National Library of Medicine (Medline/PubMed), Virtual Health Library (Bireme/Lilacs) and Cochrane Library, from the combination and free use of terms indexed on the Mesh platform: premature birth; infant, premature; kidney disease; kidney failure, chronic; renal insufficiency. Initial selection was performed by two independent evaluators, with screening of articles of interest based on the evaluation of titles and abstracts. When not enlightening, the article was read in full. Repeated articles were excluded and disagreements between evaluators were resolved by consensus. Qualitative analysis of studies was used for synthesis and interpretation of results. Recent studies have shown the effect of prematurity on the risk of developing CKD, although more robust evidence is needed to guide formal guidelines for monitoring children born prematurely, from childhood to adulthood. The second was a cross-sectional study, with the objective of evaluating the association of renal deficit with maternal characteristics and in LBW children discharged from the Neonatal Intensive Care Unit (NICU). Maternal and child-related data were obtained through electronic medical records and outpatient consultations. To estimate the glomerular filtration rate (GFR) the combined equation of Zapittelli (2006) was used. A logistic regression analysis was performed in which renal deficit, represented by GFR<60 mL/min/1.73m², was an outcome variable and maternal characteristics, independent variables. Confounding variables related to children were controlled for. The prevalence of deficit in renal function among the 154 children evaluated was 34.42%. Most children with impaired renal function were male (56.6%), gestational age >32 weeks (56.6%), mean birth weight of 1439.7±347.5 grams and mean estimates of GFR of 46.9±9.3 mL/min/1.73m². During the evaluation period, children who were heavier had a lower risk of developing renal function deficit (OR=0.803; CI=0.650-0.993) and having used nephrotoxic drugs during NICU stay increased the chance of this deficit (OR=2.781; IC=1.095-7.061). It is concluded that weight may act as a protective factor for renal function deficit among children who were born with low birth weight, while the use of nephrotoxic drugs during NICU admission increases the chance of this deficit. The maternal characteristics evaluated were not related to impaired renal function.Esta tese teve o objetivo de avaliar a relação entre o nascimento prematuro, baixo peso ao nascer (BPN) e déficit da função renal. Para tal, foram desenvolvidos dois estudos. O primeiro foi uma revisão integrativa da literatura com o objetivo de reunir as publicações científicas mais recentes sobre a influência da prematuridade no desenvolvimento da doença renal crônica (DRC). Foram consideradas as publicações do período de 2016 a 2020, nos idiomas português e inglês que abordaram a relação entre prematuridade e desenvolvimento da doença renal bem como os mecanismos que explicam tal associação, a partir da hipótese de que os recém-nascidos pré-termo são mais vulneráveis à DRC. A estratégia de busca ocorreu utilizando as bases de dados eletrônicas USA National Library of Medicine (Medline/PubMed), Biblioteca Virtual em Saúde (Bireme/Lilacs) e Biblioteca Cochrane, a partir da combinação e do uso livre dos termos indexados na plataforma Mesh: premature birth; infant; premature; kidney disease; kidney failure; chronic; renal insufficiency. Foi realizada seleção inicial por dois avaliadores independentes, com triagem dos artigos de interesse a partir da avaliação dos títulos e dos resumos. Quando não esclarecedores, realizou-se a leitura do artigo na íntegra. Foram excluídos artigos repetidos e as discordâncias entre os avaliadores foram resolvidas por consenso. Utilizou-se análise qualitativa dos estudos para síntese e interpretação dos resultados. Verificou-se que os estudos recentes apontam o efeito da prematuridade sobre o risco de desenvolvimento da DRC, apesar de serem necessárias evidências mais robustas para nortear as orientações formais de acompanhamento de crianças nascidas de parto prematuro, desde a infância até a vida adulta. O segundo foi um estudo transversal, com o objetivo de avaliar associação de déficit renal com características maternas e de crianças com BPN egressos de Unidade de Terapia Intensiva Neonatal (UTIN). Foram obtidos dados maternos e relacionados às crianças por meio de prontuários eletrônicos e de consultas no ambulatório. Para estimativa da taxa de filtração glomerular (TFG) utilizou-se a equação combinada de Zapittelli (2006). Realizada análise de regressão logística em que déficit renal, representado por TFG<60 mL/min/1,73m² constituiu variável desfecho e características maternas, variáveis independentes. Variáveis de confundimento relacionadas às crianças foram controladas. A prevalência de déficit na função renal entre as 154 crianças avaliadas foi de 34,42%. A maioria das crianças com déficit na função renal era do sexo masculino (56,6%), idade gestacional >32 semanas (56,6%), média de peso ao nascer de 1439,7±347,5 gramas e estimativas médias de TFG de 46,9±9,3 mL/min/1,73m². No período da avaliação, as crianças que apresentavam maior peso tiveram menor risco de desenvolver déficit da função renal (OR=0,803; IC=0,650-0,993) e ter usado drogas nefrotóxicas durante internação em UTIN aumentou a chance desse déficit (OR=2,781; IC=1,095-7,061). Conclui-se que o peso pode atuar como fator protetor para déficit da função renal entre crianças que nasceram com baixo peso, enquanto o uso de drogas nefrotóxicas durante internação em UTIN aumenta a chance desse déficit. As características maternas avaliadas não estiveram relacionadas ao déficit da função renal.Submitted by Heloísa CB/A (helobdtd@gmail.com) on 2022-11-10T16:25:29Z No. of bitstreams: 1 Tese - Marynéa Silva do Vale - 2022 - Completo.pdf: 9329007 bytes, checksum: 5c5ec63e4141683029872b9da95baf54 (MD5)Made available in DSpace on 2022-11-10T16:25:29Z (GMT). No. of bitstreams: 1 Tese - Marynéa Silva do Vale - 2022 - Completo.pdf: 9329007 bytes, checksum: 5c5ec63e4141683029872b9da95baf54 (MD5) Previous issue date: 2022-07-12application/pdfporUniversidade do Estado do Rio de JaneiroPrograma de Pós-Graduação em Ciências MédicasUERJBrasilCentro Biomédico::Faculdade de Ciências MédicasInfantPremature BirthLow-birth-weightGlomerular filtration rateRenal functionCreatinineCystatin CCriançaNascimento prematuroBaixo peso ao nascerTaxa de filtração glomerularFunção renalCreatininaCistatina CCIENCIAS DA SAUDEAvaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renalRenal deficit and associated factors in infants born with low birth weightinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UERJinstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UERJORIGINALTese - Marynéa Silva do Vale - 2022 - Completo.pdfTese - Marynéa Silva do Vale - 2022 - Completo.pdfapplication/pdf9329007http://www.bdtd.uerj.br/bitstream/1/18643/2/Tese+-+Maryn%C3%A9a+Silva+do+Vale+-+2022+-+Completo.pdf5c5ec63e4141683029872b9da95baf54MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82123http://www.bdtd.uerj.br/bitstream/1/18643/1/license.txte5502652da718045d7fcd832b79fca29MD511/186432024-02-26 15:59:54.047oai:www.bdtd.uerj.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.bdtd.uerj.br/PUBhttps://www.bdtd.uerj.br:8443/oai/requestbdtd.suporte@uerj.bropendoar:29032024-02-26T18:59:54Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ)false |
dc.title.por.fl_str_mv |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal |
dc.title.alternative.eng.fl_str_mv |
Renal deficit and associated factors in infants born with low birth weight |
title |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal |
spellingShingle |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal Vale, Marynéa Silva do Infant Premature Birth Low-birth-weight Glomerular filtration rate Renal function Creatinine Cystatin C Criança Nascimento prematuro Baixo peso ao nascer Taxa de filtração glomerular Função renal Creatinina Cistatina C CIENCIAS DA SAUDE |
title_short |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal |
title_full |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal |
title_fullStr |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal |
title_full_unstemmed |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal |
title_sort |
Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal |
author |
Vale, Marynéa Silva do |
author_facet |
Vale, Marynéa Silva do maryneavale@gmail.com |
author_role |
author |
author2 |
maryneavale@gmail.com |
author2_role |
author |
dc.contributor.advisor1.fl_str_mv |
Duarte, José Luiz Muniz Bandeira |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6553758511709385 |
dc.contributor.advisor-co1.fl_str_mv |
Salgado Filho, Natalino |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/5510231622420489 |
dc.contributor.referee1.fl_str_mv |
Lago, Marcos Junqueira do |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/7733476742225474 |
dc.contributor.referee2.fl_str_mv |
Kuschnir, Maria Cristina Caetano |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/0802995003202530 |
dc.contributor.referee3.fl_str_mv |
Ribeiro, Valdinar Sousa |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/5229108144608248 |
dc.contributor.referee4.fl_str_mv |
Bastos, Kleyton de Andrade |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/6507146290532682 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6592249004736678 |
dc.contributor.author.fl_str_mv |
Vale, Marynéa Silva do maryneavale@gmail.com |
contributor_str_mv |
Duarte, José Luiz Muniz Bandeira Salgado Filho, Natalino Lago, Marcos Junqueira do Kuschnir, Maria Cristina Caetano Ribeiro, Valdinar Sousa Bastos, Kleyton de Andrade |
dc.subject.eng.fl_str_mv |
Infant Premature Birth Low-birth-weight Glomerular filtration rate Renal function Creatinine Cystatin C |
topic |
Infant Premature Birth Low-birth-weight Glomerular filtration rate Renal function Creatinine Cystatin C Criança Nascimento prematuro Baixo peso ao nascer Taxa de filtração glomerular Função renal Creatinina Cistatina C CIENCIAS DA SAUDE |
dc.subject.por.fl_str_mv |
Criança Nascimento prematuro Baixo peso ao nascer Taxa de filtração glomerular Função renal Creatinina Cistatina C |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
This thesis aimed to evaluate the relationship between preterm birth, low birth weight (LBW) and impaired renal function. To this end, two studies were developed. The first was an integrative literature review with the aim of gathering the most recent scientific publications on the influence of prematurity on the development of chronic kidney disease (CKD). Publications from 2016 to 2020, in Portuguese and English, were considered that addressed the relationship between prematurity and development of kidney disease, as well as the mechanisms that explain this association, based on the hypothesis that preterm newborns are most vulnerable to CKD. The search strategy was carried out using the electronic databases USA National Library of Medicine (Medline/PubMed), Virtual Health Library (Bireme/Lilacs) and Cochrane Library, from the combination and free use of terms indexed on the Mesh platform: premature birth; infant, premature; kidney disease; kidney failure, chronic; renal insufficiency. Initial selection was performed by two independent evaluators, with screening of articles of interest based on the evaluation of titles and abstracts. When not enlightening, the article was read in full. Repeated articles were excluded and disagreements between evaluators were resolved by consensus. Qualitative analysis of studies was used for synthesis and interpretation of results. Recent studies have shown the effect of prematurity on the risk of developing CKD, although more robust evidence is needed to guide formal guidelines for monitoring children born prematurely, from childhood to adulthood. The second was a cross-sectional study, with the objective of evaluating the association of renal deficit with maternal characteristics and in LBW children discharged from the Neonatal Intensive Care Unit (NICU). Maternal and child-related data were obtained through electronic medical records and outpatient consultations. To estimate the glomerular filtration rate (GFR) the combined equation of Zapittelli (2006) was used. A logistic regression analysis was performed in which renal deficit, represented by GFR<60 mL/min/1.73m², was an outcome variable and maternal characteristics, independent variables. Confounding variables related to children were controlled for. The prevalence of deficit in renal function among the 154 children evaluated was 34.42%. Most children with impaired renal function were male (56.6%), gestational age >32 weeks (56.6%), mean birth weight of 1439.7±347.5 grams and mean estimates of GFR of 46.9±9.3 mL/min/1.73m². During the evaluation period, children who were heavier had a lower risk of developing renal function deficit (OR=0.803; CI=0.650-0.993) and having used nephrotoxic drugs during NICU stay increased the chance of this deficit (OR=2.781; IC=1.095-7.061). It is concluded that weight may act as a protective factor for renal function deficit among children who were born with low birth weight, while the use of nephrotoxic drugs during NICU admission increases the chance of this deficit. The maternal characteristics evaluated were not related to impaired renal function. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-11-10T16:25:29Z |
dc.date.issued.fl_str_mv |
2022-07-12 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VALE, Marynéa Silva do. Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal. 2022. 108 f. Tese (Doutorado em Ciências Médicas) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2022. |
dc.identifier.uri.fl_str_mv |
http://www.bdtd.uerj.br/handle/1/18643 |
identifier_str_mv |
VALE, Marynéa Silva do. Avaliação da relação entre o nascimento prematuro, baixo peso ao nascer e déficit da função renal. 2022. 108 f. Tese (Doutorado em Ciências Médicas) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2022. |
url |
http://www.bdtd.uerj.br/handle/1/18643 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Médicas |
dc.publisher.initials.fl_str_mv |
UERJ |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro Biomédico::Faculdade de Ciências Médicas |
publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UERJ instname:Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
instname_str |
Universidade do Estado do Rio de Janeiro (UERJ) |
instacron_str |
UERJ |
institution |
UERJ |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UERJ |
collection |
Biblioteca Digital de Teses e Dissertações da UERJ |
bitstream.url.fl_str_mv |
http://www.bdtd.uerj.br/bitstream/1/18643/2/Tese+-+Maryn%C3%A9a+Silva+do+Vale+-+2022+-+Completo.pdf http://www.bdtd.uerj.br/bitstream/1/18643/1/license.txt |
bitstream.checksum.fl_str_mv |
5c5ec63e4141683029872b9da95baf54 e5502652da718045d7fcd832b79fca29 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ) |
repository.mail.fl_str_mv |
bdtd.suporte@uerj.br |
_version_ |
1811728720664199168 |