Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy

Detalhes bibliográficos
Autor(a) principal: Bahia, Fabianna Márcia Maranhão
Data de Publicação: 2004
Outros Autores: Pedroso, Célia, Martins Netto, Eduardo, Figueiredo, Ricardo, Pinto Neto, Lauro, Brites, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6780
Resumo: p.281-289
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spelling Bahia, Fabianna Márcia MaranhãoPedroso, CéliaMartins Netto, EduardoFigueiredo, RicardoPinto Neto, LauroBrites, CarlosBahia, Fabianna Márcia MaranhãoPedroso, CéliaMartins Netto, EduardoFigueiredo, RicardoPinto Neto, LauroBrites, Carlos2012-09-25T17:30:16Z2012-09-25T17:30:16Z20041413-8670http://www.repositorio.ufba.br/ri/handle/ri/6780v. 8, n. 4p.281-289We analyzed the first 96 patients tested for HIV resistance to antiretroviral therapy in three Brazilian states. The HIV-1 reverse transcriptase (RT) and protease (PR) were sequenced by using the ABI ViroSeq system. The drugs previously used for each patient were recorded and correlated with the mutations found in the samples. Viral load (VL) and CD4 count were also recorded. Only one patient had the wild type sequence. The most prevalent mutations were: 184V (59%), 41L (47.9%), 63P (53%), 215Y (50%), 36I (46%), 10I (35%), 67N (42%), 77I (37%), 90M (36%) and 210W (33%). A positive correlation between the number of previously used ARVs and the number of mutations was observed (p<0.05). Associations between mutations and ARV drugs were identified at positions 69, 118, 184 and 215 with previous exposure to NRTI, mutations at positions 98, 100, 103, 181 and 190 with previous NNRTI use and at positions 10, 20, 30, 46, 53, 54, 71, 73, 82, 84, 88 and 90 with previous PI therapy (p<0.05). Previous exposure to ARV drugs was associated with previous genotypic resistance to specific drugs, leading to treatment failure in HIV patients. Genotypic resistance was clearly associated with virological and immunological failure.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-25T17:30:15Z No. of bitstreams: 1 Bahia, Fabianna.pdf: 67683 bytes, checksum: c97d538dc4b6a7bc96a8396ec7d81e10 (MD5)Made available in DSpace on 2012-09-25T17:30:16Z (GMT). No. of bitstreams: 1 Bahia, Fabianna.pdf: 67683 bytes, checksum: c97d538dc4b6a7bc96a8396ec7d81e10 (MD5) Previous issue date: 2004-08SalvadorThe Brazilian Journal of Infectious Diseases and Contexto Publishinghttp://dx.doi.org/10.1590/S1413-86702004000400003reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHIV-1MutationsResistanceAntiretroviralsEvaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapyBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALBahia, Fabianna.pdfBahia, Fabianna.pdfapplication/pdf67683https://repositorio.ufba.br/bitstream/ri/6780/1/Bahia%2c%20Fabianna.pdfc97d538dc4b6a7bc96a8396ec7d81e10MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6780/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTBahia, Fabianna.pdf.txtBahia, Fabianna.pdf.txtExtracted texttext/plain22934https://repositorio.ufba.br/bitstream/ri/6780/3/Bahia%2c%20Fabianna.pdf.txt511fcccd70a54550dc2d035a4d7a2383MD53ri/67802022-09-23 08:42:25.633oai:repositorio.ufba.br:ri/6780VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-23T11:42:25Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
spellingShingle Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
Bahia, Fabianna Márcia Maranhão
HIV-1
Mutations
Resistance
Antiretrovirals
title_short Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
title_full Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
title_fullStr Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
title_full_unstemmed Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
title_sort Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
author Bahia, Fabianna Márcia Maranhão
author_facet Bahia, Fabianna Márcia Maranhão
Pedroso, Célia
Martins Netto, Eduardo
Figueiredo, Ricardo
Pinto Neto, Lauro
Brites, Carlos
author_role author
author2 Pedroso, Célia
Martins Netto, Eduardo
Figueiredo, Ricardo
Pinto Neto, Lauro
Brites, Carlos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bahia, Fabianna Márcia Maranhão
Pedroso, Célia
Martins Netto, Eduardo
Figueiredo, Ricardo
Pinto Neto, Lauro
Brites, Carlos
Bahia, Fabianna Márcia Maranhão
Pedroso, Célia
Martins Netto, Eduardo
Figueiredo, Ricardo
Pinto Neto, Lauro
Brites, Carlos
dc.subject.por.fl_str_mv HIV-1
Mutations
Resistance
Antiretrovirals
topic HIV-1
Mutations
Resistance
Antiretrovirals
description p.281-289
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-09-25T17:30:16Z
dc.date.available.fl_str_mv 2012-09-25T17:30:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6780
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 8, n. 4
identifier_str_mv 1413-8670
v. 8, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/6780
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702004000400003
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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