Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals

Detalhes bibliográficos
Autor(a) principal: Bezerra, Caroline A.
Data de Publicação: 2011
Outros Autores: Cardoso, Thiago M., Giudice, Angela, Porto, Maria Aurélia da Fonseca, Santos, Silvane Maria Braga, Carvalho Filho, Edgar Marcelino de, Bacellar, Maria Olívia Amado Ramos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5437
Resumo: texto completo: acesso restrito. p.310–317.
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spelling Bezerra, Caroline A.Cardoso, Thiago M.Giudice, AngelaPorto, Maria Aurélia da FonsecaSantos, Silvane Maria BragaCarvalho Filho, Edgar Marcelino deBacellar, Maria Olívia Amado RamosBezerra, Caroline A.Cardoso, Thiago M.Giudice, AngelaPorto, Maria Aurélia da FonsecaSantos, Silvane Maria BragaCarvalho Filho, Edgar Marcelino deBacellar, Maria Olívia Amado Ramos2012-02-24T13:30:04Z20111365-3083http://www.repositorio.ufba.br/ri/handle/ri/5437v. 74.texto completo: acesso restrito. p.310–317.Human T cell lymphotropic virus type-1 (HTLV-1) induces activation and spontaneous proliferation of T cells with production of type-1 pro-inflammatory cytokines. It modifies the immune response to other antigens and increases susceptibility to infectious diseases. However, little is known about innate immunity in HTLV-1 infection. HTLV-1-infected individuals have higher spontaneous neutrophil activation than HTLV-1-seronegative individuals, as shown by the nitroblue tetrazolium (NBT) assay. This study was conducted to evaluate neutrophil function in HTLV-1-infected individuals. Participants in the study included 18 HTLV-1-infected individuals and 14 HTLV-1-seronegative controls. We evaluated the ability of neutrophils (PMNs) to control a parasite infection, to produce peroxynitrite, cytokines and chemokines and to express activation markers in cultures when stimulated with LPS or infected with Leishmania. When compared with the control group, there was no difference in the percentage of PMNs infected with Leishmania or in the number of amastigotes ⁄ 100 PMNs in HTLV-1-infected individuals. The microbicidal activity of the PMNs and the levels of CXCL8 and CCL4 released by these cells did not show a difference between HTLV-1- infected individuals and the control group. In both the HTLV-1 group and the control group, infection with Leishmania or stimulation of PMNs led to cellular activation. These observations suggest that neutrophils from HTLV-1- infected individuals have preserved their ability to become activated and to produce chemokines and peroxynitrite after stimulation and that the susceptibility to infection by intracellular Leishmania amazonensis in HTLV-1-infected individuals does not depend on impairment of neutrophil function.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-02-24T13:30:04Z No. of bitstreams: 1 j.1365-3083.2011.02579.x.pdf: 215181 bytes, checksum: 5e48a710e993b5a87184fd77f107b1ec (MD5)Made available in DSpace on 2012-02-24T13:30:04Z (GMT). No. of bitstreams: 1 j.1365-3083.2011.02579.x.pdf: 215181 bytes, checksum: 5e48a710e993b5a87184fd77f107b1ec (MD5) Previous issue date: 2011doi: 10.1111/j.1365-3083.2011.02579.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEvaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected IndividualsScandinavian Journal of Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALj.1365-3083.2011.02579.x.pdfj.1365-3083.2011.02579.x.pdfapplication/pdf215181https://repositorio.ufba.br/bitstream/ri/5437/1/j.1365-3083.2011.02579.x.pdf5e48a710e993b5a87184fd77f107b1ecMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5437/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTj.1365-3083.2011.02579.x.pdf.txtj.1365-3083.2011.02579.x.pdf.txtExtracted texttext/plain37249https://repositorio.ufba.br/bitstream/ri/5437/3/j.1365-3083.2011.02579.x.pdf.txt169f6f417ce1ce19b2262893f746a0d2MD53ri/54372022-07-05 14:03:13.338oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
dc.title.alternative.pt_BR.fl_str_mv Scandinavian Journal of Immunology
title Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
spellingShingle Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
Bezerra, Caroline A.
title_short Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
title_full Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
title_fullStr Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
title_full_unstemmed Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
title_sort Evaluation of the Microbicidal Activity and Cytokines/Chemokines Profile Released by Neutrophils from HTLV-1-Infected Individuals
author Bezerra, Caroline A.
author_facet Bezerra, Caroline A.
Cardoso, Thiago M.
Giudice, Angela
Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
author_role author
author2 Cardoso, Thiago M.
Giudice, Angela
Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bezerra, Caroline A.
Cardoso, Thiago M.
Giudice, Angela
Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
Bezerra, Caroline A.
Cardoso, Thiago M.
Giudice, Angela
Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Carvalho Filho, Edgar Marcelino de
Bacellar, Maria Olívia Amado Ramos
description texto completo: acesso restrito. p.310–317.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-02-24T13:30:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5437
dc.identifier.issn.none.fl_str_mv 1365-3083
dc.identifier.number.pt_BR.fl_str_mv v. 74.
identifier_str_mv 1365-3083
v. 74.
url http://www.repositorio.ufba.br/ri/handle/ri/5437
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv doi: 10.1111/j.1365-3083.2011.02579.x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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