HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400009 |
Resumo: | Antiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated the genotypic profile of HIV-1 isolates from treated (drug-experienced) patients in Paraná, Brazil. The prevalence of mutations in reverse transcriptase (RT) and protease (PR) genes were assessed. We analyzed 467 genotypes of patients with HIV-1 viral loads above 1,000 copies/mL. Mutations at HIV-1 RT and PR genes and previously used ART regimens were recorded. The most prevalent RT mutations were: 184V (68.31%), 215YF (51.6%), 103NS (46%), 41L (39.4%), 67N (38.54%), 210W (23.5%), 190ASE (23.2%), and 181C (17.4%). PR mutations were 90M (33.33%), 82ATFS (29%), 46I (26.8%) and 54V (22.2%). The prevalence of mutations was in line with previous national and international reports, except to nonnucleoside analogue reverse transcriptase inhibitors related mutations, which were more prevalent in this study. Previous exposure to antiretroviral drugs was associated with genotypic resistance to specific drugs, leading to treatment failure in HIV patients. |
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HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, BrazilHIV-1genotypeantiretroviralsdrug-experienced patientsAntiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated the genotypic profile of HIV-1 isolates from treated (drug-experienced) patients in Paraná, Brazil. The prevalence of mutations in reverse transcriptase (RT) and protease (PR) genes were assessed. We analyzed 467 genotypes of patients with HIV-1 viral loads above 1,000 copies/mL. Mutations at HIV-1 RT and PR genes and previously used ART regimens were recorded. The most prevalent RT mutations were: 184V (68.31%), 215YF (51.6%), 103NS (46%), 41L (39.4%), 67N (38.54%), 210W (23.5%), 190ASE (23.2%), and 181C (17.4%). PR mutations were 90M (33.33%), 82ATFS (29%), 46I (26.8%) and 54V (22.2%). The prevalence of mutations was in line with previous national and international reports, except to nonnucleoside analogue reverse transcriptase inhibitors related mutations, which were more prevalent in this study. Previous exposure to antiretroviral drugs was associated with genotypic resistance to specific drugs, leading to treatment failure in HIV patients.Brazilian Society of Infectious Diseases2010-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400009Brazilian Journal of Infectious Diseases v.14 n.4 2010reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702010000400009info:eu-repo/semantics/openAccessToledo,Paula Virginia MichelonCarvalho,Denise Siqueira deRomagnoli,LuizaMarcinko,GustavoCunha,Clovis Arns daSouza,Margely Nunes deBrindeiro,RodrigoQueiroz-Telles,Flávio deeng2010-10-06T00:00:00Zoai:scielo:S1413-86702010000400009Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2010-10-06T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil |
title |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil |
spellingShingle |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil Toledo,Paula Virginia Michelon HIV-1 genotype antiretrovirals drug-experienced patients |
title_short |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil |
title_full |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil |
title_fullStr |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil |
title_full_unstemmed |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil |
title_sort |
HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil |
author |
Toledo,Paula Virginia Michelon |
author_facet |
Toledo,Paula Virginia Michelon Carvalho,Denise Siqueira de Romagnoli,Luiza Marcinko,Gustavo Cunha,Clovis Arns da Souza,Margely Nunes de Brindeiro,Rodrigo Queiroz-Telles,Flávio de |
author_role |
author |
author2 |
Carvalho,Denise Siqueira de Romagnoli,Luiza Marcinko,Gustavo Cunha,Clovis Arns da Souza,Margely Nunes de Brindeiro,Rodrigo Queiroz-Telles,Flávio de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Toledo,Paula Virginia Michelon Carvalho,Denise Siqueira de Romagnoli,Luiza Marcinko,Gustavo Cunha,Clovis Arns da Souza,Margely Nunes de Brindeiro,Rodrigo Queiroz-Telles,Flávio de |
dc.subject.por.fl_str_mv |
HIV-1 genotype antiretrovirals drug-experienced patients |
topic |
HIV-1 genotype antiretrovirals drug-experienced patients |
description |
Antiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated the genotypic profile of HIV-1 isolates from treated (drug-experienced) patients in Paraná, Brazil. The prevalence of mutations in reverse transcriptase (RT) and protease (PR) genes were assessed. We analyzed 467 genotypes of patients with HIV-1 viral loads above 1,000 copies/mL. Mutations at HIV-1 RT and PR genes and previously used ART regimens were recorded. The most prevalent RT mutations were: 184V (68.31%), 215YF (51.6%), 103NS (46%), 41L (39.4%), 67N (38.54%), 210W (23.5%), 190ASE (23.2%), and 181C (17.4%). PR mutations were 90M (33.33%), 82ATFS (29%), 46I (26.8%) and 54V (22.2%). The prevalence of mutations was in line with previous national and international reports, except to nonnucleoside analogue reverse transcriptase inhibitors related mutations, which were more prevalent in this study. Previous exposure to antiretroviral drugs was associated with genotypic resistance to specific drugs, leading to treatment failure in HIV patients. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702010000400009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.14 n.4 2010 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209241465356288 |