Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6730 |
Resumo: | p. 1-7 |
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Van Weyenbergh, JohanSantana, GiséliaD'Oliveira Junior, ArgemiroSantos, Anibal F.Costa, Carlos Henrique NeryCarvalho Filho, Edgar Marcelino deBarral, Aldina Maria PradoBarral-Netto, ManoelVan Weyenbergh, JohanSantana, GiséliaD'Oliveira Junior, ArgemiroSantos, Anibal F.Costa, Carlos Henrique NeryCarvalho Filho, Edgar Marcelino deBarral, Aldina Maria PradoBarral-Netto, Manoel2012-09-17T14:59:13Z2012-09-17T14:59:13Z20041471-2334http://www.repositorio.ufba.br/ri/handle/ri/6730v. 4, n. 50p. 1-7The process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite. Blood was collected from 31 patients with either localized cutaneous (LCL), mucosal (ML) or visceral (VL) leishmaniasis, as well as from 25 controls from endemic and non-endemic areas. Anti-Leishmania humoral and cellular immune response were evaluated by quantifying specific plasma IgG, lymphoproliferation and cytokine production, respectively. Plasma levels of Cu and Zn were quantified by atomic absorption spectrophotometry. A significant decrease in plasma Zn was observed in all three patient groups (p < 0.01 for LCL and ML, p < 0.001 for VL), as compared to controls, but only VL (7/10) and ML (1/7) patients displayed overt Zn deficiency. Plasma Cu was increased in LCL and VL (p < 0.001) but not in ML, and was strongly correlated to anti-Leishmania IgG (Spearman r = 0.65, p = 0.0028). Cu/Zn ratios were highest in patients with deficient cellular (VL<<LCL<ML) and exacerbated humoral (VL>LCL>ML) immune response. Ex vivo production of parasite-induced IFN-γ was negatively correlated to plasma Cu levels in LCL (r = -0.57, p = 0.01). In vitro, increased Cu levels inhibited IFN-γ production. 1. Zn deficiency in VL and ML indicate possible therapeutic administration of Zn in these severe forms of leishmaniasis. 2. Plasma Cu positively correlates to humoral immune response across patient groups. 3. Environmentally or genetically determined increases in Cu levels might augment susceptibility to infection with intracellular pathogens, by causing a decrease in IFN-γ production.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-09-17T14:59:13Z No. of bitstreams: 1 (205).pdf: 283895 bytes, checksum: bc9a1606efa0c971b0d550c922b8e5ef (MD5)Made available in DSpace on 2012-09-17T14:59:13Z (GMT). No. of bitstreams: 1 (205).pdf: 283895 bytes, checksum: bc9a1606efa0c971b0d550c922b8e5ef (MD5) Previous issue date: 2004BioMed Centralhttp://dx.doi.org/10.1186/1471-2334-4-50reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAZinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro studyBMC Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL(205).pdf(205).pdfapplication/pdf283895https://repositorio.ufba.br/bitstream/ri/6730/1/%28205%29.pdfbc9a1606efa0c971b0d550c922b8e5efMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6730/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(205).pdf.txt(205).pdf.txtExtracted texttext/plain27427https://repositorio.ufba.br/bitstream/ri/6730/3/%28205%29.pdf.txt29700aaaa66996192377e311746be411MD53ri/67302022-07-05 14:03:46.445oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:46Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study |
| dc.title.alternative.pt_BR.fl_str_mv |
BMC Infectious Diseases |
| title |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study |
| spellingShingle |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study Van Weyenbergh, Johan |
| title_short |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study |
| title_full |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study |
| title_fullStr |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study |
| title_full_unstemmed |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study |
| title_sort |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study |
| author |
Van Weyenbergh, Johan |
| author_facet |
Van Weyenbergh, Johan Santana, Gisélia D'Oliveira Junior, Argemiro Santos, Anibal F. Costa, Carlos Henrique Nery Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Barral-Netto, Manoel |
| author_role |
author |
| author2 |
Santana, Gisélia D'Oliveira Junior, Argemiro Santos, Anibal F. Costa, Carlos Henrique Nery Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Barral-Netto, Manoel |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Van Weyenbergh, Johan Santana, Gisélia D'Oliveira Junior, Argemiro Santos, Anibal F. Costa, Carlos Henrique Nery Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Barral-Netto, Manoel Van Weyenbergh, Johan Santana, Gisélia D'Oliveira Junior, Argemiro Santos, Anibal F. Costa, Carlos Henrique Nery Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Barral-Netto, Manoel |
| description |
p. 1-7 |
| publishDate |
2004 |
| dc.date.issued.fl_str_mv |
2004 |
| dc.date.accessioned.fl_str_mv |
2012-09-17T14:59:13Z |
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2012-09-17T14:59:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://www.repositorio.ufba.br/ri/handle/ri/6730 |
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1471-2334 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 4, n. 50 |
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1471-2334 v. 4, n. 50 |
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http://www.repositorio.ufba.br/ri/handle/ri/6730 |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BioMed Central |
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BioMed Central |
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http://dx.doi.org/10.1186/1471-2334-4-50 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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