The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors

Detalhes bibliográficos
Autor(a) principal: Luz, C. P.
Data de Publicação: 2007
Outros Autores: Souza, A., Reis, R., Mineiro, P., Ferreira, Hilda Silva, Fregoneze, J. B., Silva, E. De Castro e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14551
Resumo: Texto completo: acesso restrito. p. 178-194
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spelling Luz, C. P.Souza, A.Reis, R.Mineiro, P.Ferreira, Hilda SilvaFregoneze, J. B.Silva, E. De Castro eLuz, C. P.Souza, A.Reis, R.Mineiro, P.Ferreira, Hilda SilvaFregoneze, J. B.Silva, E. De Castro e2014-02-06T20:10:30Z20070006-8993http://repositorio.ufba.br/ri/handle/ri/14551v. 1139, n. 1Texto completo: acesso restrito. p. 178-194In the present paper, we have evaluated the participation of 5-HT3 and 5-HT2C receptors in the central amygdala (CeA) in the regulation of water and salt intake in sodium-depleted rats. m-CPBG-induced pharmacological activation of 5-HT3 receptors located in the CeA resulted in a significant reduction in salt intake in sodium-depleted rats. This antinatriorexic effect of m-CPBG was reverted by pretreatment with the selective 5-HT3 receptor antagonist ondansetron. The injection of ondansetron alone into the CeA had no effect on sodium-depleted and normonatremic rats. Conversely, pharmacological stimulation of 5-HT2C receptors located in the central amygdala by the selective 5-HT2C receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats. Additionally, the administration of a selective 5-HT2C receptor blocker, SDZ SER 082, failed to modify salt intake in rats submitted to sodium depletion. These results lead to the conclusion that the pharmacological activation of 5-HT3 receptors located within the CeA inhibits salt intake in sodium-depleted rats and that 5-HT2C receptors located within the CeA appear to be dissociated from the salt intake control mechanisms operating in the central amygdala.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-31T14:42:39Z No. of bitstreams: 1 1-s2.0-S0006899307000340-main.pdf: 2527933 bytes, checksum: 356b6d6080193506f3bf84ede860e3bb (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-02-06T20:10:30Z (GMT) No. of bitstreams: 1 1-s2.0-S0006899307000340-main.pdf: 2527933 bytes, checksum: 356b6d6080193506f3bf84ede860e3bb (MD5)Made available in DSpace on 2014-02-06T20:10:30Z (GMT). No. of bitstreams: 1 1-s2.0-S0006899307000340-main.pdf: 2527933 bytes, checksum: 356b6d6080193506f3bf84ede860e3bb (MD5) Previous issue date: 2007http://dx.doi.org/10.1016/j.brainres.2007.01.012reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASerotonin5HT2 receptor5HT3 receptorSalt intakeWater intakeThirstAmygdalaCentral amygdalaThe central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptorsBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0006899307000340-main.pdf1-s2.0-S0006899307000340-main.pdfapplication/pdf2527933https://repositorio.ufba.br/bitstream/ri/14551/1/1-s2.0-S0006899307000340-main.pdf356b6d6080193506f3bf84ede860e3bbMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14551/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT1-s2.0-S0006899307000340-main.pdf.txt1-s2.0-S0006899307000340-main.pdf.txtExtracted texttext/plain65473https://repositorio.ufba.br/bitstream/ri/14551/3/1-s2.0-S0006899307000340-main.pdf.txt726aaa16bc7dca452f36a20516535ddeMD53ri/145512022-07-05 14:02:48.512oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
dc.title.alternative.pt_BR.fl_str_mv Brain Research
title The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
spellingShingle The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
Luz, C. P.
Serotonin
5HT2 receptor
5HT3 receptor
Salt intake
Water intake
Thirst
Amygdala
Central amygdala
title_short The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
title_full The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
title_fullStr The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
title_full_unstemmed The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
title_sort The central amygdala regulates sodium intake in sodium-depleted rats: role of 5-HT3 and 5-HT2C receptors
author Luz, C. P.
author_facet Luz, C. P.
Souza, A.
Reis, R.
Mineiro, P.
Ferreira, Hilda Silva
Fregoneze, J. B.
Silva, E. De Castro e
author_role author
author2 Souza, A.
Reis, R.
Mineiro, P.
Ferreira, Hilda Silva
Fregoneze, J. B.
Silva, E. De Castro e
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luz, C. P.
Souza, A.
Reis, R.
Mineiro, P.
Ferreira, Hilda Silva
Fregoneze, J. B.
Silva, E. De Castro e
Luz, C. P.
Souza, A.
Reis, R.
Mineiro, P.
Ferreira, Hilda Silva
Fregoneze, J. B.
Silva, E. De Castro e
dc.subject.por.fl_str_mv Serotonin
5HT2 receptor
5HT3 receptor
Salt intake
Water intake
Thirst
Amygdala
Central amygdala
topic Serotonin
5HT2 receptor
5HT3 receptor
Salt intake
Water intake
Thirst
Amygdala
Central amygdala
description Texto completo: acesso restrito. p. 178-194
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-02-06T20:10:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14551
dc.identifier.issn.none.fl_str_mv 0006-8993
dc.identifier.number.pt_BR.fl_str_mv v. 1139, n. 1
identifier_str_mv 0006-8993
v. 1139, n. 1
url http://repositorio.ufba.br/ri/handle/ri/14551
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.brainres.2007.01.012
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
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instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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