Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats

Detalhes bibliográficos
Autor(a) principal: Souza, Anderson
Data de Publicação: 2006
Outros Autores: Reis, Rodolfo, Fregoneze, Josmara Bartolomei, Castro e Silva, Emilio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13660
Resumo: Texto completo: acesso restrito. p.121–132
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spelling Souza, AndersonReis, RodolfoFregoneze, Josmara BartolomeiCastro e Silva, Emilio deSouza, AndersonReis, RodolfoFregoneze, Josmara BartolomeiCastro e Silva, Emilio de2013-11-16T12:36:53Z20060006-8993http://repositorio.ufba.br/ri/handle/ri/13660v.1099, n. 1Texto completo: acesso restrito. p.121–132In the present study, we investigated the role of 5-HT3 and 5-HT2C receptors located within the medial amygdala (MeA) in the control of water and salt intake in sodium-depleted rats. Pharmacological activation of 5-HT3 receptors located in the medial amygdala by the selective 5-HT3 receptor agonist m-CPBG significantly reduced salt intake in sodium-depleted rats, an effect that is reverted by pretreatment with the selective 5-HT3 receptor antagonist ondansetron. In addition, the injection of ondansetron alone into the medial amygdala had no effect on salt intake in sodium-depleted and in sodium-repleted rats. Pharmacological stimulation of 5-HT2C receptors located in the medial amygdala by the selective 5-HT2C receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats, whereas the blockade of these receptors by the selective 5-HT2C receptor antagonist SDZ SER 082 significantly reduced salt intake in this same group of animals. These results lead to the conclusion that the pharmacological activation of 5-HT3 receptors located within the MeA inhibits salt intake in sodium-depleted rats and that, in this same brain region, the functional integrity of 5-HT2C receptors is required to achieve the full expression of sodium appetite in sodium-depleted rats.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-05T15:56:02Z No. of bitstreams: 1 1-s2.0-S0006899306012169-main.pdf: 354476 bytes, checksum: 165c28b07a58e28408009cbe13960397 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-16T12:36:53Z (GMT) No. of bitstreams: 1 1-s2.0-S0006899306012169-main.pdf: 354476 bytes, checksum: 165c28b07a58e28408009cbe13960397 (MD5)Made available in DSpace on 2013-11-16T12:36:53Z (GMT). No. of bitstreams: 1 1-s2.0-S0006899306012169-main.pdf: 354476 bytes, checksum: 165c28b07a58e28408009cbe13960397 (MD5) Previous issue date: 2006http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.brainres.2006.04.083reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAm-CPPSerotonin5-HT2C receptorm-CPBG5-HT3 receptorSalt intakeRole of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted ratsBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0006899306012169-main.pdf1-s2.0-S0006899306012169-main.pdfapplication/pdf354476https://repositorio.ufba.br/bitstream/ri/13660/1/1-s2.0-S0006899306012169-main.pdf165c28b07a58e28408009cbe13960397MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13660/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0006899306012169-main.pdf.txt1-s2.0-S0006899306012169-main.pdf.txtExtracted texttext/plain58263https://repositorio.ufba.br/bitstream/ri/13660/3/1-s2.0-S0006899306012169-main.pdf.txtc18fcd61001d3cab33f0eded89ffa32eMD53ri/136602022-07-05 14:02:50.308oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:50Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
dc.title.alternative.pt_BR.fl_str_mv Brain Research
title Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
spellingShingle Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
Souza, Anderson
m-CPP
Serotonin
5-HT2C receptor
m-CPBG
5-HT3 receptor
Salt intake
title_short Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
title_full Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
title_fullStr Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
title_full_unstemmed Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
title_sort Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats
author Souza, Anderson
author_facet Souza, Anderson
Reis, Rodolfo
Fregoneze, Josmara Bartolomei
Castro e Silva, Emilio de
author_role author
author2 Reis, Rodolfo
Fregoneze, Josmara Bartolomei
Castro e Silva, Emilio de
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza, Anderson
Reis, Rodolfo
Fregoneze, Josmara Bartolomei
Castro e Silva, Emilio de
Souza, Anderson
Reis, Rodolfo
Fregoneze, Josmara Bartolomei
Castro e Silva, Emilio de
dc.subject.por.fl_str_mv m-CPP
Serotonin
5-HT2C receptor
m-CPBG
5-HT3 receptor
Salt intake
topic m-CPP
Serotonin
5-HT2C receptor
m-CPBG
5-HT3 receptor
Salt intake
description Texto completo: acesso restrito. p.121–132
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-11-16T12:36:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13660
dc.identifier.issn.none.fl_str_mv 0006-8993
dc.identifier.number.pt_BR.fl_str_mv v.1099, n. 1
identifier_str_mv 0006-8993
v.1099, n. 1
url http://repositorio.ufba.br/ri/handle/ri/13660
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.brainres.2006.04.083
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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