Redução dos níveis de IL-18 no fundo gengival após tratamento periodontal não-cirúrgico

• Autor(a) principal: Campos, Bernardo Oliveira de
• Data de Publicação: 2008
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/14130
• topic: Periodontitis; Interleukin-18; Periodontal treatment; Periodontite; Interleuquina-18; Tratamento periodontal; Periodontite - Tratamento; Gengivite - Tratamento; Interleucina-18; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::PERIODONTIA

The aim of that study was to evaluate the effect of the non surgical treatment on the levels of the IL-18 in inflamed sites from patients with periodontal disease. 14 patient with disease periodontal were appraised, being 9 patient with chronic periodontitis (mean age 48,8, SD± 7,4 years) and 5 patient with gingivitis (mean age: 43,6 SD± 11,8). The patients were divided in: gingivitis sites from periodontitis patients (sites GP), periodontitis sites from periodontitis patients (sites PP), and gingivitis sites from gingivitis patients (sites GG). The patients were evaluated at the baseline, they received non surgical periodontal treatment, and they were evaluated again 30 days after. The clinical parameters used at the baseline and 30 was: Plaque Index (PI), gingival Index (GI), visible plaque Index (VPI), bleeding on probing (BOP), pocket depth (PD) and attachment loss (AL). Collections of fluid gengival were accomplished (FG) in 5 sites GP, 5 sites PP and in 5 sites GG for patient at the baseline and 30 days. VPI reduced significantly from 33,7% to 10,7%. The % of sites with PBS >4 mm it reduced significantly from 81,7% to 53,4%. When all sites (GG, GP, PP) was analyzed together, there was a significant reduction for the levels of IL-18, PI, GI and PD. It was concluded that there was a significant reduction of the levels of IL-18 in inflamed sites from patients with periodontal disease accompanied by a significant improvement in the parameters clinical periodontais.