Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats

Detalhes bibliográficos
Autor(a) principal: Magrani, Janeide
Data de Publicação: 2004
Outros Autores: Silva, Emilio de Castro e, Varjão, Bruno, Duarte, Gleison Vieira, Ramos, Ana Claudia, Athanazio, Rodrigo Abensur, Barbetta, Marcelo Campos, Luz, Patricia, Fregoneze, Josmara Bartolomei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7155
Resumo: p. 189-198
id UFBA-2_6377bb2211dfaf4257b752ccdeeeb8f6
oai_identifier_str oai:repositorio.ufba.br:ri/7155
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Magrani, JaneideSilva, Emilio de Castro eVarjão, BrunoDuarte, Gleison VieiraRamos, Ana ClaudiaAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposLuz, PatriciaFregoneze, Josmara BartolomeiMagrani, JaneideSilva, Emilio de Castro eVarjão, BrunoDuarte, Gleison VieiraRamos, Ana ClaudiaAthanazio, Rodrigo AbensurBarbetta, Marcelo CamposLuz, PatriciaFregoneze, Josmara Bartolomei2012-11-08T19:32:37Z20040091-3057http://www.repositorio.ufba.br/ri/handle/ri/7155v. 79, n. 1p. 189-198The aim of the present study was to investigate the effect of the pharmacological blockade of histamine H1 and H2 receptors located within the ventromedial hypothalamus (VMH) on overnight food and water intake and on water intake elicited by two physiological stimuli: hyperosmolarity induced by an acute intragastric salt load and water deprivation. During the overnight period, the pharmacological blockade of both H1 and H2 VMH receptors significantly increased food intake and decreased water intake. In hyperosmotic rats, the blockade of H1 VMH receptors reduced water intake, while the blockade of H2 receptors in this same region yielded no significant effect. Additionally, in water-deprived rats, the blockade of both H1 and H2 receptors located within the VMH induced a significant decrease in water intake. The inhibitory effects on drinking behavior observed in this study do not seem to be a consequence of any billness-inducingQ effect provoked by the central administration of the antihistaminergic agents employed here, because an aversion test indicated that the injection of those compounds into the VMH does not induce any billness-likeQ effect. In addition, the central administration of either mepyramine or cimetidine to dehydrated and hyperosmotic rats did not produce any reduction in locomotor activity measured in an openfield arena. Injections of the antihistaminergic agents used here into the regions that circumscribe the VMH produced no significant effects on water or food intake, indicating that the actions observed here may be specifically attributed to the set of histaminergic receptors situated within the VMH.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-11-08T19:32:36Z No. of bitstreams: 1 1-s2.0-S0091305704002461-main.pdf: 576313 bytes, checksum: af4078d7cac9e336a17bd195c14b8f89 (MD5)Made available in DSpace on 2012-11-08T19:32:37Z (GMT). No. of bitstreams: 1 1-s2.0-S0091305704002461-main.pdf: 576313 bytes, checksum: af4078d7cac9e336a17bd195c14b8f89 (MD5) Previous issue date: 2004Elsevierhttp://dx.doi.org/10.1016/j.pbb.2004.07.004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAWater intakeFood intakeVentromedial hypothalamusThirstCimetidineMepyramineH1 receptorH2 receptorHistaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in ratsPharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/7155/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52ORIGINAL1-s2.0-S0091305704002461-main.pdf1-s2.0-S0091305704002461-main.pdfapplication/pdf576313https://repositorio.ufba.br/bitstream/ri/7155/1/1-s2.0-S0091305704002461-main.pdfaf4078d7cac9e336a17bd195c14b8f89MD51TEXT1-s2.0-S0091305704002461-main.pdf.txt1-s2.0-S0091305704002461-main.pdf.txtExtracted texttext/plain43919https://repositorio.ufba.br/bitstream/ri/7155/3/1-s2.0-S0091305704002461-main.pdf.txt728dbad327c241cdffcf6b110e6bd464MD53ri/71552022-07-05 14:03:30.753oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
dc.title.alternative.pt_BR.fl_str_mv Pharmacology Biochemistry and Behavior
title Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
spellingShingle Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
Magrani, Janeide
Water intake
Food intake
Ventromedial hypothalamus
Thirst
Cimetidine
Mepyramine
H1 receptor
H2 receptor
title_short Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
title_full Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
title_fullStr Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
title_full_unstemmed Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
title_sort Histaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in rats
author Magrani, Janeide
author_facet Magrani, Janeide
Silva, Emilio de Castro e
Varjão, Bruno
Duarte, Gleison Vieira
Ramos, Ana Claudia
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Luz, Patricia
Fregoneze, Josmara Bartolomei
author_role author
author2 Silva, Emilio de Castro e
Varjão, Bruno
Duarte, Gleison Vieira
Ramos, Ana Claudia
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Luz, Patricia
Fregoneze, Josmara Bartolomei
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Magrani, Janeide
Silva, Emilio de Castro e
Varjão, Bruno
Duarte, Gleison Vieira
Ramos, Ana Claudia
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Luz, Patricia
Fregoneze, Josmara Bartolomei
Magrani, Janeide
Silva, Emilio de Castro e
Varjão, Bruno
Duarte, Gleison Vieira
Ramos, Ana Claudia
Athanazio, Rodrigo Abensur
Barbetta, Marcelo Campos
Luz, Patricia
Fregoneze, Josmara Bartolomei
dc.subject.por.fl_str_mv Water intake
Food intake
Ventromedial hypothalamus
Thirst
Cimetidine
Mepyramine
H1 receptor
H2 receptor
topic Water intake
Food intake
Ventromedial hypothalamus
Thirst
Cimetidine
Mepyramine
H1 receptor
H2 receptor
description p. 189-198
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-11-08T19:32:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7155
dc.identifier.issn.none.fl_str_mv 0091-3057
dc.identifier.number.pt_BR.fl_str_mv v. 79, n. 1
identifier_str_mv 0091-3057
v. 79, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7155
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.pbb.2004.07.004
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/7155/2/license.txt
https://repositorio.ufba.br/bitstream/ri/7155/1/1-s2.0-S0091305704002461-main.pdf
https://repositorio.ufba.br/bitstream/ri/7155/3/1-s2.0-S0091305704002461-main.pdf.txt
bitstream.checksum.fl_str_mv 8bb3e3eb871f5854a9ec419f68651b60
af4078d7cac9e336a17bd195c14b8f89
728dbad327c241cdffcf6b110e6bd464
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459410075287552

Registros relacionados